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| 1 | Chromatoprobe as a sample-sparing technique for residual solvent analysis of drug discovery candidates by gas chromatography显示文摘In drug discovery research, residual solvent measurement is an integral part of purity analysis for synthesis of a drug candidate before it is used for toxicity testing. This is usually carried out using gas chromatography(GC)with direct injection sample introduction. This method requires testing compounds to be soluble at high concentrations( > 50 mg/mL, usually in DMSO) to achieve acceptable sensitivity, a hurdle which is not always achievable for some samples such as cyclic peptides and oligonucleotides. To overcome the limitation associated with the direct injection approach, a new method using the Chromatoprobe thermal extraction device was developed for quantifying residual solvents of drug discovery compounds. This method not only consumes significantly less material(less than 1 mg), but also shows higher sensitivity than the direct injection approach.In addition, because no diluent is required with the Chromatoprobe thermal extraction, all residual solvents can be detected and measured without further method optimization. In our study, we compared data from GC residual solvent analysis using the Chromatoprobe solid sample introduction to those of the direct injection method for seven in-house samples. Our results showed a good agreement between the data from these two sample introduction methods. Thus, the Chromatoprobe sample introduction method provided a samplesparing alternative to the direct injection method for the measurement of residual solvents in drug discovery.This method can be particularly useful for residual solvent analysis in samples that are available only in limited amounts, poorly soluble, and/or unstable in the diluents used for the direct injection method. | Christopher J.Poronsky Jingfang Qian Cutrone | 2017 | Journal of Pharmaceutical Analysis2017，7，4： | 3 |
| 2 | The Class lI cytokine receptor(CRF2)family: overview and patterns of receptor-ligand interactions 显示文摘 | Langer J A Cutrone E C Kotenko S | 2004 | Cytokine g Growth Factor Reviews2004，15，1： | 1 |
| 3 | The class II cytokine receptor(CRF2 ) family: overview and patterns of receptor - ligand inter-actions 显示文摘 | Langer JA Cutrone EC Kotenko S | 2004 | Cytokine Growth Factor Rev2004，15，1： | 1 |
| 4 | Inhibition of the renin-angiotensin system downregulates tissue factor and vascular endothelial growth factor in human breast carcinoma cells 显示文摘 | Emanuela Napoleone Antonella Cutrone Daniela Cugino | 2012 | Thrombosis Research2012，，129： | 1 |
| 5 | Inhibition of the renin-angiotensin system downregulates tissue factor and vascular endothelial growth factor in human breast carcinoma cells显示文摘 | Napoleone E Cutrone A Cugino D | 2012 | Thromb Res2012，129，6： | 1 |
| 6 | Transforming growth factor-b1 in a sterilized tissue derived from the pig small intestine submucosa显示文摘 | McDevitt CA Wildey GM Cutrone RM | 2003 | J Biomed Mater Res A2003，67，： | 1 |
| 7 | Transforming growth factor- beta1 in a sterilized tissue derived from the pig small intestine sub- mucosa 显示文摘 | McDevitt CA Wildey GM Cutrone RM | 2003 | J Biomed Mater Res A2003，67，2： | 1 |
| 8 | Transforming growth factor-beta in a sterilized tissue derived from the pig small intestine submucosa 显示文摘 | McDevitt C A Wildey G M Cutrone R M | 2003 | J Biomed Mater Res2003，67，2： | 1 |
| 9 | Evaluation of acupuncture in the treatment of Parkinson's disease:a double-blind pilot study 显示文摘 | Cristian A Katz M Cutrone E | 2005 | Mov Disord2005，20，9： | 1 |
| 10 | Inhibition of the renin-angiotensin system downregulates tissue factor and vascular endothelial growth factor in human breast carcinoma cells显示文摘 | Napoleone E Cutrone A Cugino D | 2012 | Thrombosis research2012，129，6： | 1 |
| 11 | Transforming growth factor- beta1 in a sterilized tissue derived from the pig small intestine submucosa显示文摘 | McDevitt CA Wildey GM Cutrone RM | 2003 | J Biomed Mater Res A2003，67，2： | 1 |
| 12 | Transforming growth factor-betal in a sterilized tissue derived from the pig small intestine submucosa显示文摘 | McDevitt CA Wildey GM Cutrone RM | 2003 | J Biomed Mater Res A2003，67，2： | 1 |
| 13 | Causal attribution and Perinatm depression 显示文摘 | Cutrone DE | 1983 | J Abnormal Psychology1983，92，： | 1 |
| 14 | The compli- mentary role of diagnostic and therapeutic endoscopy in foreign body aspiration in children显示文摘 | CUTRONE C PEDRUZZI B TAVA G | 2011 | Int J Pediatr Otorhi- nolaryngol2011，75，12： | 1 |
| 15 | Transforming growth factor-beta1 in a sterilized tissue derived from the pig small intestine submucos显示文摘 | McDevitt CA Wildey GM Cutrone RM | 2003 | J Biomed Mater Res A2003，67，63： | 1 |
| 16 | Predictingtransition in two-and three-dimensional separated flows显示文摘 | Cutrone L De Palma P Pascazio G | 2008 | International Journal of Heat and Fluid Flow2008，29，2： | 1 |
| 17 | A RANS flamelet-progress-variable method for computing reacting flows of real-gas mixtures显示文摘 | Cutrone L De Palma P Pascazio G | 2010 | Computers & Fluids2010，39，3： | 1 |
| 18 | Design of a catalytic eombustor for heavy-duty gas turbines 显示文摘 | Touehton G Szema L C Cutrone M B | 1983 | Journal of engineering for power1983，105，： | 1 |
| 19 | Transforming growth factor- beta in a sterilized tissue derived from the pig small intestine submucosa显示文摘 | McDevitt CA Wildey GM Cutrone RM | 2003 | J Biomed Mater Res A2003，67，2： | 1 |
| 20 | The complimentary role of diagnostic And therapeutic endoscopy in foreign body aspiration- in children 显示文摘 | Cutrone C Pedruzzi B Tava G | 2011 | Int J Pediatr Otorhinolaryngol2011，75，12： | 1 |
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