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| 1 | 螺内酯与可乐定作为难治性高血压第4种治疗药物的比较:难治性高血压的最佳治疗随机研究显示文摘该研究旨在通过一个多中心随机试验对作为难治性高血压患者的第4种治疗药物的螺内酯与可乐定进行比较。采用药丸计数评估药物治疗依从性。难治性高血压患者(定义为包括1种利尿剂在内的3种药物治疗12周,诊室及动态血压监测血压仍未控制)随机给予螺内酯(12.5~50 mg/d)或可乐定(0.1~0.3mg,2次/d)继续治疗12周。 | Krieger EM Drager LF Giorgi DMA Pereira AC Barreto-Filho JAS Nogueira AR Mill JG Lotufo PA Amodeo C Batista MC Bodanese LC Carvalho ACC Castro I Chaves H Costa EAS Feitosa GS Franco RJS Fuchs FD Guimarāes AC Jardim PC Machado CA Magalhāes ME Mion D Jr Nascimento RM Nobre F Nóbrega AC Ribeiro ALP Rodrigues-Sobrinho CR Sanjuliani AF Teixeira MDCB Krieger JE ReHOT Investigators 赵狄 练桂丽 | 2018 | 中华高血压杂志2018，26，3： | 7 |
| 2 | Genomic prediction of fruit texture and training population optimization towards the application of genomic selection in apple显示文摘Texture is a complex trait and a major component of fruit quality in apple.While the major effect of MdPG1,a gene controlling firmness,has already been exploited in elite cultivars,the genetic basis of crispness remains poorly understood.To further improve fruit texture,harnessing loci with minor effects via genomic selection is therefore necessary.In this study,we measured acoustic and mechanical features in 537 genotypes to dissect the firmness and crispness components of fruit texture.Predictions of across-year phenotypic values for these components were calculated using a model calibrated with 8,294 SNP markers.The best prediction accuracies following cross-validations within the training set of 259 genotypes were obtained for the acoustic linear distance(0.64).Predictions for biparental families using the entire training set varied from low to high accuracy,depending on the family considered.While adding siblings or half-siblings into the training set did not clearly improve predictions,we performed an optimization of the training set size and composition for each validation set.This allowed us to increase prediction accuracies by 0.17 on average,with a maximal accuracy of 0.81 when predicting firmness in the‘Gala’בPink Lady’family.Our results therefore identified key genetic parameters to consider when deploying genomic selection for texture in apple.In particular,we advise to rely on a large training population,with high phenotypic variability from which a‘tailored training population’can be extracted using a priori information on genetic relatedness,in order to predict a specific target population. | Morgane Roth Hélène Muranty Mario Di Guardo Walter Guerra Andrea Patocchi Fabrizio Costa | 2020 | Horticulture Research2020，7，1： | 4 |
| 3 | NEW TOXOPLASMA GONDII GENOTYPES ISOLATED FROM FREE-RANGE CHICKENS FROM THE FERNANDO DE NORONHA, BRAZIL: UNEXPECTED FINDINGS显示文摘 | Dubey J P Rajendran C Costa D G C Ferreira L R Kwok O C H Qu D Su C Marvulo M F V Alves L C Mota R A Silva J C R | 2010 | The Journal of Parasitology2010，，4： | 2 |
| 4 | The corpus cavernosum after treatment with dutasteride or finasteride: a histomorphometric study in a benign prostatic hyperplasia rodent model显示文摘 | Marcello H A Da Silva Waldemar S Costa Francisco J B Sampaio Diogo B De Souza | 2018 | Asian Journal of Andrology2018，20，5： | 2 |
| 5 | Induction of cold hardiness by salt stress involves synthesis of cold and abscisic acid responsive proteins in Pmato显示文摘 | Ryu S tS Costa A Xin Z G Li P H | 1995 | Plant Cell Physiol1995，36，： | 1 |
| 6 | Cultual practices for managing Bemisia tabaci and associated viral diseases显示文摘 | LUKO HIJI HEATHER S COSTA H S | 2001 | Crop Protection2001，20，： | 1 |
| 7 | Writing on Dirty Paper显示文摘 | Costa M H M | 1983 | IEEE Transactions on Information Theory1983，29，3： | 1 |
| 8 | Oscillatory perturlations of linear problems at resonance显示文摘 | Costa D Jeggle H Schaaf R | 1988 | Results in Mathematics1988，14，： | 1 |
| 9 | Ratio between positive lymph no- and total dissected axillaries lymph nodes as an independent prognostic factor for disease free survival in patients with breast caneer显示文摘 | Megale Costa L J Soares H P Gaspar H A | 2004 | Am J Clin Oncol2004，27，3： | 1 |
| 10 | BNP plasma levels or left atrial di- mension for the prediction of paroxysmal atrial fibrillation in subjects with essential hypertension? 显示文摘 | Amalia H Costas T Marina T | 2013 | Am J Hypertents2013，17，52： | 1 |
| 11 | Hydrodynamic lubrication of textured steel surfaces under reciprocating sliding conditions 显示文摘 | Costa H L Hutchings I M | 2007 | Tribolo- gy International2007，，： | 1 |
| 12 | Deactivation of FCC catalysts显示文摘 | Cerqueira H S Caeiro G Costa L | 2008 | Journal of Molecular Catalysis A: Chemical2008，292，12： | 1 |
| 13 | Deactivation of FCC catalysts显示文摘 | CERQUEIRAA H S CAEIRO G COSTA L | 2008 | J Mol Catal A2008，292，12： | 1 |
| 14 | Trends in the analytical methods for the determinationof trans fatty acids content in foods显示文摘 | ALBUQUERQUE T G COSTA H S CASTILHO M C | 2011 | Trends in Food Scienceand Technology2011，22，11： | 1 |
| 15 | Human papillomavirus infections with multiple types and risk of cervical neoplasia显示文摘 | Trottier H Mahmud S Costa MC | 2006 | Cancer Epidemiol Biomarkers Prev2006，15，7： | 1 |
| 16 | Combined coronary artery bypass grafting and excision of adrenal pheochromocytoma显示文摘 | Seah PW Costa R Wolfenden H | 1995 | J Thorac Cardiovasc Surg1995，110，2： | 1 |
| 17 | Transcription and temporal cascade in Chilo iridescent virus infected cells 显示文摘 | D'Costa S M Yao H Bilimoria S L | 2001 | Arch Viro2001，146，11： | 1 |
| 18 | Xylitol production from eucalyptus wood hydrolysates extracted with organic solvents显示文摘 | Costa Queiroz R H Melchior E de Souza A M | 1997 | Process Biochemistry1997，32，7： | 1 |
| 19 | Nitrogen incorporation into titanium diboride films deposited by dc magnetron sputtering: Structural modifications 显示文摘 | SANCHEZ C M T FONSECA-FILHO H D MAIA DA COSTA M E H | 2009 | Thin Solid Films2009，517，19： | 1 |
| 20 | Transcription and temporal cascade in Chilo iridescent virus infected ceils 显示文摘 | D'COSTA S M YAO H BILIMORIA S L | 2001 | Archives of Virology2001，146，11： | 1 |
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