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| 1 | Haplotype of prostaglandin synthase 2/cyclooxygenase 2 is involved in the susceptibility to inflammatory bowel disease显示文摘AIM: Prostaglandin G/H synthase 2 (PTGS2 or COX2) is one of the key factors in the cellular response to inflammation.PTGS2 is expressed in the affected intestinal segments of patients with inflammatory bowel diseases (IBD). In IBD patients, non-steroidal anti-inflammatory drugs, which have been shown to reduce both the production and activity of PTGS2, may activate IBD and aggravate the symptoms.We aimed at examining genetic variants of PTGS2 that may be risk factors for IBD.METHODS: We genotyped 291 individuals diagnosed with IBD and 367 controls from the Dutch population for the five most frequent polymorphisms of the PTGS2 gene.Clinical data were collected on all patients. DNA was extracted via normal laboratory methods. Genotyping was carried out using multiplex PCR followed by the Invader Assay and the 5' exonuclease assay (TaqMan). New polymorphism screening was performed by pre-screening with denaturing high-performance liquid chromatography,followed by fluorescent sequencing.RESULTS: Allele 5209G was weakly associated with Crohn's disease (odds ratio [OR] 1.63, 95% confidence interval [CI] 1.03-2.57), and allele 8473T with ulcerative colitis (OR 1.50, 95%CI 1.00-2.27). The haplotype including both alleles showed a strong association with IBD (OR 13.15, 95%CI 3.17-116.15). This haplotype, while rare (-0.3%) in the general population, is found more frequently in patients (3.5%).CONCLUSION: Our data suggest that this haplotype of PTGS2 contributes to the susceptibility of IBD. | David G Cox J Bart A Crusius Petra HM Peeters H Bas Bueno-de-Mesquita A Salvador Pe(n|~)a Federico Canzian | 2005 | World Journal of Gastroenterology2005，11，38： | 10 |
| 2 | 具有低动脉粥样硬化风险特征的专业耐力运动员的亚临床冠状动脉疾病发病率显示文摘研究表明,具有冠状动脉疾病(coronary artery disease,CAD)危险因素的中老年(健将)运动员比久坐个体冠状动脉钙化(coronary artery calcium,CAC)评分更高。尚没有研究评估具有低动脉粥样硬化风险特征的专业运动员的CAD患病率。 | 刘莉 叶鹏 Merghani A Maestrini V Rosmini S Cox AT Dhutia H Bastiaenen R David S Yeo TJ Narain R Malhotra A Papadakis M Wilson MG Tome M AlFakih K Moon JC Sharma S | 2017 | 中华高血压杂志2017，25，6： | 8 |
| 3 | 氮氧化物吸附催化器与选择性催化还原装置组合排放控制系统用的先进催化剂显示文摘与仅采用一种技术的系统相比,由氮氧化物(NO_x)吸附催化器(NAC)和选择性催化还原(SCR)装置组合的排放控制系统能够对稀燃条件下的NO_x控制提供更大的优势。然而,组合系统也对新的催化剂设计提出了挑战。与仅采用NAC的系统相比,NO_x再生时,NAC+SCR组合系统中NAC生成的氨(NH_3)是所需的特性。组合系统中的SCR需要与单独的SCR技术一样耐热,同时必须能抵抗上游的NAC周期性脱硫时出现的高温稀/浓状态反复变化。研究中,特别为组合系统研发了先进的NAC和SCR催化剂。改进的NAC催化剂展示出更宽广的运行温度窗口,并在减少铂族金属涂敷量的情况下获得了更高的NH_3生成活性。先进的SCR具有优异的低温NO_x还原效率,即便在高温稀/浓状态反复交替后依然具有极好的耐久性。采用改进的NAC和SCR催化剂后,系统性能显著提高。新研发的催化剂的优势也在车辆上得到了验证。 | Chen H Y Weigert E C Fedeyko J M Cox J P Andersen P J 许蕾 | 2012 | 国外内燃机2012，44，2： | 3 |
| 4 | Co - treatment of H2 S and toluene in a biotrickling filter显示文摘 | Cox H H J A M Deshusses | 2001 | Chemical Engineering Journal2001，3901，： | 1 |
| 5 | Spatial correlation in arbitrary noise fields with application to ambient sea noise显示文摘 | COX H | 1973 | J Acoust Soc Am1973，54，5： | 1 |
| 6 | Mutations of the BRAF gene in human cancer显示文摘 | Bignell GR Cox C | 2002 | Nature2002，417，6892： | 1 |
| 7 | Radial elastic modulus for the interface between FRP reinforcing bars and concrete显示文摘 | Yu H Cox J V | 2002 | Journal of Reinforced Plastics and Composites2002，21，14： | 1 |
| 8 | Mutations of the BRAF gene in human cancer显示文摘 | Davies H Bignell G R Cox C Stephens P Edkins S Clegg S et al | 2002 | Nature2002，417，： | 1 |
| 9 | The elasticity and strength of paper and other fibrous materials显示文摘 | COX H L | 1952 | J Appl Phys1952，3，： | 1 |
| 10 | Relationships Between Protein Composition and Mixograph and Loaf Characteristics in Wheat 显示文摘 | Dong H Sears R G Cox T S | 1992 | Cereal Chem1992，69，2： | 1 |
| 11 | Micromagnetic simulation of ferromagnetic part - spherical particles 显示文摘 | BOARDMAN R P FANGOHR H COX S J | 2004 | J Appl Phys2004，95，11： | 1 |
| 12 | The Elasticity and Strength of Paper and Other Fiberous Materials 显示文摘 | COX H L | 1952 | British Journal of Applied Phys- ics1952，3，3： | 1 |
| 13 | Discrete wavelet transform wignal analyzer显示文摘 | Cox P H CARVALHO A A | 2007 | IEEE Transactions on Instrumentation and Measurement2007，56，5： | 1 |
| 14 | Elastic stress concentration factors, geometric discontinuities in rods and tubes of isotropic materials显示文摘 | | 1970 | Engineering Science Data1970，，： | 1 |
| 15 | Human respiratory syncytial virus vaccine antigen produced in plants 显示文摘 | Fleysh N Cox S | 2000 | FASEB J2000，14，： | 1 |
| 16 | Vibration and audible noise of capacitors subjected to non-sinusoidal waveforms显示文摘 | Cox M D Guan H H | 1994 | IEEE Transactions on Power Delivery1994，9，2： | 1 |
| 17 | Effect of mydriasis and different field strategies on digital image screening of diabetic eye disease 显示文摘 | Murgatroyd H Ellingford A Cox A Binnie M Ellis JD Macewen CJ | 2004 | Br J Ophthalmol2004，88，9： | 1 |
| 18 | C shaped canal configurations in mandibular molar显示文摘 | Cook H G 3rd Cox F L | 1979 | J Am Dent Assoc1979，99，5： | 1 |
| 19 | An investigation of the route and progression of encephalitozoon cuniculi infection in adult rabbits显示文摘 | Cox J C Hamilton R C Attwood H D | 1979 | J Protozool1979，26，1： | 1 |
| 20 | RF fiber-optic link performance显示文摘 | Edward I Ackerman Charles H Cox | 2001 | IEEE microwave magazine2001，，： | 1 |
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