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| 1 | Liver expression of steroid hormones and Apolipoprotein D receptors in hepatocellular carcinoma显示文摘AIM: To evaluate the tissular expression of Androgen (A), Estrogen (E) and Progesterone (Pg) receptors, and Apolipoprotein D (ApoD), in liver tumors from resected hepatocellular carcinoma (HCC) cases in order to assess their possible relationship to prognosis. METHODS: We performed an immunohistochemical study using tissue microarrays (containing more than 260 cancer specimens, from 31 HCC patients and controls) to determine the presence of specif ic antibodies against AR, ER, PgR and ApoD, correlating their findings with several clinico-pathological and biological variables. The staining results were categorized using a semi-quantitive score based on their intensity, and the percentage of immunostained cells was measured. RESULTS: A total of 21 liver tumors (67.7%) were positive for AR; 16 (51.6%) for ER; 26 (83.9%) for PgR and 12 (38.7%) stained for ApoD. We have found a wide variability in the immunostaining score values for each protein, with a median (range) of 11.5 (11.5-229.5) for AR; 11.1 (8.5-65) for ER; 14.2 (4-61) for PgR; and 37.7 (13.8-81.1) for ApoD. A history of heavy ethanol consumption, correlated positively with AR and PgR and negatively with ER status. HCV chronic infection also correlated positively with AR and PgR status. However, the presence of ApoD immunostaining did not correlate with any of these variables. Tumors with a positive immuno-staining for PgR showed a better prognosis. CONCLUSION: Our results indicate a moderate clinical value of the steroid receptor status in HCC, emphasizing the need to perform further studies in order to evaluate the possible role of new hormonal-based therapies. | FJ Vizoso M Rodriguez A Altadill ML González-Diéguez A Linares LO González S Junquera F Fresno-Forcelledo MD Corte L Rodrigo | 2007 | World Journal of Gastroenterology2007，13，23： | 11 |
| 2 | Adaptive randomized study of idarubicin and cytarabine versus troxacitabine and cytarabine versus troxaeitabine and idarubicin in untreated patient 50 years or older with adverse karyotype acute myeloid leukemia 显示文摘 | Giles F J Kantar JHM Cortes JE | 2003 | J Clin Oncol2003，21，9： | 1 |
| 3 | Suitability of SRM and CN glasses as neutron fluence monitors in FT dating显示文摘 | Bellemans F De Corte F Van den Haute P | 1993 | Nuclear Tracks and Radiation Measurements1993，21，4： | 1 |
| 4 | Coordination and geometric optimi- zation via distributed dynamical systems 显示文摘 | CORTES J BULLO F | 2006 | The SIAM Journal on Control and Optimization2006，44，5： | 1 |
| 5 | The whole relationship between environmental variables and finn performance: competitive advantage and firm resources as mediator variables 显示文摘 | LOPEZ- GAMERO M D MOLINA -AZORIN J F CLAVER- CORTeS E | 2009 | Journal of environmental management2009，90，10： | 1 |
| 6 | Shallow tunnels in cohesionless soil:Stability of tunnel face显示文摘 | CHAMBON P CORTE J F | 1994 | Journal of Geotechnical Engineering1994，120，7： | 1 |
| 7 | Support effects on the performance of Pt/CeO2 and Pt/ Al2O3 catalysts for the dry reforming of methane 显示文摘 | Gonzalez F Gomez- Cortes A Arenas -Alatorre F | 1998 | Appl Catal A1998，3，： | 1 |
| 8 | Provocative hypothalamopituitary axis tests in severe head injury:correlations with severity and prognosis显示文摘 | Della Corte F Mancini A Valle D | 1998 | Crit Care Med1998，26，8： | 1 |
| 9 | Environmental practices and firm performance: an empirical analysis in the Spanish hotel industry 显示文摘 | MOLINA - AZORIN J F CLAVER - CORTeS E PEREIRA - MO- LINER J | 2009 | Journal of Cleaner Production2009，17，5： | 1 |
| 10 | Involvement of oxidative stress in the pre-malignant and malignant states of cervical cancer in women 显示文摘 | Goncalves TL Erthal F Corte CL | 2005 | Clin Biochem2005，38，12： | 1 |
| 11 | Motion Coordination with Distribu- ted Information显示文摘 | Martinez S Cortes J Bullo F | 2007 | IEEE Control Systems2007，27，4： | 1 |
| 12 | Com-parison of idarubicin+ara-C,fludarabine+ara-C,andtopotecan+ara-C-based regimens in treatment ofnewly diagnosed acute myeloid leukemia,refractory a-nemia with excess blasts in transformation,or refrac-tory anemia with excess blasts显示文摘 | ESTEY E H THALL P F CORTES J E | 2001 | Blood2001，98，： | 1 |
| 13 | An unusually large multifunctional polypeptide in the erythromycin- producing polyketide synthase of Saecharopolyspora erythraea显示文摘 | Cortes J Haydock S F Roberts G A | 1990 | Nature1990，348，： | 1 |
| 14 | Analysis of embedded CORBA middleware performance on urban dis- tributed transportation equipments 显示文摘 | TORAL S L BARRERO F CORTES F | 2013 | Computer Stand- ards & Interfaces2013，35，1： | 1 |
| 15 | Easing the inferential Leap in competency modeling:The effects of task-related information and subject matter expertise 显示文摘 | Lieveus F Sanchez JI Corte WD | 2004 | Personel Psychol2004，57，4： | 1 |
| 16 | Reproductive cycle of Manila clam Ruditapes philippinarum (Adams and Reeve 1850) ,in Ria of Vigo ( NW Spain ) 显示文摘 | Rodriguez M E Pazo J P Cortes F F | 1992 | Scientian Marina1992，56，1： | 1 |
| 17 | Artificial muscle:Movement and position control显示文摘 | Otero T F Cortes M T | 2004 | Chem Commun2004，，3： | 1 |
| 18 | Wheat flour fortification with folic acid:changes in neural tube defects rates in Chile 显示文摘 | Cortes F Mellado C Pardo RA | 2012 | Am J Med Genet A2012，158，8： | 1 |
| 19 | Result of high-dose imatinib mesylate in patients with Philadelphia chromosomepositive chronic myeloid leukemia after failure of interferon-α显示文摘 | Cortes J Giles F O'Brien S | 2003 | Blood2003，102，： | 1 |
| 20 | The accuracy and precision of the experimental adetermination in the 1/E^1+α epithermal neutron spectrum显示文摘 | de CORTE F SORDO K MOENS L | 1981 | J Radioanal Chem1981，62，12： | 1 |
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