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| 1 | Inflammatory bowel disease:definition,epidemiology,etiologic aspects,andimmunogenetic studies显示文摘DISEASEDEFINITIONSeveralcausesexistforinflammationofthegutsuchasinfection,toxin,autoimmunereaction,radiationandischemia.Whenn... | XIA Bing 1, JBA Crusius 2, SGM Meuwissen 2 and AS Pe*ka 2 | 1998 | World Journal of Gastroenterology1998，4，5： | 30 |
| 2 | In vitro production of TNFα,IL-6 and sIL-2R in Chinese patients with ulcerative colitis显示文摘InvitroproductionofTNFα,IL6andsIL2RinChinesepatientswithulcerativecolitisXIABing1,GUOHaiJian1,JBACrusius2,DENGChangSheng... | XIA Bing 1, GUO Hai Jian 1, JBA Crusius 2, DENG Chang Sheng 1, SGM Meuwissen 2 and AS Pena 2 | 1998 | World Journal of Gastroenterology1998，4，3： | 18 |
| 3 | Inflammatory bowel disease in Hubei Province of China显示文摘InflammatoryboweldiseaseinHubeiProvinceofChinaXIABing1,S.SHIVANANDA2,ZHANGGuiShui1,YIJiYun1,JBACRUSIUS3andASPEN~A3Subjecthe... | XIA Bing 1, S. SHIVANANDA 2, ZHANG Gui Shui 1, YI Ji Yun 1, JBA CRUSIUS 3 and AS PE N~ A 3 | 1997 | World Journal of Gastroenterology1997，3，2： | 12 |
| 4 | Haplotype of prostaglandin synthase 2/cyclooxygenase 2 is involved in the susceptibility to inflammatory bowel disease显示文摘AIM: Prostaglandin G/H synthase 2 (PTGS2 or COX2) is one of the key factors in the cellular response to inflammation.PTGS2 is expressed in the affected intestinal segments of patients with inflammatory bowel diseases (IBD). In IBD patients, non-steroidal anti-inflammatory drugs, which have been shown to reduce both the production and activity of PTGS2, may activate IBD and aggravate the symptoms.We aimed at examining genetic variants of PTGS2 that may be risk factors for IBD.METHODS: We genotyped 291 individuals diagnosed with IBD and 367 controls from the Dutch population for the five most frequent polymorphisms of the PTGS2 gene.Clinical data were collected on all patients. DNA was extracted via normal laboratory methods. Genotyping was carried out using multiplex PCR followed by the Invader Assay and the 5' exonuclease assay (TaqMan). New polymorphism screening was performed by pre-screening with denaturing high-performance liquid chromatography,followed by fluorescent sequencing.RESULTS: Allele 5209G was weakly associated with Crohn's disease (odds ratio [OR] 1.63, 95% confidence interval [CI] 1.03-2.57), and allele 8473T with ulcerative colitis (OR 1.50, 95%CI 1.00-2.27). The haplotype including both alleles showed a strong association with IBD (OR 13.15, 95%CI 3.17-116.15). This haplotype, while rare (-0.3%) in the general population, is found more frequently in patients (3.5%).CONCLUSION: Our data suggest that this haplotype of PTGS2 contributes to the susceptibility of IBD. | David G Cox J Bart A Crusius Petra HM Peeters H Bas Bueno-de-Mesquita A Salvador Pe(n|~)a Federico Canzian | 2005 | World Journal of Gastroenterology2005，11，38： | 10 |
| 5 | Combined carriership of TLR9 -1237C and CD14 -260T alleles enhances the risk of developing chronic relapsing pouchitis显示文摘AIM: To investigate the single nucleotide polymorphisms (SNPs) in genes involved in bacterial recognition and the susceptibility to pouchitis or pouchitis severity.METHODS: Analyses of CD14 -260C>T, CARD15/NOD2 3020insC, Toll-like receptor (TLR)4 +896A>G,TLR9 -1237T>C, TLR9+ 2848G>A, and IRAKM +22148G>A SNPs were performed in 157 ileal-pouch anal anastomosis (IPAA) patients (79 patients who did not develop pouchitis, 43 infrequent pouchitis patients,35 chronic relapsing pouchitis patients) and 224 Italian Caucasian healthy controls.RESULTS: No significant differences were found in SNP frequencies between controls and IPAA patients.However, a significant difference in carriership frequency of the TLR9-1237C allele was found between the infrequent pouchitis and chronic relapsing pouchitis groups [P = 0.028, odd's ratio (OR) = 3.2, 95%CI = 1.2-8.6].This allele uniquely represented a 4-locus TLR9 haplotype comprising both studied TLR9 SNPs in Caucasians.Carrier trait analysis revealed an enhanced combined carriership of the alleles TLR9 -1237C and CD14 -260T in the chronic relapsing pouchitis and infrequent pouchitis group (P = 0.018, OR = 4.1, 95%CI = 1.4 -12.3).CONCLUSION: There is no evidence that the SNPs predispose to the need for IPAA surgery. The significant increase of the combined carriership of the CD14 -260T and TLR9 -1237C alleles in the chronic relapsing pouchitis group suggests that these markers identify a subgroup of IPAA patients with a risk of developing chronic or refractory pouchitis. | KM Lammers S Ouburg SA Morré JBA Crusius P Gionchetti F Rizzello C Morselli E Caramelli R Conte G Poggioli M Campieri AS Pea | 2005 | World Journal of Gastroenterology2005，11，46： | 7 |
| 6 | Effect of B vitamin supplementation on plasma homocysteine levels in celiac disease显示文摘AIM: To investigate the effect of vitamin supplements on homocysteine levels in patients with celiac disease. METHODS: Vitamin B6, folate, vitamin B12, and fasting plasma homocysteine levels were measured in 51 consecutive adults with celiac disease [median (range) age 56 (18-63) years; 40% men, 26 (51%) had villous atrophy, and 25 (49%) used B-vitamin supplements] and 50 healthy control individuals matched for age and sex. Finally, the C677T polymorphism of 5,10-methylene tetrahydrofolate reductase (MTHFR) was evaluated in 46 patients with celiac disease and all control individuals. RESULTS: Patients with celiac disease and using vitamin supplements had higher serum vitamin B6 (P = 0.003),folate (P < 0.001), and vitamin B12 (P = 0.012) levels than patients who did not or healthy controls (P = 0.035, P < 0.001, P = 0.007, for vitamin B6, folate, and vitamin B12, respectively). Lower plasma homocysteine levels were found in patients using vitamin supplements than in patients who did not (P = 0.001) or healthy controls (P = 0.003). However, vitamin B6 and folate, not vitamin B12, were significantly and independently associated with homocysteine levels. Twenty-four (48%) of 50 controls and 23 (50%) of 46 patients with celiac disease carried the MTHFR thermolabile variant T-allele (P = 0.89). CONCLUSION: Homocysteine levels are dependent on Marsh classification and the regular use of B-vitamin supplements is effective in reduction of homocysteine levels in patients with celiac disease and should be considered in disease management. | Muhammed Hadithi Chris JJ Mulder Frank Stam Joshan Azizi J Bart A Crusius Amado Salvador Pea Coen DA Stehouwer Yvo M Smulders | 2009 | World Journal of Gastroenterology2009，15，8： | 3 |
| 7 | Associatlon of inter-leukin- lβand interleukin-1 receptor antagonist genes with disease se-verity in MS显示文摘 | Schrijver HM Crusius JBA Uitdehaag BMJ | 1999 | Neurology1999，52，3： | 1 |
| 8 | Gas transfer velocities measured at low wind speed over a lake 显示文摘 | CRUSIUS J WANNINKHOF R | 2003 | Limnology and Oceanography2003，48，3： | 1 |
| 9 | CTLA-4 gene polymorphisms in Dutch and Chinese patients with inflammatory bowel disease显示文摘 | Xia B Crusius JBA Wu J | 2002 | Stand J Gastroenterol2002，37，： | 1 |
| 10 | Comparative behavior of authigenic Re, U and Mo during reoxidation and subsequent long-term burial in marine sediments 显示文摘 | CRUSIUS J THOMSON J | 2000 | Geochimica et Cosmochimica Acta2000，64，： | 1 |
| 11 | Allelic polymorphism in IL-1β and IL-1 receptor antagonist(IL-1Ra) genes in inflammatory bowel disease显示文摘 | Bioque G Crusius JB Koutroubakis I | 1995 | Clin Exp Immunol1995，102，2： | 1 |
| 12 | Allelic polymorphism in IL-1 beta and IL-1 recep- tor antagonist (IL-1Ra) genes in inflammatory bowel disease显示文摘 | BIOQUE G CRUSIUS J B KOUTROUBAKIS I | 1995 | Clin Exp Immunol1995，102，： | 1 |
| 13 | Secretion of tumor necrosis factor alpha and lymphotoxin alpha in relation to polymorphisms in the TNF genes and HLA-DR alleles:relevance for inflammatory bowel disease显示文摘 | Bouma G Crusius JBA Oudkerk PM | 1996 | Scand J Immunol1996，43，： | 1 |
| 14 | The human papillomavirus type 16 ES-protein modulates ligand-dependent activation of the EGF receptor family in the human epithelial cell line HaCaT 显示文摘 | Crusius K Auvinen E Steuer B | 1998 | Exp Cell Res1998，241，1： | 1 |
| 15 | Sufficient LMI conditions for output feedback control problems显示文摘 | Crusius C A R Trofino A | 1999 | IEEE Transactions on Automatic Control1999，44，5： | 1 |
| 16 | Interleukin-12p40 genotype plays a role in the susceptibility to multiple sclerosis显示文摘 | van Veen T Crusius JB Schrijver HM | 2001 | Ann Neurol2001，50，： | 1 |
| 17 | Allelic polymorphism in IL-113and IL-1 receptor antagonist (IL-1Ra) genes in inflammatory bowel disease显示文摘 | Bioque G Crusius JBA Koutroubakis I | 1995 | Clin Exp Immunol1995，102，2： | 1 |
| 18 | Allelic polymorphism in IL-1β and IL-1 receptor antagonist(IL-1 Ra) genes in inflammatory bowel disease显示文摘 | Bioque G Crusius J B A Koutroubakis I | 1995 | Clin Exp Immunol1995，102，6： | 1 |
| 19 | Tab2,a novel recombinant polypeptide tag offering sensitive and specific protein detection and reliable affinity purification 显示文摘 | Crusius K Finster S McClary J | 2006 | Gene2006，380，2： | 1 |
| 20 | Secretion of tumour necrosis factor alpha and lymphotoxin alpha in relation to polymorphisms in the TNF genes and HLA-DR alleles: relevance for inflammatory bowel disease显示文摘 | Bouma G Crusius JB Oudkerk Pool M | 1996 | Scand J Immunol1996，43，： | 1 |
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