|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Differential colorectal carcinogenesis:Molecular basis and clinical relevance显示文摘Colorectal cancer(CCR) is one of the most frequent cancers in developed countries.It poses a major public health problem and there is renewed interest in understanding the basic principles of the molecular biology of colorectal cancer.It has been established that sporadic CCRs can arise from at least two different carcinogenic pathways.The traditional pathway,also called the suppressor or chromosomal instability pathway,follows the Fearon and Vogelstein model and shows mutation in classical oncogenes and tumour suppressor genes,such as K-ras,adenomatous polyposis coli,deleted in colorectal cancer,or p53.Alterations in the Wnt pathway are also very common in this type of tumour.The second main colorectal carcinogenesis pathway is the mutator pathway.This pathway is present in nearly 15% of all cases of sporadic colorectal cancer.It is characterized by the presence of mutations in the microsatellite sequences caused by a defect in the DNA mismatch repair genes,mostly in hMLH1 or hMSH2.These two pathways have clear molecular differences,which will be reviewed in this article,but they also present distinct histopathological features.More strikingly,their clinical behaviours are completely different,having the 'mutator' tumours a better outcome than the 'suppressor' tumours. | Alberto Morán Paloma Ortega Carmen de Juan Tamara Fernández-Marcelo Cristina Frías Andrés Sánchez-Pernaute Antonio José Torres Eduardo Díaz-Rubio Pilar Iniesta Manuel Benito | 2010 | World Journal of Gastrointestinal Oncology2010，2，3： | 5 |
| 2 | Reported tailings dam failures显示文摘 | M. Rico G. Benito A.R. Salgueiro A. Díez-Herrero H.G. Pereira | 2007 | Journal of Hazardous Materials2007，，2： | 2 |
| 3 | Effects of naloxone on opioid-induced hyperalgesia and tolerance to remifentanil under sevoflurane anesthesia in rats 显示文摘 | AGUADO D ABREU M BENITO J | 2013 | Anesthesiology2013，118，5： | 1 |
| 4 | Determination of quinolones in water samples by solid - phase extraction and liquid chromatography with fluorimetric detection 显示文摘 | Prat M D Benito J Compafi6 R | 2004 | J Chromatogr A2004，1041，1： | 1 |
| 5 | Erythropoietin can promote ery- throid progenitor survival by repressing apoptosis through Bcl-XL and Bcl-2 显示文摘 | Silva M Grillot D Benito A | 1996 | Blood1996，88，5： | 1 |
| 6 | Balloon angioplasty for native coarctation in children:immediate and medium-term results显示文摘 | Cerro D Aurora FR Benito F | 2005 | Rev Esp Cardiol2005，58，： | 1 |
| 7 | High-resolution meas- urement of stimulated Brillouin scattering spectra in sin- gle-mode fibres 显示文摘 | Loayssa A Benito D Garde M J | 2001 | lEE Proceedings-Optoelectronics2001，148，3： | 1 |
| 8 | Effects of naloxone on opioid-induced hyperalgesia and tolerance to remifentanil under sevoflurane anesthesia in rats显示文摘 | Aguado D Abreu M Benito J | 2013 | Anesthesiology2013，118，5： | 1 |
| 9 | Erythropoietin can promote erythroid progenitor survival by repressing apoptosis through Bcl-XL and Bcl-2 显示文摘 | Silva M Grillot D Benito A | 1996 | Blood1996，88，： | 1 |
| 10 | Use of pruning waste compost as a component in soilless growing media显示文摘 | Benito M Masaguer A Antonio R D | 2005 | Bioresource Technology2005，96，： | 1 |
| 11 | Characterization of excretory-secretory products from protoscoleces of Echinococcus granulosus and evaluation of their potential for immunodiagnosis of human cystic echinococcosis显示文摘 | Carmena D Martinez J Benito A | 2004 | Parasitology2004，129，3： | 1 |
| 12 | Erythropoietin can promote erythroidprogenitor survival by repressing apoptosis through Bcl-XL and Bcl-2显示文摘 | Grillot D Benito A | 1996 | Blood1996，88，5： | 1 |
| 13 | Indications for epiphyseal preservation in metphyseal malignant bone tumors of children: Relationship between image methods and histological findings显示文摘 | San-Julian M Aquerreta J D Benito A | 1999 | J Pediatr Orthop1999，19，4： | 1 |
| 14 | Combustion study of partially gasified willow and DDGS chars using TG analysis and COMSOL modeling 显示文摘 | MENG Xiang-mei JONG W D BADRI F S BENITO P BASILE F VERKOOIJEN A H M | 2012 | Biomass and Bioenergy2012，39，： | 1 |
| 15 | Synovial tissue inflammation in early and late osteoarthritis显示文摘 | Benito M J Veale D J Fitzgerald O | 2005 | Ann Rheum Dis2005，64，9： | 1 |
| 16 | Erythropoietin can promote erythroid progenitor survival by repressing apoptosis through Bcl-xL and Bcl-2显示文摘 | Silva M Grillot D Benito A | 1996 | Blood1996，88，5： | 1 |
| 17 | Apoptosis induced by erythroid differentiation of human leukemia cell line is inhibited by bcl-xl显示文摘 | Benito A Silva M Grillot D | 1996 | Blood1996，87，9： | 1 |
| 18 | Applications of optical carrier Brillouin processing to microwave photonics显示文摘 | LOAYSSA A BENITO D GARDE M | 2002 | Optical Fiber Technology2002，8，1： | 1 |
| 19 | Effects of naloxone on opioid- induced hyperalgesia and tolerance to remifentanil under sevoflurane anesthesia in rats显示文摘 | Aguado D Abreu M Benito J | 2013 | Anesthesiology2013，118，5： | 1 |
| 20 | Results of applying a universal protocol for early detection of hypoacusia in newborn infants for 42months显示文摘 | Benito Orejas JI Ramírez Cano B Morais Pérez D | 2008 | Acta Otorrinolaringologica(English Edition)2008，59，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员