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| 1 | Concurrent use of aromatase inhibitors and hypofractionated radiation therapy显示文摘AIM: To retrospectively assess the acute and long-term toxicity using aromatase inhibitors (AI) therapy concurrently with hypofractionated radiotherapy (HFRT) in breast cancer patients. METHODS: From November 1999 to October 2007, 66 patients were treated with breast HFRT and concurrent AI. In 63 patients (95.5%), HFRT delivered a total dose of 32.5 Gy to the whole breast within 5 wk (five fractions, one fraction per week). Other fractionations were chosen in three patients for the patients' personal convenience. A subsequent boost to the tumor bed was delivered in 35 patients (53.0%). Acute toxicities were scored according to the Common Toxicity Criteria for Adverse Events v3. Late toxicity was defined as any toxicity occurring more than 6 mo after completion of HFRT and was scored according to the Late Effects Normal Tissue Task Force-Subjective, Objective, Management and Analytic scale. RESULTS: At the end of the HFRT course, 19 patients (28.8%) had no irradiation-related toxicity. Acute grade 1-2 epithelitis was observed in 46 patients (69.7%). One grade 3 toxicity (1.5%) was observed. With a median follow-up of 34 mo (range: 12-94 mo), 31 patients (47%) had no toxicity, and 35 patients (53%) presented with grade 1-2 fibrosis. No grade 3 or greater delayed toxicity was observed. CONCLUSION: We found that AI was well tolerated when given concurrently with HFRT. All toxicities were mild to moderate, and no treatment disruption was necessary. Further prospective assessment is warranted. | Cyrus Chargari Pablo Castro-Pena Ivan Toledano Marc A Bollet Alexia Savignoni Paul Cottu Fatima Laki Franois Campana Patricia De Cremoux Alain Fourquet Youlia M Kirova | 2012 | World Journal of Radiology2012，4，7： | 2 |
| 2 | Platinum based chem otherapy in metastatic triple negative breast cancer: the Insti- rut Curie experience显示文摘 | Staudacher L Cottu PH Dieras V | 2011 | Ann Oncol2011，22，4： | 1 |
| 3 | Circulating tumor cell thresholds and survival scores in advanced metastatic breast cancer: The observational step of the CirCeO1 phase 111 trim 显示文摘 | Helissey C Berger F Cottu P | 2015 | Cancer Lett2015，360，2： | 1 |
| 4 | Effects of cure cycle pressure and voids on some mechanical properties of carbon/ epoxy laminates 显示文摘 | OLIVIER P COTTU J P FERRET B | 1995 | Composites1995，26，7： | 1 |
| 5 | Gemcit- abine-oxaliplatin combination in heavily pretreated metastatic breast cancer:a pilot study on 43 patients显示文摘 | Caruba T Cottu PH Madelaine-Chambrin I | 2007 | Breast J2007，13，2： | 1 |
| 6 | Platinum-based chem- otherapy in metastatic triple-negative breast cancer: the institut curie experience 显示文摘 | Staudacher L Cottu PH Dieras V | 2011 | Ann Oncol2011，22，： | 1 |
| 7 | Gemcitabine-oxaliplatin combination in heavily pretreated metastatic breast cancer: a pilot study on 43 patients显示文摘 | Caruba T Cottu PH Madelaine-Chambrin I | 2007 | Breast J2007，13，2： | 1 |
| 8 | Sentinel node biopsy in early breast cancer: lessons learned from more than 1000 cases at a single institution 显示文摘 | FANCELLU A COTTU P FEO C F | 2012 | Tmnori2012，98，4： | 1 |
| 9 | BAT-26, an iudicator of the replication error phenotype in colorectal cancers and cell lines显示文摘 | Cottu PH Thuille B | 1997 | Cancer Res1997，57，2： | 1 |
| 10 | BAT-26 an indicator of the replication error phonotype in colorcetal cancer and cell lines显示文摘 | Cottu pH Thuille B | 1997 | Cancer Res1997，57，2： | 1 |
| 11 | Gemcit2abine2oxaliplatin combination in heavily pretreated metastatic breast cancer: a pilot study on 43 patients 显示文摘 | Caruba T Cottu PH Madelaine-Chambrin I | 2007 | Breast J2007，13，2： | 1 |
| 12 | Effects of Cure Cycle Pressure and Voids on Some Mechanical Properties of Carbon/Epoxy Laminates 显示文摘 | Olivier P Cottu J P Ferret B | 1995 | Composites1995，26，7： | 1 |
| 13 | Platinum-based chemotherapy in metastatic triple-negative breast cancer: the Institut Curie experience显示文摘 | Staudacher L Cottu PH Dieras V | 2011 | Ann Oncol2011，22，4： | 1 |
| 14 | Platinum - based chemotherapy in metastatic triple - negative breast cancer: the Institut Curie experience 显示文摘 | Standacher L Cottu PH Dieras V | 2011 | Ann Oncol2011，22，4： | 1 |
| 15 | Platinum-based ch-emotherapy in metastatic triple-negative breast cancer:the Institut Curie experience显示文摘 | Staudacher L Cottu PH Dieras V | 2011 | Ann Oncol2011，22，4： | 1 |
| 16 | Platinum-based chemotherapy inmetastatic triple-negative breast cancer: the Institut Curie experience 显示文摘 | Staudacher L Cottu PH Dieras V | 2010 | Ann Oncol2010，22，4： | 1 |
| 17 | Effects of cure cycle pressure and voids on some mechanical properties of carbon/epoxy laminates 显示文摘 | Olivier P Cottu J P Ferret B | 1995 | Composites1995，26，7： | 1 |
| 18 | Gemcitabine-oxaliplatin combination in heavily pretreated metastatic breast cancer: a pilot study on 43 patients 显示文摘 | CARUBA T COTTU P H MADELAINE-CHAMBRIN I | 2007 | Breast J2007，13，2： | 1 |
| 19 | BAT-26, an indicator of the replication error phenotype in colorectal cancers and cell lines 显示文摘 | Hoang JM Cottu PH Thuille B | 1997 | Cancer Res1997，57，2： | 1 |
| 20 | Platinum-based chemotherapy in metastatic triple-negative breast cancer:the Institut Curie experience显示文摘 | Staudacher L Cottu PH Diéras V | 2011 | Ann Oncol2011，22，4： | 1 |
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