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| 1 | Sitagliptin in patients with non-alcoholic steatohepatitis: A randomized, placebo-controlled trial显示文摘AIM To evaluate the effect of sitagliptin vs placebo on histologic and non-histologic parameters of nonalcoholic steatohepatitis(NASH).METHODS Twelve patients with biopsy-proven NASH were randomized to sitagliptin(100 mg daily)(n=6)or placebo(n=6)for 24 wk.The primary outcome was improvement in liver fibrosis after 24 wk.Secondary outcomes included evaluation of changes in NAFLD activity score(NAS),individual components of NAS(hepatocyte ballooning,lobular inflammation,and steatosis),glycemic control and insulin resistance[including measurements of glycated hemoglobin(Hb A1C)and adipocytokines],lipid profile including free fatty acids,adipose distribution measured using magnetic resonance imaging(MRI),and thrombosis markers(platelet aggregation and plasminogen activator inhibitor 1 levels).We also sought to determine the correlation between changes in hepatic fat fraction(%)[as measured using the Iterative Decomposition of water and fat with Echo Asymmetry and Least-squares estimation(IDEAL)MRI technique]and changes in hepatic steatosis on liver biopsy.RESULTS Sitagliptin was not significantly better than placebo at reducing liver fibrosis score as measured on liver biopsy(mean difference between sitagliptin and placebo arms,0.40,P=0.82).There were no significant improvements evident with the use of sitagliptin vs placebo for the secondary histologic outcomes of NAS total score as well as for the individual components of NAS.Compared to baseline,those patients who received sitagliptin demonstrated improved Hb A1C(6.7%±0.4%vs 7.9%±1.0%,P=0.02),and trended towards improved adiponectin levels(4.7±3.5μg/m L vs 3.9±2.7μg/m L,P=0.06)and triglyceride levels(1.26±0.43 mmol/L vs 2.80±1.64 mmol/L,P=0.08).However,when compared with placebo,sitagliptin did not cause a statistically significant improvement in Hb A1C(mean difference,-0.7%,P=0.19)nor triglyceride levels(mean difference-1.10mmol/L,P=0.19)but did trend towards improved adiponectin levels only(mean difference,0.60μg/m L,P=0.095).No significant changes in anthropometrics,liver enzymes,other adipocytokines,lipid profile,thrombosis parameters,or adipose distribution were demonstrated.The MRI IDEAL procedure correlated well with steatosis scores obtained on liver biopsy in both groups at baseline and post-treatment,and the Spearman correlation coefficients ranged from r=0.819(baseline)to r=0.878(post-treatment),P=0.002.CONCLUSION Sitagliptin does not improve fibrosis score or NAS after 24 wk of therapy.The MRI IDEAL technique may be useful for non-invasive measurement of hepatic steatosis. | Tisha R Joy Charles A McKenzie Rommel G Tirona Kelly Summers Shannon Seney Subrata Chakrabarti Neel Malhotra Melanie D Beaton | 2017 | World Journal of Gastroenterology2017，23，1： | 18 |
| 2 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 3 | Testing for HCV Infection: An Update of Guidance for Clinicians and Laboratorians显示文摘 | Getchell Jane P Wroblewski Kelly E DeMaria Alfred Bean Christine L Parker Monica M Pandori Mark Dufour D Robert Busch Michael P Brecher Mark E Meyer William A Pesano Rick L Teo Chong-Gee Beckett Geoffrey A Araujo Aufra C Branson Bernard M D | 2013 | MMWR. Morbidity and Mortality Weekly Report2013，，18： | 3 |
| 4 | Human disease modeling with induced pluripotent stem cells显示文摘 | Alan Trounson Kelly A Shepard Natalie D DeWitt | 2012 | Current Opinion in Genetics & Development2012，，5： | 2 |
| 5 | Correlation between bovine milksomatic cell count and polymorphonuclear leukocyte level for samples of bulkmilk and milk from individual cows显示文摘 | Kelly A L Tiernan D O'Sullivan C | 2000 | Journal of Dairy Science2000，83，2： | 1 |
| 6 | Angiotensin type 2 receptor is expressed in the adult rat kidney and promotes cellular proliferation and apoptosis 显示文摘 | Cao Z Kelly D J Cox A | 2000 | Kidney Int2000，58，6： | 1 |
| 7 | Dietary fatty acid sources affect conjugated linoleic acid concentrations in milk from lactating dairy cows显示文摘 | Kelly M L Berry D A Dwyer J M | 1998 | J Nutr1998，128，： | 1 |
| 8 | Tourniquet safety in lower leg applications显示文摘 | MCEWEN J A KELLY D L JARDANOWSKI T | 2002 | Orthop Nurs2002，21，5： | 1 |
| 9 | An evaluation of failure criteria for ma- trix induced failure in composite materials显示文摘 | Li R Kelly D Crosky A | 2002 | Composite Struc- tures2002，57，1： | 1 |
| 10 | Evaluation of approaches for determining design allowables for bolted joints in laminated composites显示文摘 | WANG J BANBURY A KELLY D W | 1998 | Composite Structures1998，41，： | 1 |
| 11 | Robust analysis of the yeast proteome under 50 kDa by molecular-massbased fractionation and top-down mass spectrometry显示文摘 | Kellie J F Catherman A D Durbin K R Tran J C Tipton J D Norris J L Witkowski C E 2nd Thomas P M Kelleher N L | | 0，，01： | 1 |
| 12 | Rate control in communication networks:shadow prices,proportional fairness and stability显示文摘 | KELLY F P MAULLOO A TAN D | 1998 | Journal of the Operational Research Society1998，49，3： | 1 |
| 13 | Rate Control for Communication Networks:Shadow Prices,Proportional Fairness and Stability显示文摘 | Kelly F P Maulloo A Tan D | 1998 | Journal of Operations Research Society1998，49，3： | 1 |
| 14 | Activities and postantibiotic effects of gemifloxacin compared to those of 11 other agents against Haemophilus influenzae and Moraxella catarrhalis显示文摘 | Davies T A Kelly L M Hoellman D B | 2000 | Antimicrob Agents Chemother2000，44，3： | 1 |
| 15 | The application of infrared mieroimaging for the determination of the distribution, penetration depth,and diffusion profile of methyl centralite and dibutyl phthalate deterrents in nitrocellulose monoperforated propellant 显示文摘 | Louden J D Duncan I A Kelly J | 1993 | Journal of Applied Polymer Science1993，49，： | 1 |
| 16 | Standards for nutrition support: home care patients 显示文摘 | Kovacevich DS Frederick A Kelly D | 2005 | Nutr Clin Pract2005，20，5： | 1 |
| 17 | 查看详情显示文摘 | Regan S P Marozas J A Craxton R S Kelly J H Donaldson W R Jaanimagi P A Jacobs-Perkins D Keck R L Kessler T J Mey-erhofer D D Sangster T C Seka W Smalyuk V A Sknpsky S Zuegel J D | | 0，，： | 1 |
| 18 | The Impact of Food Prices on Consumption: A Systematic Review of Research on the Price Elasticity of Demand for Food显示文摘 | TATIANA A Michael W L KELLY D B | 2010 | American Journal of Public Health2010，100，2： | 1 |
| 19 | OMEGA EP high-energy petawatt laser: progress and prospects显示文摘 | D N Maywar J H Kelly L J Waxer S F B Morse I A Begishev J Bromage C Dorrer J L Edwards L Folnsbee M J Guardalben S D Jacobs R Jungquist T J Kessler R W Kidder B E Kruschwitz S J Loucks J R Marciante R L McCrory D D Meyerhofer A V Okishev J B Oliver G Pien | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 20 | The effect of fermented liquid feeding on the faecal microbiology and colostrum quality of farrowing sows 显示文摘 | Demeckova V Kelly D Coutts A G P | 2002 | International Food Microbiology2002，79，： | 1 |
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