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| 1 | Coordinated peak expression of MMP-26 and TIMP-4 in preinvasive human prostate tumor显示文摘因为早察觉和治疗为病人的医药管理是批评的,为早前列腺癌症诊断的新奇简历标记的鉴定是高度重要的。在基础房间层和地下室膜的连续性的混乱为高级职业人员静电干扰 intraepithelial 瘤形成(HGPIN ) 的前进是必要的到在人的前列腺的侵略腺癌。涉及变换到侵略显型的分子是强烈审查的题目。我们以前报导了矩阵 metalloproteinase-26 (MMP-26 ) 经由地下室膜蛋白质并且由激活 MMP-9 的酶原形式的劈开支持人的前列腺癌症房间的侵略。而且,我们发现了 metalloproteinases-4 (TIMP-4 ) 的那个织物禁止者是大多数有势力 MMP-26 的内长的禁止者。这里,我们更高示威(p<0.0001 ) 在 HGPIN 和癌症的 MMP-26 和 TIMP-4 表示,与非肿瘤的 acini 相比。他们的表示层次在 HGPIN 是最高的,但是在一样的纸巾在侵略癌症(为各个的 p<0.001 ) 衰退。连续前列腺癌症织物节染色的 Immunohistochemical 建议 MMP-26 和 TIMP-4 的 colocalization。现在的学习显示 MMP-26 和 TIMP-4 可以在 HGPIN 的变换期间起一个不可分的作用到侵略癌症并且可以也为早前列腺癌症诊断用作标记。房间研究(2006 ) 16:750-758。做 i:10.1038/sj .cr.7310089;出版联机 2006 年 8 月 29 日。 | Seakwoo Lee Kevin K Desai Kenneth A Iczkowski Robert G Newcomer Kevin J WU Yun-Ge Zhao Winston W Tan Mark D Roycik Qing-Xiang Amy Sang | 2006 | Cell Research2006，16，9： | 18 |
| 2 | 肌萎缩性侧索硬化蛋白激活小胶质细胞NLRP3炎性小体显示文摘小胶质细胞NLRP3炎性小体激活正在成为神经退行性变过程中神经炎症的关键因素。诸如β-淀粉样蛋白和α-突触核蛋白之类的致病性蛋白质聚集体触发小胶质NLRP3激活,从而导致半胱天冬酶-1激活和IL-1β的分泌。在小鼠肌萎缩性侧索硬化症(ALS)的SOD1G93A模型中,半胱天冬酶-1和IL-1β均促进疾病进展,提示小胶质NLRP3在该进程中发挥作用。然而先前的研究表明,SOD1G93A小鼠小胶质细胞不表达NLRP3,SOD1G93A蛋白在小胶质细胞中产生独立于NLRP3的IL-1β。本研究论证了使用Nlrp3-GFP基因敲入小鼠,在SOD1G93A小鼠中小胶质细胞表达NLRP3。本研究显示聚集和可溶性SOD1G93A均可激活小鼠原代小胶质细胞中的炎性小体,导致半胱天冬酶-1和IL-1β裂解,ASC斑点形成以及呈剂量和时间依赖性的IL-1β分泌。重要的是,SOD1G93A无法从缺乏Nlrp3的小胶质细胞或者用特异性NLRP3抑制剂MCC950预处理的小胶质细胞中诱导IL-1β分泌,从而证实NLRP3是介导SOD1诱导的小胶质细胞IL-1β分泌的关键炎症小体复合物。在TDP-43Q331K ALS小鼠模型中也观察到小胶质NLRP3上调,TDP-43野生型和突变蛋白亦可以NLRP3依赖性的方式激活小胶质炎性小体。从机制上讲,本研究确定了活性氧簇和ATP的生成是SOD1G93A介导的NLRP3激活所需的关键事件。总之,本研究的数据表明ALS小胶质细胞表达NLRP3,而病理ALS蛋白激活小胶质NLRP3炎性小体。因此,NLRP3抑制可能是阻止小胶质细胞神经炎症和ALS疾病进展的潜在治疗方法。 | Vandana Deora John D Lee Eduardo AAlbornoz Luke McAlary Cyril J Jagaraj Avril A B Robertson Julie D Atkin Matthew A Cooper Kate Schroder Justin J Yerbury Richard Gordon Trent MWoodruff 杜一星(编译) | 2020 | 神经损伤与功能重建2020，15，9： | 13 |
| 3 | 肠道菌群衍生的短链脂肪酸促进老年小鼠的脑卒中后恢复显示文摘老年人在脑卒中后经历了严重的全身反应,这导致了更高的死亡率和更严重的长期残疾。最近的研究表明,肠道微生物群的组成可以影响脑卒中的预后。然而,在损伤后肠道微生物群对预后影响的潜在益处尚不清楚。为了确定脑卒中后年轻肠道微生物是否有助于老年受试者的康复,研究者通过年轻粪便移植灌胃(young fecal transplant gavage,young FTG)改变了实验性脑卒中后老年小鼠的肠道微生物群。 | 刘青(译) 刘莉(摘/审校) Lee J d’Aigle J Atadja L | 2020 | 中华高血压杂志2020，28，6： | 12 |
| 4 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 5 | Fabrication of SAW Sensor for Detecting Chemical Agent显示文摘SAW sensors using five different types of polymer to detect of chemical agents(DMMP,CH_3CN,CH_2Cl_2,DCP) have been fabricated and its gas response characteristics were extensively investigated.The polymers used as the sensing material are polyisobutylene(PIB),polyepichlorohydrin(PECH),polydimethylsiloxane(PDMS),polyisoprene(PIP)and polybutadiene(PBD).Their thin films were coated on quartz substrate by spin coating technique.Three types of simulants gases,dimethylmethylphosphonate(DMMP),acetonitrile(CH_3CN)and dichloromethane(CH_2Cl_2),dichloropentane(DCP)were used as target gases,instead of the real nerve,blood,choking and vesicant agents.After spin coating of PIB and PECH,the substrates were heated to 65℃with N_2 flow for 1 h to remove the cyclohexane and ethylacetate which was used as solvent. PDMS was heated to 75℃with N_2 flow for 2 h to remove the ethylacetate which was used as solvent.PBD and PIP on the substrate were heated to 60℃with N_2 flow for 1 h to remove the benzen which was used as solvent.The sensing characteristics of the SAW sensors were measured by using E-5061A network analyzer. | J H Lee B S Joo J S Huh D D Lee | 2006 | 稀有金属材料与工程2006，35，A03： | 3 |
| 6 | Fault detection method with PCA and LDA and its application to induction motor显示文摘A feature extraction and fusion algorithm was constructed by combining principal component analysis(PCA) and linear discriminant analysis(LDA) to detect a fault state of the induction motor.After yielding a feature vector with PCA and LDA from current signal that was measured by an experiment,the reference data were used to produce matching values.In a diagnostic step,two matching values that were obtained by PCA and LDA,respectively,were combined by probability model,and a faulted signal was finally diagnosed.As the proposed diagnosis algorithm brings only merits of PCA and LDA into relief,it shows excellent performance under the noisy environment.The simulation was executed under various noisy conditions in order to demonstrate the suitability of the proposed algorithm and showed more excellent performance than the case just using conventional PCA or LDA. | JUNG D Y LEE S M 王洪梅 KIM J H LEE S H | 2010 | Journal of Central South University2010，17，6： | 3 |
| 7 | Microchimerism in recurrent miscarriage显示文摘在怀孕期间,在 microchimerism 的获得的结果,它经久地装在两个接受者坚持的母亲胎儿的房间交换。自然地获得的 microchimerism 可以在怀孕影响母亲胎儿的相互作用。我们进行了研究问一个女人从她的自己的母亲获得了的 microchimerism 是否是可检测的在前或在在有周期性的流产的女人的怀孕期间。胎儿的 microchimerism 也是 assayed。有主要自发的周期性的流产的女人(n= 23 ) 并且控制(n= 31 ) 被学习。Genotyping 为 probands,他们的母亲和胎儿,被进行识别的非分享的多型性和量的聚合酶链反应表现了测量 microchimerismin 外设血 mononuclear 房间。预想比较在周期性的流产题目和控制之间被做,用逻辑回归和 Wilcoxon 等级和。在周期性的流产题目的随后的怀孕的纵的 microchimerism 被描述。向在周期性的流产对控制的 microchimerism 的更低的预想察觉有一个趋势, 6 %对 19 %(1/16 对 6/31, P= 0.2 ) 。在怀孕期间, 3/11 (27 %) 继续了有的周期性的流产题目,出生从他们的自己的母亲有 microchimerism 的察觉,而任何一个继续了流产的二个题目都没有察觉(0/2 ) 。这个起始的数据当可检测时,与周期性的流产在女人从一个女人的自己的母亲建议那 microchimerism,可以不同于控制并且根据随后的怀孕结果。进一步的研究被需要在周期性的流产决定房间类型,数量和 microchimerism 的任何潜在的功能的角色。 | Hilary S Gammill Mary D Stephenson Tessa M Aydelotte J Lee Nelson | 2014 | Cellular & Molecular Immunology2014，11，6： | 2 |
| 8 | Fault diagnosis and temperature sensor recovery for an air-handling unit显示文摘 | LEE W Y HOUSE J M SHIN D R | 1997 | ASHRAE Transactions1997，，： | 2 |
| 9 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 10 | A study on a platinum-silicon carbide Schottky diodes as a hydrogen gas sensor 显示文摘 | Kim C K Lee J H Lee Y H Cho N I and Kim D J | 2000 | Sensors and Actuators B2000，66，： | 2 |
| 11 | Large-strain elastic-plastic finite element analysis of rolling process显示文摘 | Lee J D | 1998 | Computer Method in Applied Mechanics and Engineering1998，161，34： | 2 |
| 12 | A prospective feasibility study of sub-millisievert abdominopelvic CT using iterative reconstruction in Crohn’s disease显示文摘 | Siobhan B O’Neill Patrick D Mc Laughlin Lee Crush Owen J O’Connor Sebastian R Mc Williams Orla Craig Anne Marie Mc Garrigle Fiona O’Neill Jackie Bye Max F. Ryan Fergus Shanahan Michael M Maher | 2013 | European Radiology2013，，： | 2 |
| 13 | Two algorithms for constructing a delaunay triangulation显示文摘 | Lee D T Schacheer B J | 1980 | International Journal of Computer and Information Science1980，9，1： | 2 |
| 14 | Characteristics of nitrile--butadiene rubber layered silicate nanocomposites with silane coupling agent 显示文摘 | Kim J T Lee D Y Oh T S | 2003 | J Appl Polym Sci2003，89，10： | 1 |
| 15 | lntra-Task Voltage Scheduling for Low-Energy Hard Real-Time Applieations显示文摘 | Shin D Kim J Lee S | 2001 | IEEE Design and Test of Computers2001，18，2： | 1 |
| 16 | Formation of ultrafine ferrite by strain- induced dynamic transformation in plain low carbon steel 显示文摘 | Choi J K Seo D H Lee J S | 2003 | ISIJ International2003，43，5： | 1 |
| 17 | Effect of dietary essential fatty acids on growth, body composition and blood chemistry of juvenile starry flounder Platichthys stellatus 显示文摘 | Lee S M Lee J H Kim K D | 2003 | Aquaculture2003，225，： | 1 |
| 18 | Optimal Joint Pricing and Lot Sizing with Fixed and Variable Capacity显示文摘 | KIM D S LEE W J | 1998 | European Journal of Operational Research1998，109，1： | 1 |
| 19 | Power electronics technology at the dawn of the new millennium-status and future 显示文摘 | Lee F C | 1999 | Proceedings of IEEE PESC1999，，： | 1 |
| 20 | Correlation of microstructure with dynamic deformation behavior and penetration performance of tungsten heavy alloys fabricated by mechanical alloying显示文摘 | LEE S RYU H J | 2000 | Metall and Mater Trans A2000，31，： | 1 |
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