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| 1 | Relationship between angiotensin-(1-7) and angiotensin Ⅱ correlates with hemodynamic changes in human liver cirrhosis显示文摘AIM:To measure circulating angiotensins at different stages ofhuman cirrhosis and to further evaluate a possible relationship between renin angiotensin system (RAS) components and hemodynamic changes.METHODS: Patients were allocated into 4 groups: mild-to-moderate liver disease (MLD), advanced liver disease (ALD), patients undergoing liver transplantation, and healthy controls. Blood was collected to determine plasma renin activity (PRA), angiotensin (Ang) , Ang Ⅱ, and Ang-(1-7) levels using radioimmunoassays. During liver transplantation, hemodynamic parameters were determined and blood was simultaneously obtained from the portal vein and radial artery in order to measure RAS components.RESULTS: PRA and angiotensins were elevated in ALD when compared to MLD and controls (P < 0.05). In contrast, Ang was signicantly reduced in MLD. Ang-(1-7)/Ang Ⅱ ratios were increased in MLD when compared to controls and ALD. During transplantation, Ang Ⅱ levels were lower and Ang-(1-7)/Ang Ⅱ ratios were higher in the splanchnic circulation than in the peripheral circulation (0.52 ± 0.08 vs 0.38 ± 0.04, P < 0.02), whereas the peripheral circulating Ang /Ang ratio was elevated in comparison to splanchnic lev-els (0.18 ± 0.02 vs 0.13 ± 0.02, P < 0.04). Ang-(1-7)/Ang Ⅱ ratios positively correlated with cardiac output (r= 0.66) and negatively correlated with systemic vascular resistance (r =-0.70).CONCLUSION: Our ndings suggest that the relation-ship between Ang-(1-7) and Ang Ⅱmay play a role in the hemodynamic changes ofhuman cirrhosis. | Walkíria Wingester Vilas-Boas Antnio Ribeiro-Oliveira Jr Regina Maria Pereira Renata da Cunha Ribeiro Jerusa Almeida Ana Paula Nadu Ana Cristina Simoes e Silva Robson Augusto Souza dos Santos | 2009 | World Journal of Gastroenterology2009，15，20： | 11 |
| 2 | Effect of propranolol on the splanchnic and peripheral renin angiotensin system in cirrhotic patients显示文摘AIM:To evaluate the effect of β-blockade on angiotensins in the splanchnic and peripheral circulation of cirrhotic patients and also to compare hemodynamic parameters during liver transplantation according to propranolol pre-treatment or not. METHODS:Patients were allocated into two groups:outpatients with advanced liver disease(LD) and during liver transplantation(LT). Both groups were subdivided according to treatment with propranolol or not. Plasma was collected through peripheral venipuncture to determine plasma renin activity(PRA),Angiotensin(Ang) Ⅰ,Ang Ⅱ,and Ang-(1-7) levels by radioimmunoassay in LD group. During liver transplantation,hemodynamic parameters were determined and blood samples were obtained from the portal vein to measure renin angiotensin system(RAS) components.RESULTS:PRA,Ang Ⅰ,Ang Ⅱ and Ang-(1-7) were signifi cantly lower in the portal vein and periphery in all subgroups treated with propranolol as compared to non-treated. The relationships between Ang-(1-7) and Ang Ⅰ levels and between Ang Ⅱ and Ang Ⅰ were significantly increased in LD group receiving propranolol. The ratio between Ang-(1-7) and Ang Ⅱ remained unchanged in splanchnic and peripheral circulation in patients under β-blockade,whereas the relationship between Ang Ⅱ and Ang Ⅰ was significantly increased in splanchnic circulation of LT patients treated with propranolol. During liver transplantation,cardiac output and index as well systemic vascular resistance and index were reduced in propranolol-treated subgroup. CONCLUSION:In LD group,propranolol treatment reduced RAS mediators,but did not change the ratio between Ang-(1-7) and Ang Ⅱ in splanchnic and peripheral circulation. Furthermore,the modification of hemodynamic parameters in propranolol treated patients was not associated with changes in the angiotensin ratio. | Walkíria Wingester Vilas-Boas Antnio Ribeiro-Oliveira Jr Renata da Cunha Ribeiro Renata Lúcia Pereira Vieira Jerusa Almeida Ana Paula Nadu Ana Cristina Sim■es e Silva Robson Augusto Souza Santos | 2008 | World Journal of Gastroenterology2008，14，44： | 2 |
| 3 | Multiloop edgewise archwire in the treatment of a patient with an anterior open bite and a long face显示文摘 | Ribeiro GL Regis S Jr da Cunha Tde M | 2010 | Am J Orthod Dentofacial Orthop2010，138，1： | 1 |
| 4 | Do trauma patients with a Glasgow Coma Scale score of 3 and dilated pupils have any chance of survival显示文摘 | Tien HC Cunha JR WuSN | 2006 | J Trauma2006，60，： | 1 |
| 5 | Genomic expression, Chemotherapy response, and molecular targets in soft tissue sarcomas of the extremities: promising strategies for treatment selection 显示文摘 | Agiar S JR Cunha IWD Lopes A | 2010 | Journal of Surgical Oncology2010，101，： | 1 |
| 6 | Growth phase-depedent subcellular localization of nitric oxide synthase in maize cells显示文摘 | RIBEIRO E A Jr CUNHA F Q TAMASHIRO W M S C | 1999 | FEBS Lett1999，445，： | 1 |
| 7 | Gait outcomes after acute stroke rehabilitation with supported treadmill ambulation training:a randomized controlled pilot study 显示文摘 | da Cunha IT Jr Lim PA Qureshy H | 2002 | Arch Phys Med Rehabil2002，83，9： | 1 |
| 8 | Do trauma patients with a Glas- gow coma Scale score of 3 and bilateral fixed and dilated pupils have any chance of survival 显示文摘 | Tien HC Cunha JR Wu SN | 2006 | Trauma2006，60，2： | 1 |
| 9 | Crucial role of neutrophils in the development of mechanical inflammatory hypernociception显示文摘 | Cunha TM Verri WA Jr Schivo IR | 2008 | J Leukoc Biol2008，84，4： | 1 |
| 10 | Multiloop edgewise archwire in the treatment of a patient with an anterior open bite and a long face 显示文摘 | Ribeiro GL Regis S Jr da Cunha Tde M | 2010 | Am J Orthod Dentofacial Orthop2010，138，1： | 1 |
| 11 | A quantitative approach to measure joint pain in experimental osteoarthfitis-evidence of a role for nitric oxide显示文摘 | Castro RR Cunha FQ Silva FS Jr | 2006 | Osteoarthritis Cartilage2006，14，8： | 1 |
| 12 | Growth phase dependent subeellular localization of nitric oxide synthase in maize cells显示文摘 | Ribeim E A Jr Cunha F Q Tamashiro W M S | 1999 | FEBS Lett1999，445，： | 1 |
| 13 | Gait outcomes af- ter acute stroke rehabilitation with supported treadmill ambu- lation training: a randomized controlled pilot study显示文摘 | da Cunha IT jr Lim PA Qureshy H | 2002 | Arch Phys Med Rehabil2002，83，： | 1 |
| 14 | Toll-like receptor 2/MyD88 signaling mediates zymosan-induced joint hy- pernociception in mice: participation of TNF-alpha, IL-lbeta and CXCL1/KC显示文摘 | Guerrero AT Cunha TM Verri WA Jr | 2012 | Eur J Pharmacol2012，674，1： | 1 |
| 15 | Immunoregulatory prop- erties of ISG15, an interferon induced cytokine 显示文摘 | D'Cunha J Knight E Jr Haas A L | 1996 | Proc Nail Aead Sci USA1996，93，： | 1 |
| 16 | An electronic pressure-meter nociception paw test for rats显示文摘 | VIVANCOS G G VERRI W A Jr CUNHA T M | 2004 | Braz J Med Biol Res2004，37，3： | 1 |
| 17 | Growth phasedependent subcellular localization of nitric oxide synthase in maize cells 显示文摘 | Ribeiro E A Jr Cunha F Q Tamashiro W M S C et al | 1999 | FEBS Lett1999，445，： | 1 |
| 18 | Immunoregulatory properties of ISG15,an interferon induced cytokine显示文摘 | D'CUNHA J KNIGHT JR E HAAS A L | 1996 | Proc Natl Acad Sci USA1996，93，： | 1 |
| 19 | Growth phasedependent subcellular localization of nitric oxide synthase in maize cells 显示文摘 | Ribeiro E A Jr Cunha F Q Tamashiro W M S C | 1999 | FEBS Lett1999，445，： | 1 |
| 20 | Recombinant migration inhibitory factor induces nitric oxide synthase in murine macrophages 显示文摘 | Cunha FQ Weiser WY David JR | 1993 | J Immunol1993，150，5： | 1 |
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