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| 1 | Evaluation of quantitative contrast harmonic imaging to assess malignancy of liver tumors:A prospective controlled two-center study显示文摘AIM: To establish the extent to which contrast enhancement with SonoVue in combination with quantitative evaluation of contrast-medium dynamics facilitates the detection of hepatic tumors. METHODS: One hundred patients with histologically confirmed malignant or benign hepatic tumor (maximum size 5 cm) were analyzed. Contrast-enhanced ultrasound (bolus injection 2.5 mL SonoVue) was carried out with intermittent breath-holding technique using a multifrequency transducer (2.5-4 MHz). Native vascularization was analyzed with power Doppler. The contrast-enhanced dynamic ultrasound investigation was carried out with contrast harmonic imaging in true detection mode during the arterial,portal venous and late phases. Mechanical index was set at 0.15. Perfusion analysis was performed by post-processing of the raw data time intensity curve (TIC) analysis. The cut-off of the gray value differences between tumor and normal liver tissue was established using Receiver Operating Characteristic (ROC) analysis 64-line multi-slice computed tomography served as reference method in all cases. Magnetic resonance tomography was used additionally in 19 cases. RESULTS: One hundred patients with 59 malignant (43 colon,5 breast,2 endocrine metastases,7 hepatocellular carcinomas and 2 kidney cancers) and 41 benign (15 hemangiomas,7 focal nodular hyperplasias,5 complicated cysts,2 abscesses and 12 circumscribed fatty changes) tumors were included. The late venous phase proved to be the most sensitive for classification of the tumor type. Fifty-eight of the 59 malignant tumors were classified as true positive,and one as false negative. This resulted in a sensitivity of 98.3%. Of the 41 benign tumors,37 were classified as true negative and 4 as false negative,which corresponds to a specificity of 90.2%. Altogether,95.0% of the diagnoses were classified as correct on the basis of the histological classification. No investigator-dependency (P = 0.23) was noted. CONCLUSION: The results show the possibility of accurate prediction of malignancy of hepatic tumors with a positive prognostic value of 93.5% using advanced contrast-enhanced ultrasound. Contrast enhancement with SonoVue in combination with quantitative evaluation of contrast-medium dynamics is a valuable tool to discriminate hepatic tumors. | EM Jung DA Clevert AG Schreyer S Schmitt J Rennert R Kubale S Feuerbach F Jung | 2007 | World Journal of Gastroenterology2007，13，47： | 15 |
| 2 | Anti-estrogen stimulate human endometrial cancer growth:laboratory and clinical consideration显示文摘 | Tonetti DA O Regan R Tanjore S | 1998 | J Steroid Biochem Mol Biol1998，65，： | 1 |
| 3 | Parametric Study of Adhesive Joints with Composites 显示文摘 | NETO J A B P CAMPILHO R D S G DA SILVA L F M | 2012 | International Journal of Adhesion and Adhesives2012，，： | 1 |
| 4 | Prediction of core saturation instability at an HVDC converter显示文摘 | Burton R S Fuchshuber C Woodford DA | 1996 | IEEE Trans on Power Delivery1996，11，4： | 1 |
| 5 | Prediction of rain attenuation in terrestrial links using full rainfall rate distribution显示文摘 | SILLVA MELLO DA L A R PONTES M S SOUZA DE R M | 2007 | Electronics Letters2007，43，25： | 1 |
| 6 | Enthalpies of combustion, vapour pressures, and enthalpies of sublimation of 8- hydroxyquinoline, 5-nitro-8-hydroxyquinoline, and 2-methyl-8-hydroxyquinoline显示文摘 | Ribeiro Da Silva M A V Monte M J S Matos M A R | 1989 | Chem Thermodyn1989，，21： | 1 |
| 7 | The Mycobacterium tuberculosis protein serine/threonine kinase PknG is linked to cellular glutamate/glutamine levels and is important for growth in vivo显示文摘 | Cowley S Ko M Pick N Chow R Downing KJ Gordhan BG Betts JC Mizrahi V Smith DA Stokes RW Av-Gay Y | 2004 | Mol Microbiol2004，52，6： | 1 |
| 8 | Inhibitory action of aqueous coffee ground extracts on the corrosion of carbon steel in HC1 solution 显示文摘 | TORRESS V V AMADO R S de sAC F FERNANDEZ T L da SILVA RIEHI C A TORRES A G D'ELIA E | 2011 | Corrosion Science2011，53，： | 1 |
| 9 | Immune system and immune responses in fish and their role in com- parative immunity study: a model for higher organisms 显示文摘 | RAUTA P R NAYAK B DA S S | 2012 | Immunology Letters2012，148，1： | 1 |
| 10 | Molecular differenc- es between hydrocarbon and fluorocarbon surfaetants at the COJ water interface 显示文摘 | Stone M T Da Rocha S R P Rossky P J | 2003 | Journal of Physics Chemistry2003，107，10： | 1 |
| 11 | The endocannabinoid system in renal cells: regulation of Na+ transport by CB1 receptors through distinct cell signaling pathways显示文摘 | Sampaio L S Taveira Da Silva R Lima D | 2015 | Br J Pharmacol2015，172，19： | 1 |
| 12 | Diagnostic and therapeutic joint injections显示文摘 | Masala S Fiori R Bartolucci DA | 2010 | Semin Intervent Radiol2010，27，2： | 1 |
| 13 | Eevelopment and characterization of a cheese analogue containing aqueous soya extract (soya mill), whey and cow milk显示文摘 | Pereirag V Antunes L A F Dos Santos Ferreira da Silva R S | 1992 | Arquivo de Biologiay Tecnica1992，35，： | 1 |
| 14 | Radiographics Pattern Recognition of Welding Defects Using Linear Classifiers显示文摘 | R R da Silva M H S Siqueira L P Caloba etc | 2001 | Insight2001，，10： | 1 |
| 15 | Small strain viscoelastic behaviour of wheat gluten-pentosan mixtures 显示文摘 | Santos D M J Monteiro S R Da Silva J A L | 2005 | Eur Food Res Technol2005，，221： | 1 |
| 16 | An epigas- tric swelling显示文摘 | RAJAGOPALAN S ROBINSON DA HARGEST R | 2004 | J R Soc Med2004，97，8： | 1 |
| 17 | Anticancer, antichemotactic and antimicrobial activities of marine sponges collected off the coast of Santa Catarina, southern Brazil显示文摘 | Noel R Monks Clea Lerner Amélia T Henriques Fabiane M Farias Elfrides E.S Schapoval Edna S Suyenaga Adriana B da Rocha Gilberto Schwartsmann Beatriz Mothes | 2002 | Journal of Experimental Marine Biology and Ecology2002，，1： | 1 |
| 18 | Bad design, bad practices, bad bugs: frustrations in controlling an outbreak of Elizabe- thkingia meningoseptica in intensive care units 显示文摘 | Balm MN Salmon S Jureen R Teo C Mahdi R Seetoh T Teo JT Lin RT Fisher DA | 2013 | J Hosp Infect2013，85，2： | 1 |
| 19 | Penile lengthening for traumatic penile amputation due to ritual circumcision:a case report显示文摘 | Silfen R Hudson DA McCulley S | | 0，，03： | 1 |
| 20 | An antimicrobial activity of cytolytic T cells mediated by granulysin显示文摘 | Hanson DA Teitelbaum R | 1998 | Science1998，282，： | 1 |
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