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| 1 | 中国两栖动物保护需求总述显示文摘通过对中国两栖动物物种生物多样性现状的全面分析,与世界许多国家相比,中国是一个重要的全球优先保护地区.横断山区、南岭山区和武夷山区3个区域的两栖动物物种多样性特别丰富.有尾两栖类物种较无尾类受胁程度更高.几个物种数相对较少的铃蟾科、隐腮鲵科、小鲵科和蝾螈科显示出了高的受胁倾向.像世界其它地方一样,高海拔地区溪流繁殖的森林物种受胁程度更高.对中国两栖动物而言,生境丧失、污染和过度捕捉是最主要的致危因素.过度捕捉虽然影响不如生境丧失深远,但它更可能导致一个物种种群的快速衰落.针对5个方面的保护挑战,提出了优先研究领域和保护行动方面的建议. | 谢锋 刘惠宁 Simon N Stuart Janice S Chanson Neil A Cox Debra L Fischman | 2006 | 中国科学(C辑)2006，36，6： | 28 |
| 2 | Conservation needs of amphibians in China: A review显示文摘The conservation status of all the amphibians in China is analyzed,and the country is shown to be a global priority for conservation in comparison to many other countries of the world.Three Chinese regions are particularly rich in amphibian diversity:Hengduan,Nanling,and Wuyi mountains.Sala-manders are more threatened than frogs and toads.Several smaller families show a high propensity to become seriously threatened:Bombinatoridae,Cryptobranchidae,Hynobiidae and Salamandridae.Like other parts of the world,stream-breeding,high-elevation forest amphibians have a much higher likeli-hood of being seriously threatened.Habitat loss,pollution,and over-harvesting are the most serious threats to Chinese amphibians.Over-harvesting is a less pervasive threat than habitat loss,but it is more likely to drive a species into rapid decline.Five conservation challenges are mentioned with recommendations for the highest priority research and conservation actions. | Michael Wai Neng LAU Simon N STUART Janice S CHANSON Neil A COX Debra L FISCHMAN | 2007 | Science China(Life Sciences)2007，50，2： | 12 |
| 3 | Haplotype of prostaglandin synthase 2/cyclooxygenase 2 is involved in the susceptibility to inflammatory bowel disease显示文摘AIM: Prostaglandin G/H synthase 2 (PTGS2 or COX2) is one of the key factors in the cellular response to inflammation.PTGS2 is expressed in the affected intestinal segments of patients with inflammatory bowel diseases (IBD). In IBD patients, non-steroidal anti-inflammatory drugs, which have been shown to reduce both the production and activity of PTGS2, may activate IBD and aggravate the symptoms.We aimed at examining genetic variants of PTGS2 that may be risk factors for IBD.METHODS: We genotyped 291 individuals diagnosed with IBD and 367 controls from the Dutch population for the five most frequent polymorphisms of the PTGS2 gene.Clinical data were collected on all patients. DNA was extracted via normal laboratory methods. Genotyping was carried out using multiplex PCR followed by the Invader Assay and the 5' exonuclease assay (TaqMan). New polymorphism screening was performed by pre-screening with denaturing high-performance liquid chromatography,followed by fluorescent sequencing.RESULTS: Allele 5209G was weakly associated with Crohn's disease (odds ratio [OR] 1.63, 95% confidence interval [CI] 1.03-2.57), and allele 8473T with ulcerative colitis (OR 1.50, 95%CI 1.00-2.27). The haplotype including both alleles showed a strong association with IBD (OR 13.15, 95%CI 3.17-116.15). This haplotype, while rare (-0.3%) in the general population, is found more frequently in patients (3.5%).CONCLUSION: Our data suggest that this haplotype of PTGS2 contributes to the susceptibility of IBD. | David G Cox J Bart A Crusius Petra HM Peeters H Bas Bueno-de-Mesquita A Salvador Pe(n|~)a Federico Canzian | 2005 | World Journal of Gastroenterology2005，11，38： | 10 |
| 4 | Hepatic steatosis and fibrosis: Non-invasive assessment显示文摘Chronic liver disease is a major cause of morbidity and mortality worldwide and usually develops over many years, as a result of chronic inflammation and scarring, resulting in end-stage liver disease and its complications. The progression of disease is characterised by ongoing inflammation and consequent fibrosis, although hepatic steatosis is increasingly being recognised as an important pathological feature of disease, rather than being simply an innocent bystander. However, the current gold standard method of quantifying and staging liver disease, histological analysis by liver biopsy, has several limitations and can have associated morbidity and even mortality. Therefore, there is a clear need for safe and noninvasive assessment modalities to determine hepatic steatosis, inflammation and fibrosis. This review covers key mechanisms and the importance of fibrosis and steatosis in the progression of liver disease. We address non-invasive imaging and blood biomarker assessments that can be used as an alternative to information gained on liver biopsy. | Rustam N Karanjia Mary ME Crossey I Jane Cox Haddy KS Fye Ramou Njie Robert D Goldin Simon D Taylor-Robinson | 2016 | World Journal of Gastroenterology2016，22，45： | 6 |
| 5 | Cecal carriage of Clostri-dinm perfringens in broiler chickens given mucosal starter culture 显示文摘 | Craven S E Stem N J Cox N A | 1999 | Avian Diseases1999，43，： | 1 |
| 6 | Detection of anti body to the foot-and-mouth disease virus (FMDV) non-structural polyprotein 3ABC in sheep by ELISA显示文摘 | Armstrong R M Cox S J Aggarwal N | 2005 | J Virol Meth2005，125，2： | 1 |
| 7 | Influenza 显示文摘 | Cox N J Subbarao K | 1999 | Lancet1999，354，： | 1 |
| 8 | Properties and failure mechanisms of pinned composite lap joints in monotonic and cyclic tension 显示文摘 | CHANG P MOURITZ A P COX B N | 2006 | Composites Science and Technology2006，66，13： | 1 |
| 9 | Genetic variation in the gene encoding calpain-10 is assiociated with type 2 diabetes mellitus显示文摘 | Horikawa YOda N Cox NJ | 2000 | Nat Genet2000，26，2： | 1 |
| 10 | Molecular and biological characterization of human monoclonal antibodies bingding to the spike and nucleocapsid proteins of Severe Acute Respiratory Syndrome Coronavirus显示文摘 | Van den Brink E N Meulen J Cox F | 2005 | J Virol2005，79，： | 1 |
| 11 | Constitutive model for a fiber tow bridging a delamination crack显示文摘 | Cox B N | 1999 | Mechanics of Composite Materials and Structures1999，6，： | 1 |
| 12 | Two-step mucosal competitive exclusion flora treatment to diminish Salmonellae in commercial broiler chickens显示文摘 | Blankenship L C Bailey J S Cox N A | 1993 | Poult Sci1993，72，9： | 1 |
| 13 | Effect of yeast-supplemented feed on Salmonella and Campylobacter populations in broilers显示文摘 | LINE J E BAILEY J S COX N A | 1998 | Poultry Science1998，77，3： | 1 |
| 14 | Integrins as therapeutic tar gets:lessons and opportunities显示文摘 | Cox D Brennan M Moran N | 2010 | Nat Rev Drug Discov2010，9，10： | 1 |
| 15 | Stable and unstable solutions for bridged cracks in various specimens显示文摘 | Cox B N Marshall D B | | 0，，4： | 1 |
| 16 | IL-27 promotes T cell-dependent colitis through multiple mechanisms 显示文摘 | Cox JH Kljavin NM Ramamoorthi N ei al | 2011 | J Exp Med2011，208，1： | 1 |
| 17 | Substrate specificity of the integral membrane protease OmpT determined by spatially addressed peptide libraries 显示文摘 | DEKKER N COX R C KLLLMER R A | 2001 | Biochemistry2001，40，6： | 1 |
| 18 | Human respiratory syncytial virus vaccine antigen produced in plants 显示文摘 | Fleysh N Cox S | 2000 | FASEB J2000，14，： | 1 |
| 19 | A traction law for inclined fibre tows bridging mixed mode cracks显示文摘 | Cox B N Sridhar N | 2002 | Mechanics of Advanced Materials and Structures2002，9，33： | 1 |
| 20 | Directed evolution of ionizing radiation resistance in Escherichia coli 显示文摘 | Harris D R Pollock S V Wood E A Goiffon R J Klingele A J Cabot E L Schackwitz W Martin J Eggington J Durfee T J Middle C M Norton J E Popelars M C Li H Klugman S A Hamilton L L Bane L B Pennacchio L A Albert T J Perna N T Cox M M Battista J R | 2009 | Journal of Bacteriology2009，191，16： | 1 |
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