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| 1 | Additive manufacturing technology for porous metal implant applications and triple minimal surface structures: A review显示文摘Recently,the fabrication methods of orthopedic implants and devices have been greatly developed.Additive manufacturing technology allows the production of complex structures with bio-mimicry features,and has the potential to overcome the limitations of conventional fabrication methods.This review explores open-cellular structural design for porous metal implant applications,in relation to the mechanical properties,biocompatibility,and biodegradability.Several types of additive manufacturing techniques including selective laser sintering,selective laser melting,and electron beam melting,are discussed for different applications.Additive manufacturing through powder bed fusion shows great potential for the fabrication of high-quality porous metal implants.However,the powder bed fusion technique still faces two major challenges:it is high cost and timeconsuming.In addition,triply periodic minimal surface(TPMS)structures are also analyzed in this paper,targeting the design of metal implants with an enhanced biomorphic environment. | Li Yuan Songlin Ding Cuie Wen | 2019 | Bioactive Materials2019，4，1： | 24 |
| 2 | Recent research and progress of biodegradable zinc alloys and composites for biomedical applications: Biomechanical and biocorrosion perspectives显示文摘Biodegradable metals(BMs)gradually degrade in vivo by releasing corrosion products once exposed to the physiological environment in the body.Complete dissolution of biodegradable implants assists tissue healing,with no implant residues in the surrounding tissues.In recent years,three classes of BMs have been extensively investigated,including magnesium(Mg)-based,iron(Fe)-based,and zinc(Zn)-based BMs.Among these three BMs,Mg-based materials have undergone the most clinical trials.However,Mg-based BMs generally exhibit faster degradation rates,which may not match the healing periods for bone tissue,whereas Fe-based BMs exhibit slower and less complete in vivo degradation.Zn-based BMs are now considered a new class of BMs due to their intermediate degradation rates,which fall between those of Mg-based BMs and Fe-based BMs,thus requiring extensive research to validate their suitability for biomedical applications.In the present study,recent research and development on Zn-based BMs are reviewed in conjunction with discussion of their advantages and limitations in relation to existing BMs.The underlying roles of alloy composition,microstructure,and processing technique on the mechanical and corrosion properties of Zn-based BMs are also discussed. | Humayun Kabir Khurram Munir Cuie Wen Yuncang Li | 2021 | Bioactive Materials2021，6，3： | 18 |
| 3 | A high precision calibration method for long baseline acoustic positioning systems显示文摘To solve the problem that traditional long baseline(LBL) positioning system is easily affected by severe sound speed varying results in low calibration precision, low efficiency and inconsistent position using different references, we propose a high precision array calibration method. We use distances between beacons to build error adjustment model. This model improves the calibration performance of traditional calibration method. The theory shows this method can achieve equal calibration precision with distance measurement precision in horizon. This method can improve the calibration efficiency, solve position ambiguity and achieve high precision especially in deep ocean. The shallow water experiment shows this method has millimeter calibration precision which is equal to distance measurement error. The calibration precision improves from centimeter to millimeter compared to traditional calibration method.The method also decreases the operation complexity. The localized positions are more close to GPS compared to traditional method, which has great application values. | HAN Yunfeng ZHENG Cuie SUN Dajun | 2017 | Chinese Journal of Acoustics2017，36，4： | 11 |
| 4 | Additive manufacturing of metallic and polymeric load-bearing biomaterials using laser powder bed fusion:A review显示文摘Surgical prostheses and implants used in hard-tissue engineering should satisfy all the clinical,mechanical,manufacturing,and economic requirements in order to be used for load-bearing applications.Metals,and to a lesser extent,polymers are promising materials that have long been used as load-bearing biomaterials.With the rapid development of additive manufacturing(AM)technology,metallic and polymeric implants with complex structures that were once impractical to manufacture using traditional processing methods can now easily be made by AM.This technology has emerged over the past four decades as a rapid and cost-effective fabrication method for geometrically complex implants with high levels of accuracy and precision.The ability to design and fabricate patient-specific,customized structural biomaterials has made AM a subject of great interest in both research and clinical settings.Among different AM methods,laser powder bed fusion(L-PBF)is emerging as the most popular and reliable AM method for producing load-bearing biomaterials.This layer-by-layer process uses a high-energy laser beam to sinter or melt powders into a part patterned by a computer-aided design(CAD)model.The most important load-bearing applications of L-PBF-manufactured biomaterials include orthopedic,traumatological,craniofacial,maxillofacial,and dental applications.The unequalled design freedom of AM technology,and L-PBF in particular,also allows fabrication of complex and customized metallic and polymeric scaffolds by altering the topology and controlling the macro-porosity of the implant.This article gives an overview of the L-PBF method for the fabrication of load-bearing metallic and polymeric biomaterials. | Alireza Nouri Anahita Rohani Shirvan Yuncang Li Cuie Wen | 2021 | Journal of Materials Science & Technology2021，，35： | 9 |
| 5 | Graphene nanoplatelets-reinforced magnesium metal matrix nanocomposites with superior mechanical and corrosion performance for biomedical applications显示文摘Magnesium(Mg)metal matrix composites(MMCs)reinforced with graphene nanoplatelets(GNPs)have been developed by powder metallurgy(PM).GNPs with different concentrations(0.1,0.2,and 0.3 wt.%),layer thicknesses(5 nm and 9 nm),and particle sizes(15μm and 5μm)were dispersed into Mg powder by high-energy ball-milling processes.The microstructure and mechanical properties of the fabricated composites were characterized using transmission electron microscopy(TEM),scanning electron microscopy(SEM),energy dispersive X-ray spectroscopy(EDX),X-ray diffraction(XRD),Raman spectroscopy(RS),and compression tests.The corrosion resistance was evaluated by electrochemical tests and hydrogen evolution measurements.The cytotoxicity of Mg-GNPs composites was assessed using osteoblast-like SaOS2 cells.The results indicate that GNPs are excellent candidates as reinforcements in Mg matrices for the manufacture of biodegradable Mg-based composite implants.GNP addition improved the mechanical properties of Mg via synergetic strengthening modes.Moreover,retaining the structural integrity of GNPs during processing improved the ductility,compressive strength,and corrosion resistance of the Mg-GNP composites.Cytotoxicity assessments did not reveal any significant toxicity with the addition of GNPs to Mg matrices.This study demonstrates that Mg-xGNPs with x<0.3 wt.%,may constitute novel biodegradable implant materials for load-bearing applications. | Khurram Munir Cuie Wen Yuncang Li | 2020 | Journal of Magnesium and Alloys2020，8，1： | 8 |
| 6 | Recent Progress on Data-Based Optimization for MineralProcessing Plants显示文摘In the globalized market environment, increasingly significant economic and environmental factors withincomplex industrial plants impose importance on the optimization of global production indices; such opti-mization includes improvements in production efficiency, product quality, and yield, along with reductionsof energy and resource usage. This paper briefly overviews recent progress in data-driven hybrid intelli-gence optimization methods and technologies in improving the performance of global production indicesin mineral processing. First, we provide the problem description. Next, we summarize recent progress indata-based optimization for mineral processing plants. This optimization consists of four layers: optimiza-tion of the target values for monthly global production indices, optimization of the target values for dailyglobal production indices, optimization of the target values for operational indices, and automation systemsfor unit processes. We briefly overview recent progress in each of the different layers. Finally, we point outopportunities for future works in data-based optimization for mineral processing plants. | Jinliang Ding Cuie Yang Tianyou Chai | 2017 | Engineering2017，3，2： | 7 |
| 7 | A review of high-strength nanolaminates and evaluation of their properties显示文摘Nanolaminates are composed of nanoscale-thick alternating layers of different materials and their properties are dependent on the individual layers,the layer thickness and the interfaces between the layers.Nanolaminates composed of cubic crystal structured metals are usually ductile compared to nanolaminates containing hexagonal crystal structured metals.Mechanical properties such as strength and hardness of nanolaminates increase with a decrease in individual layer thickness down to a few nanometers and they become independent when the thickness of individual layers is less than a couple of nanometers.This review provides a detailed analysis of the effects of individual layer thickness and the interface structures on the strength and the strengthening mecha nisms of nanolaminates,their ductility and fracture behavior in terms of structural variations including grain morphologies,nanotwins,amorphous phases and crystal structures of the layers.The principles for designing nanolaminates with exceptionally high mechanical and physical properties and their fabrication are also highlighted.Some contradictory issues such as strengthening mechanisms,elastic modulus dependency on individual layer thickness and the effect of a thin amorphous layer on the strength are discussed.This review also provides future research directions in designing the high-strength nanolaminates that will facilitate practical engineering applications through analyzing up-to-date research efforts. | Mohammad Nasim Yuncang Li Ming Wen Cuie Wen | 2020 | Journal of Materials Science & Technology2020，47，15： | 6 |
| 8 | 锂离子电池硅负极初始库仑效率的研究进展显示文摘硅被认为是最有前景的锂离子负极材料之一,具有比容量高,电位平台低,储量丰富等优势,但初始库仑效率低等问题限制了其在锂离子电池中的应用。为此,本文通过文献调研研究了初始库伦效率偏低的内在机理,着重从包覆、预锂化、纳米化、电解液改性等技术综述提高硅负极材料的初始库仑效率的方法并对未来发展趋势做了简单的展望。 | 王帅 宋广生 Cuie Wen 马扬洲 | 2020 | 功能材料2020，51，11： | 5 |
| 9 | HA coating on Mg alloys for biomedical applications:A review显示文摘Magnesium(Mg)alloys are receiving increasing attention as biodegradable implant materials in recent years.However,their low corrosion resistance and fast degradation in the physiological environment remain challenges for a widespread application.Hydroxyapatite(HA)coating on Mg alloys can enhance their corrosion resistance,biocompatibility,and bioactivity of the Mg alloy substrates since the compositions of HA are similar to those of the hard tissue of natural bone.This review analyzes the challenges of Mg alloys for biomedical applications,the fundamental requirements for biodegradable metals,and the corrosion mechanisms of Mg alloys in the physiological environment.The benefits of HA coatings on Mg alloys,the most commonly used surface coating techniques and their advantages and limitations,and the in vitro and in vivo performance of Mg alloys with and without surface coatings are comprehensively elucidated.Multistep processes such as alkali treatment and then HA coating by electrochemical deposition on Mg alloys appear to be necessary to achieve a satisfactory surface coating on Mg alloys,which has been demonstrated to have the potential to improve the degrading behavior,bioactivity and biocompatibility.Multifunctional coatings are most effective in achieving safe and bioactive Mg alloy surfaces for promising biodegradable implant applications. | Mostafizur Rahman Yuncang Li Cuie Wen | 2020 | Journal of Magnesium and Alloys2020，8，3： | 4 |
| 10 | Improvement of Seafloor Positioning Through Correction of Sound Speed Profile Temporal Variation显示文摘Dear Editor,This letter proposes a high-precision seafloor transponder positioning method based on the correction of sound speed profile(SSP)temporal variation.In the proposed method,the ocean sound speed error is modeled as the temporal variation of a background SSP,and the linearized expression of the acoustic travel time with respect to the sound speed coefficient is derived based on the ray acoustic model.Moreover,the proposed method introduces the constraint of acoustic ranging observations between seafloor transponders and determines the weights of travel time and ranging observations using Akaike’s Bayesian information criterion(ABIC)to reduce the positioning error caused by the correlation between sound speed and position parameters.The experimental results in the South China Sea show that the proposed method performs better than the global navigation satellite system-acoustic ranging combined positioning solver(GARPOS)[1],in terms of rigid distance errors and long baseline positioning accuracy. | Miao Yu Kuijie Cai Cuie Zheng Dajun Sun | 2023 | IEEE/CAA Journal of Automatica Sinica2023，10，4： | 3 |
| 11 | A comprehensive review of biodegradable synthetic polymer-ceramic composites and their manufacture for biomedical applications显示文摘The application of various materials in biomedical procedures has recently experienced rapid growth.One area that is currently receiving significant attention from the scientific community is the treatment of a number of different types of bone-related diseases and disorders by using biodegradable polymer-ceramic composites.Biomaterials,the most common materials used to repair or replace damaged parts of the human body,can be categorized into three major groups:metals,ceramics,and polymers.Composites can be manufactured by combining two or more materials to achieve enhanced biocompatibility and biomechanical properties for specific applications.Biomaterials must display suitable properties for their applications,about strength,durability,and biological influence.Metals and their alloys such as titanium,stainless steel,and cobalt-based alloys have been widely investigated for implant-device applications because of their excellent mechanical properties.However,these materials may also manifest biological issues such as toxicity,poor tissue adhesion and stress shielding effect due to their high elastic modulus.To mitigate these issues,hydroxyapatite(HA)coatings have been used on metals because their chemical composition is similar to that of bone and teeth.Recently,a wide range of synthetic polymers such as poly(L-lactic acid)and poly(L-lactide-co-glycolide)have been studied for different biomedical applications,owing to their promising biocompatibility and biodegradability.This article gives an overview of synthetic polymer-ceramic composites with a particular emphasis on calcium phosphate group and their potential applications in tissue engineering.It is hoped that synthetic polymer-ceramic composites such as PLLA/HA and PCL/HA will provide advantages such as eliminating the stress shielding effect and the consequent need for revision surgery. | Mona Alizadeh-Osgouei Yuncang Li Cuie Wen | 2019 | Bioactive Materials2019，4，1： | 3 |
| 12 | Biodegradable Zn–3Cu and Zn–3Cu–0.2Ti alloys with ultrahigh ductility and antibacterial ability for orthopedic applications显示文摘Zinc(Zn) and its alloys have been proposed as biodegradable implant materials due to their unique combination of biodegradability, biocompatibility, and biofunctionality. However, the insufficient mechanical properties of pure Zn greatly limit its clinical application. Here, we report on the microstructure, mechanical properties, friction and wear behavior, corrosion and degradation properties, hemocompatibility, and cytocompatibility of Zn–3 Cu and Zn–3 Cu–0.2 Ti alloys under three different conditions of as-cast(AC),hot-rolling(HR), and hot-rolling plus cold-rolling(HR + CR). The HR + CR Zn–3 Cu–0.2 Ti exhibited the best set of comprehensive properties among all the alloy samples, with yield strength of 211.0 MPa, ultimate strength of 271.1 MPa, and elongation of 72.1 %. Immersion tests of the Zn–3 Cu and Zn–3 Cu–0.2 Ti alloys in Hanks’ solution for 3 months indicated that the AC samples showed the lowest degradation rate,followed by the HR samples, and then the HR + CR samples, while the HR + CR Zn–3 Cu exhibited the highest degradation rate of 23.9 m/a. Friction and wear testing of the Zn–3 Cu and Zn–3 Cu–0.2 Ti alloys in Hanks’ solution indicated that the AC samples showed the highest wear resistance, followed by the HR samples, and then the HR + CR samples, while the AC Zn–3 Cu–0.2 Ti showed the highest wear resistance.The diluted extracts of HR + CR Zn–3 Cu and Zn–3 Cu–0.2 Ti at a concentration of ≤25 % exhibited noncytotoxicity. Furthermore, both the HR + CR Zn–3 Cu and Zn–3 Cu–0.2 Ti exhibited effective antibacterial properties against S. aureus. | Jixing Lin Xian Tong Kun Wang Zimu Shi Yuncang Li Matthew Dargusch Cuie Wen | 2021 | Journal of Materials Science & Technology2021，，9： | 3 |
| 13 | Nano-tribological behavior of graphene nanoplatelet-reinforced magnesium matrix nanocomposites显示文摘The corrosion resistance and wear resistance of metallic biomaterials are critically important for orthopedic hard-tissue replacement applications because the lack of such properties not only adversely affects their mechanical integrity but also allows the release of wear debris into the human body.In this study,the potential of zirconium(Zr)as an alloying element and graphene nanoplatelets(GNPs)as a nano-reinforcement material were investigated in relation to improving the tribological performance of pure magnesium(Mg).The GNPs-reinforced Mg matrix nanocomposites(MNCs)were fabricated using powder metallurgy.Results indicate that additions of 0.5 wt.%Zr and0.1 wt.%GNPs to Mg matrices significantly improved the wear resistance by 89%and 92%at 200μN load,60%and 80%at 100μN load,and 94%and 93%at 50μN load,respectively,as compared to the wear resistance of pure Mg.The wear depth and coefficient of friction of the MNC containing 0.5 wt.%Zr and 0.1 wt.%GNPs(Mg0.5 Zr0.1 GNPs MNC)were considerably reduced as compared to pure Mg and Mg0.5 Zr.Our results demonstrate that the Mg0.5 Zr0.1 GNPs MNC is promising for orthopedic applications in relation to its excellent tribological performance. | Mohammad Shahin Khurram Munir Cuie Wen Yuncang Li | 2021 | Journal of Magnesium and Alloys2021，9，3： | 2 |
| 14 | The influence of Ca and Cu additions on the microstructure,mechanical and degradation properties of Zn-Ca-Cu alloys for absorbable wound closure device applications显示文摘Novel ternary Zn-Ca-Cu alloys were studied for the development of absorbable wound closure device material due to Ca and Cu’s therapeutic values to wound healing.The influence of Ca and Cu on the microstructure,mechanical and degradation properties of Zn were investigated in the as-cast state to establish the fundamental understanding on the Zn-Ca-Cu alloy system.The microstructure of Zn-0.5Ca-0.5Cu,Zn-1.0Ca-0.5Cu,and Zn0.5Ca-1.0Cu is composed of intermetallic phase CaZn13 distributed within the Zn-Cu solid solution.The presence of CaZn13 phase and Cu as solute within the Zn matrix,on the one hand,exhibited a synergistic effect on the grain refinement of Zn,reducing the grain size of pure Zn by 96%;on the other hand,improved the mechanical properties of the ternary alloys through solid solution strengthening,second phase strengthening,and grain refinement.The degradation properties of Zn-Ca-Cu alloys are primarily influenced by the micro-galvanic corrosion between Zn-Cu matrix and CaZn13 phase,where the 0.5%and 1.0%Ca addition increased the corrosion rate of Zn from 11.5μm/y to 19.8μm/y and 29.6μm/y during 4 weeks immersion test. | Nan Yang Nagasivamuni Balasubramani Jeffrey Venezuela Sharifah Almathami Cuie Wen Matthew Dargusch | 2021 | Bioactive Materials2021，6，5： | 2 |
| 15 | 锂离子电池硅基负极材料预锂化技术的研究进展显示文摘硅基负极材料由于具有比容量高、安全及商业发展前景好等优点而受到业界广泛关注,但锂离子电池硅基负极存在循环寿命短和首次库仑效率低等问题,采用硅基负极预锂化技术可有效改善这类问题。综述硅基负极材料预锂化技术的最新研究进展,着重阐述稳定的金属锂粉末、电化学预锂化、添加剂预锂化及机械预锂化等技术,并展望未来硅基负极预锂化的研究方向。 | 宋广生 金磊 Cuie Wen 马扬洲 | 2019 | 安徽工业大学学报(自然科学版)2019，36，3： | 2 |
| 16 | Manufacturing of graded titanium scaffolds using a novel space holder technique显示文摘To optimize both the mechanical and biological properties of titanium for biomedical implants,a highly flexible powder metallurgy approach is proposed to generate porous scaffolds with graded porosities and pore sizes.Sugar pellets acting as space holders were compacted with titanium powder and then removed by dissolution in water before sintering.The morphology,pore structure,porosity and pore interconnectivity were observed by optical microscopy and SEM.The results show that the porous titanium has porosity levels and pore size gradients consistent with their design with gradual and smooth transitions at the interfaces between regions of differing porosities and/or pore sizes.Meanwhile,the porous titanium has high interconnectivity between pores and highly spherical pore shapes.In this article we show that this powder metallurgy processing technique,employing the novel sugar pellets as space-holders,can generate porous titanium foams with well-controlled graded porosities and pore sizes.This method has excellent potential for producing porous titanium structures for hard tissue engineering applications. | Yunhui Chen Damon Kent Michael Bermingham Ali Dehghan-Manshadi Gui Wang Cuie Wen Matthew Dargusch | 2017 | Bioactive Materials2017，2，4： | 2 |
| 17 | Characterization of folate-chitosan-DNA nanoparticles for gene therapy显示文摘 | Mansouri S Cuie Y Winnik F | 2006 | Biomaterials2006，27，9： | 1 |
| 18 | Differences in subcellular distribution and toxicity of green and red emitting CdTe quantum dots显示文摘 | Lovric J Bazzih S Cuie Y | 2005 | J Mol Med2005，83，5： | 1 |
| 19 | Gene mapping of a new coat mutation in mouse显示文摘Gene mapping of a mouse coat mutation has been investigated. First, 100 10-bp random primers were used to amplify DNA, but the mutation could not be located by this method because there were no correlation between the amplified products and coat phenotypes. Second, by using ldh1 , Car2, Mup1 , Pgb1 , Hbb, Es1O, Es1, Mod1, Gdc1 , Ce2, Es3 as genetic markers, linkage test crosses (two-point test) consisting of intercrossing uncovered BALB/c mice (homozygotes) to CBA/N and C57BL/6 mice with normal hair and backcrossing the heterozygotes of the F1 to the uncovered BALB/c mice were made. It was soon evident that the mutation was linked to Es3 on chromosome 11. Furthermore, three-point test was made by using Es3 and D11 Mit8 (a microsatellite DNA) as genetic markers. The result showed that the mutation was linked to Es3 with the percentage recombination of (7.89 ± 2.19) %, and linked to D11Mit8 with the percentage recombination of (26.30 ± 3.57)%. The percentage recombination between Es3 and D11Mit8 was | Shanru Li Dongping Wang Hong Lan Wenyan Zhang Baosheng Ge Jiqing Li Cuie Wang Yifan Lu Yanyan Shi Runfang Li | 1999 | Chinese Science Bulletin1999，44，13： | 1 |
| 20 | Characterization of folatechitosan-DNA nanoparticles for gene therapy 显示文摘 | Mansouri S Cuie Y Winnik F | 2006 | Biomaterials2006，27，9： | 1 |
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