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| 1 | Magnetic resonance imaging of hepatocellular carcinoma induced by diethylnitrosamine in Sprague-Dawley rats显示文摘Diethylnitrosamine (DENA) is able to induce various benign and malignant liver lesions in rats with a high success rate and a low mortality rate. It provides a more appropriate model that better simulates the various lesions occurring in humans than the usual model of tumor implantations. The aim of the present study was to evaluate MRI liver examination in Sprague-Dawley(SD) rats as a routine method to detect hepatocellular carcinoma (HCC) nodules induced by DENA and to follow up their growth. METHODS:Hepatic carcinogenesis was induced in 80 male SD rats using oral DENA solution. All animals were imaged for liver tumor detection with a 1.5 Tesla magnet (Siemens Sonata,Erlangen, Germany) using correspondence scan parameters and a radio-frequency knee coil. Macroscopic examinations were performed along the axial MRI sections to evaluate magnetic resonance imaging (MRI) findings, and histopathological assessment was also performed. RESULTS:No false negative results were obtained on MR images. Hepatic tumors in 72 rats were confirmed macro-scopically and 68 rats were detected by MRI till the 20th week. The smallest and the largest nodules detected by MRI were 2 mm and 37 mm in diameter respectively. The agreement rate of MRI with macroscopic observation was 39. 1% and 97. 4% respectively for 2 mm to 5 mm and more than 5 mm nodules. CONCLUSIONS:The hepatic tumor induced by DENA provides a more representative range of tumors for imaging diagnosis and interventional treatment. MRI is the best approach for scrutinizing pathological changes of rat livers in the period of observation. | Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China (Li X, Zhou XP and Guan YS) Department of Radiology, Ruijin Hospieal. Shanghai Second Medical University, Shanghai 200025 , China. Current address:Astra Zeneca R & D Alderley, Macclesfield SK 10 4 TG U. K. (Wang YX) | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 3 |
| 2 | Quantitative analysis of Boehm' s GC显示文摘The term garbage collection describes the automated process of finding previously allocated memorythatis no longer in use in order to make the memory available to satisfy subsequent allocation requests. Wehave reviewed existing papers and implementations of GC, and especially analyzed Boehm' s C codes, which isa real-time mark-sweep GC running under Linux and ANSI C standard. In this paper, we will quantitatively an-alyze the performance of different configurations of Boehm' s collector subjected to different workloads. Reportedmeasurements demonstrate that a refined garbage collector is a viable alternative to traditional explicit memorymanagement techniques, even for low-level languages. It is more a trade-off for certain system than an all-or-nothing proposition. | GUAN Xue-tao~*, ZHANG Yuan-rui, GOU Xiao-gang, CHENG Xu (MicroProcessor R & D Center, Peking University, Beijing 100871, China, | 2003 | Journal of Harbin Institute of Technology(New Series)2003，10，3： | 2 |
| 3 | 查看详情显示文摘 | Peng X G Guan S Q Chai X D | | 0，，： | 2 |
| 4 | Rough computational methods for information systems 显示文摘 | Guan J W Bell D A | 1998 | Artificial Intelligences1998，105，12： | 2 |
| 5 | Examination of the indentation size effect in low-load vickers hardness testing of ceramics显示文摘 | GONG J H WU J J GUAN Z D | 1999 | Journal of the European Ceramic Society1999，19，15： | 1 |
| 6 | Expression of HIF-lalpha and VEGF in colorectal cancer: association with clinical outcomes and prognostic implieations显示文摘 | Cao D Hou M Guan YS | 2009 | BMC Cancer2009，9，： | 1 |
| 7 | A wind-tunnel study of windbreakdrag显示文摘 | GUAN D ZHANG Y ZHU T | 2003 | Agriculture and Forest Meteorology2003，118，： | 1 |
| 8 | Modeling and dynamic assessment of urban economy -resource -environment system with a coupled system dynamics-geographic information system model显示文摘 | Guan D J | 2006 | Ecological Indicators2006，11，5： | 1 |
| 9 | Association of TGF-betalgenetic variants with HPV16-positive oropharyngeal cancer显示文摘 | Guan X Sturgis EM Lei D | 2010 | Clin Cancer Res2010，16，5： | 1 |
| 10 | Chronic hepatitis Bvirus infection in Asian countries显示文摘 | Schroter I Guan R Amarapuka D | 2000 | J Gastroenterol Hepatol2000，15，12： | 1 |
| 11 | Effect of Aging at 700 'C on Precipitation and Toughness of AISI 321 and AISI 317 Austenitic Stainless Steel Welds 显示文摘 | Guan K S Xu X D Xu H | 2005 | Nuclear Engineering and Design2005，235，23： | 1 |
| 12 | Preparation and electrochemical properties of AI/Pb-PANI-WC composite inert anodes 显示文摘 | XU R D GUAN Y Y CHEN H S | 2013 | Journal of the Chinese Advanced Materials Society2013，1，1： | 1 |
| 13 | Rapid gastric emptying of a solid pancake meal in type II diabetic patients 显示文摘 | Schwartz JG Green GM Guan D | 1996 | Diabetes Care1996，19，5： | 1 |
| 14 | Long-time observation of annual variation of Taiwan Strait upwelling in summer season显示文摘 | Tang D L Kawamura H Guan L | | 0，，3： | 1 |
| 15 | BRAF mutation testing of thyroid fine-needle aspiration biopsy specimens for preoperative risk stratification in papillary thyroid cancer 显示文摘 | Xing M Clark D Guan H | 2009 | J Clin Oncol2009，27，18： | 1 |
| 16 | Critical roles of p53 in epithelial-mesenchymal transition and metastasis of hepatocellular carcinomacells显示文摘 | Wang Z Jiang Y Guan D | 2014 | PLoS One2014，8，72： | 1 |
| 17 | Sensitivity analysis of brake squeal tendency to substructures' modal parameters 显示文摘 | GUAN D H SU X D ZHANG F | 2006 | Journal of Sound and Vibration2006，291，12： | 1 |
| 18 | Growth hormone receptor is a target for presenilin-dependent gam- ma-secretase cleavage 显示文摘 | Cowan J W Wang X D Guan R He K Jiang J Baumann G Black R A Wolfe M S Frank S J | 2005 | J Biol Chem2005，280，19： | 1 |
| 19 | Highly Selective Aerobic Oxidation of Alcohol Catalyzed by a Gold( I ) Complex with an Anionic Ligand显示文摘 | Guan B Xing D Cai G | 2005 | J Am Chem Soc2005，127，18： | 1 |
| 20 | Vibration and audible noise of capacitors subjected to non-sinusoidal waveforms显示文摘 | Cox M D Guan H H | 1994 | IEEE Transactions on Power Delivery1994，9，2： | 1 |
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