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| 1 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 2 | Soil physical quality of aBrazilian Oxisol under two tillage systems using the least limiting waterrange approach显示文摘 | TORMENA C A DA SILVA A P LIBARDI P L | 1999 | Soil&Tillage Research1999，52，： | 1 |
| 3 | Parametric Study of Adhesive Joints with Composites 显示文摘 | NETO J A B P CAMPILHO R D S G DA SILVA L F M | 2012 | International Journal of Adhesion and Adhesives2012，，： | 1 |
| 4 | Analytical models of adhesively bonded joints-Part I:literature survey显示文摘 | da Silva L F M das Neves P J C Adams R D | 2009 | International Journal of Adhesion and Adhesives2009，29，3： | 1 |
| 5 | Experimental assessment of perfobond and T- perfobond shear connectors' structural response 显示文摘 | Vianna J da C Costa-Neves L F da S Vellasco P C G | 2008 | Journal of Constructional Steel Research2008，65，2： | 1 |
| 6 | Comprehensive two-dimensional gas chromatography/mass spectrometric analysis of pepper voatiles显示文摘 | Cardeal Z L Gomes da Silva M D Marriott P J | 2006 | Rapid Commun Mass Spectrom2006，20，： | 1 |
| 7 | The impedance of stainless-steel electrodes显示文摘 | Geddes L A Da Costa C P Wise G | 1971 | Medical & Biological Engineering1971，9，5： | 1 |
| 8 | Active learning paradigms for CBIR systems based on optimum-path forest classification 显示文摘 | da SILVA A T FALC?O A X MAGALH?ES L P | 2011 | Pattern Recognition2011，44，12： | 1 |
| 9 | Structural behaviour of T-perfobond shear connectors in composite girders: An experimental approach显示文摘 | Vianna J da C Costa-Neves L F da S Vellasco P C G | 2008 | Engineering Structures2008，30，9： | 1 |
| 10 | Radiographics Pattern Recognition of Welding Defects Using Linear Classifiers显示文摘 | R R da Silva M H S Siqueira L P Caloba etc | 2001 | Insight2001，，10： | 1 |
| 11 | Small- disturbance voltage stability of distribution systems with induction generators显示文摘 | Freitas ~ da Silva L C P Morelato A | 2005 | IEEE Transactions on Power Systems2005，20，3： | 1 |
| 12 | Relation- ship between endotoxin and prostaglandin(PGE2 and PGFM) concent rations and ovarian function in dairy cows with puerperal endometritis显示文摘 | Mateus L Lopes da Costa L Diniz P | 2003 | Anim Reprod Sci2003，76，34： | 1 |
| 13 | Total, insoluble and soluble dietary fiber values measured by enzymatic-gravimetric method in cereal grains 显示文摘 | Da SILVA L P CIOCCAM de L S | 2005 | Journal of Food Composition and Anlysis2005，18，1： | 1 |
| 14 | Solution structure of termicin,an antimicrobial peptide from the termite Pseudacanthotermes spiniger显示文摘 | Da Silva P Jouvensal L Lamberty M | 2003 | Protein Sci2003，12，3： | 1 |
| 15 | A systems ap- proach for the estimation of the effects of land consolidation project (LCPs): a model and its application 显示文摘 | Castro Colho J Aguiar Pinto P Mira da Silva L | 2001 | Agricultural System2001，68，： | 1 |
| 16 | ICP OES simultaneous determination of Ca, Cu, Fe, Mg, Mn, Na, and P inbiodiesel by axial and radial inductively coupled plasma-optical emission spectrometry显示文摘 | de SOUZA R M LEOCADIO L G da SILVEIRA C L P | 2008 | Analytical Letter2008，41，9： | 1 |
| 17 | The nonsubsampled contourlet transform: theory, design, and applications 显示文摘 | Da Cunha A L Zhou J P Do M N | 2006 | IEEE Transactions on Image Processing(S1057-7149)2006，15，10： | 1 |
| 18 | Support vector machines for transient stability analysis of large-scale power systems显示文摘 | Moulin L S Alves da Silva A P El-Sharkawi M A | 2004 | IEEE Transactions on Power Systems2004，19，2： | 1 |
| 19 | A new contingency analysis approach for voltagecollapse assessment显示文摘 | de SOUZAA A C Z da SILVAA A P A JARDIMB J L A | 2003 | Electrical Power and Energy Systems2003，25，10： | 1 |
| 20 | Parameterized fast deeoupled power flow methods for obtaining the maximum loading point of power systems Part Ⅰ and Part Ⅱ显示文摘 | Alves D A Da Silva L C P Castro C A | 2004 | Electric Power Systems Research2004，69，： | 1 |
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