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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Design of TRIP Steel With High Welding and Galvanizing Performance in Light of Thermodynamics and Kinetics显示文摘A new type of transformation induced plasticity (TRIP) steel with not only high strength and high ductility but also superior welding and galvanizing properties was designed and developed recently. Low carbon and low silicon content were preliminarily selected with the aim of meeting the requirements of superior quality in both welding and galvanizing. Phosphorus was chosen as one of the alloying elements, because it could reduce carbon activity in cementite and increase the stability of austenite. In addition, the possibility of phosphorus segregating at grain boundary was also discussed by thermodynamics as well as kinetics. Phase diagram was estimated at high temperature and the composition of the steel was then selected in the hyperperitectic range to avoid problems, which might occur in sheet steel continuous casting. Phase diagram in the inter-critical temperature was estimated for the steel to obtain the starting temperature of fast cooling. For understanding the minimum rate of fast cooling, pearlite growth kinetics was calculated with self-developed diffusion coefficients of elements in grain boundary. Overaging temperature was determined through the calculation of T0 temperature by both equilibrium and para-equilibrium assumptions, which was different from the current determination, which is only based on an equilibrium estimation. | LI Lin DE COOMAN B C LIU Ren-dong VLEUGELS j ZHANG Mei SHI Wen | 2007 | Journal of Iron and Steel Research(International)2007，14，6： | 13 |
| 3 | 酒精摄入、心脏生物标志物和心房颤动风险与不良结局显示文摘酒精摄入和新发心房颤动相关性证据不一,尤其是在低剂量下。该研究评估欧洲队列在整个饮酒范围内酒精摄入、生物标志物和新发心房颤动的关系。方法和结果:在一个以社区为基础的汇集队列中,研究者随访107845人,以评估酒精摄入(酒精种类和饮酒方式)与新发心房颤动的关系。研究者收集经典心血管病危险因素和新发心力衰竭的信息,并检测生物标记物氨基末端脑钠肽前体和高敏肌钙蛋白I。 | 陈嘉睿(译) 练桂丽((审校) Csengeri D Sprünker NA Di Castelnuovo A Niiranen T Vishram-Nielsen JK Costanzo S S derberg S Jensen SM Vartiainen E Donati MB Magnussen C Camen S Gianfagna F L chen ML Kee F Kontto J Mathiesen EB Koenig W Stefan B de Gaetano G J rgensen T Kuulasmaa K Zeller T Salomaa V Iacoviello L Schnabel RB | 2021 | 中华高血压杂志2021，29，2： | 9 |
| 4 | Leukemia:研究鉴定出与34种AML白血病亚群相关联的基因突变显示文摘针对成年急性髓细胞白血病(acute myeloid leukemia,AML)患者的一项新的大型研究将80种癌症相关基因突变与5种AML亚型相关联。这5种AML亚型可通过特异性的染色体异常加以确定。在未来,这些发现可能有助指导基因突变测试和治疗决策。 | A-K Eisfeld K Mrózek J Kohlschmidt D Nicolet S Orwick C J Walker K W Kroll J S Blachly A J Carroll J E Kolitz B L Powell E S Wang R M Stone A de la Chapelle J C Byrd C D Bloomfield | 2017 | 现代生物医学进展2017，17，15： | 7 |
| 5 | Effect of Temperature and Strain Rate on Dynamic Properties of Low Silicon TRIP Steel显示文摘The dynamic tensile test of 0·11C-0·62Si-1·65 Mn TRIP steel was carried out at different strain ratesand test temperatures . The results showthat both temperature and strain rate affect the retained austenite trans-formation . At high strain rates ,the uniformelongation decreases , whereas the total elongation and energy absorp-tionincrease . The tensile strengthis less strain rate sensitive . With raising test temperature ,the tensile strengthis reduced and the mechanical properties generally deteriorate ,especially at 110 ℃. However ,excellent mechani-cal properties were obtained at 50 ℃and 75 ℃. | TIAN Rong LI Lin B C De Cooman WEI Xi-chen SUN Peng | 2006 | Journal of Iron and Steel Research(International)2006，13，3： | 5 |
| 6 | Thiopurine-methyltransferase variants in inflammatory bowel disease:Prevalence and toxicity in Brazilian patients显示文摘AIM:To analyze the prevalence of thiopurine-methyltransferase(TPMT)genotypes and their associationwith drug toxicity in inflammatory bowel disease(IBD)patients from southeastern Brazil.METHODS:A total of 219 consecutive patients with IBD,of which 146 had Crohn’s disease and 73 had ulcerative colitis,regularly seen at the outpatient unit of the Division of Gastroenterology at the University Hospital Pedro Ernesto of the State University of Rio de Janeiro,a tertiary referral center,were enrolled in this study from February 2009 to January 2011.We analyzed the presence of major TPMT genetic variants(TPMT*2,*3A,*3C)in IBD patients by means of a specific allele and RFLP-PCR.Genomic DNA was isolated from peripheral blood leukocytes by proteinase-K/Sodium Dodecyl Sulfate digestion and phenol-chloroform extraction.TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes were detected by real-time polymerase chain reaction followed by direct sequencing with specific primers.Clinical data were systematically recorded,and correlated with the genotype results.RESULTS:The distribution of the selected TPMT gene polymorphism TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes was 3.6%,5.4%,and 7.7%of the patients,respectively.Among the side effects recorded from patients taking azathioprine,14 patients presented with pancreatitis and/or an elevation of pancreatic enzymes,while 6 patients had liver toxicity,and 2 patients exhibited myelosuppression/neutropenia.TPMT polymorphisms were detected in 37/219 patients(8 heterozygous for*2,11 heterozygous for*3A,and 18 heterozygous for*3C).No homozygotic polymorphisms were found.Despite the prevalence of the TPMT*3C genotype,no differences among the genotype frequencies were significant.Although no association was detected regarding myelotoxicity or hepatotoxicity,a trend towards the elevation of pancreatic enzymes was observed for TPMT*2 and TPMT*3C genotypes.CONCLUSION:The prevalence of TPMT genotypes was high among Brazilian patients.Variants genes*2and*3C may be associated with azathioprine pancreatic toxicity in a IBD southeastern Brazilian population. | Ana Teresa P Carvalho Barbara C Esberard Renata S B Fróes Davy C M Rapozo Ana B Grinman Tatiana A Simo Juliana C V C Santos Antonio José V Carneiro Luis Felipe Ribeiro-Pinto Heitor S P de Souza | 2014 | World Journal of Gastroenterology2014，20，12： | 3 |
| 7 | Histological and molecular classification of gliomas显示文摘Rev Neurol (Paris). 2008 June-July;164(6-7):505-515. Epub 2008 Jun 10.Gliomas are the most frequent tumors of the central nervous system. The WHO classification, based on the presumed cell origin,distinguishes astrocytic,oligodendrocytic and mixed gliomas. A grading system is based on the presence of the following criteria: in- | Figarella-Branger D Colin C Coulibaly B Quilichini B Maues De Paula A Fernandez C Bouvier C | 2008 | 中国神经肿瘤杂志2008，6，2： | 3 |
| 8 | Acute fatty liver of pregnancy associated with severe acute pancreatitis:A case report显示文摘Acute fatty liver of pregnancy is a rare disease that affects women in the third trimester of pregnancy. Although infrequent, the disease can cause maternal mortality. The diagnosis is not always clear until the pregnancy is terminated, and significant complications, such as acute pancreatitis, can occur. Pancreatic involvement typically only occurs in severe cases after the development of hepatic and renal impairment. To date, little knowledge is available regarding how the disease causes pancreatitis. Treatment involves supportive measures and pregnancy interruption. In this report, we describe a case of a previously healthy 26-year-old woman at a gestational age of 27 wk and 6 d who was admitted with severe abdominal pain and vomiting. This case illustrates the clinical and laboratory overlap between acute fatty liver of pregnancy and pancreatitis, highlighting the difficulties in differentiating each disease. Furthermore, the hypothesis for this overlapping is presented, and the therapeutic options are discussed. | Cássio Vieira de Oliveira Alecsro Moreira Julio P Baima Leticia de C Franzoni Talles B Lima Fabio da S Yamashiro Kunie Yabuki Rabelo Coelho Ligia Y Sassaki Carlos Antonio Caramori Ferno G Romeiro Giovanni F Silva | 2014 | World Journal of Hepatology2014，6，7： | 3 |
| 9 | Mutation analysis of the RPGR gene reveals novel mutations in south European patients with X-linked retinitis pigmentosa显示文摘 | Miano MG Testa F Strazzullo M Trujillo M De Bernardo C Grammatico B | | 0，，： | 2 |
| 10 | 有氧运动联合阻抗运动对难治性高血压患者动态血压的降低作用更为持久:一项随机交叉试验显示文摘该研究比较有氧运动、阻抗运动及联合运动对难治性高血压(refractory hypertension,RH)和非难治性高血压(NON-RH)患者血压的短期影响。方法:招募患者20例(RH 10例和NON-RH 10例),随机进行三种运动训练或对照训练。试验训练结束后监测24h动态血压。结果:RH患者在有氧运动、阻抗运动及联合运动后动态血压降低。联合运动后日间和夜间动态血压均降低。有氧运动对日间血压的影响更为显著,而阻抗运动降低夜间血压的幅度较大。仅阻抗运动降低NON-RH患者的收缩压,三种运动均可降低舒张压。 | 袁源(摘译) 练桂丽(审校) Pires NF Coelho-Júnior HJ Gambassi BB deFaria APC Ritter AMV de Andrade Barboza C Ferreira-Melo SE Rodrigues B Júnior HM | 2021 | 中华高血压杂志2021，29，1： | 2 |
| 11 | A survey of models,analysis tools and compensation menthods for the control of machines with friction 显示文摘 | ARMSTRONG-HELOUVRY B DUPONT P CANUDAS DE WIT C | 1994 | Automatica1994，30，7： | 2 |
| 12 | Time course of cell biological events evoked in legume root hairs by Rhizobium Nod factors: State of the art 显示文摘 | LHUISSIER F G P DE RUIHTER N C A SIEBERER B J | 2001 | Ann Bot2001，87，： | 2 |
| 13 | A controlled study of the effects of RU58841, a non-steroidal antiandrogen, on human hair production by balding scalp grafts maintained on testosterone-conditioned nude mice 显示文摘 | De Brouwer B Tetelin C Leroy T | 1997 | Br J Dermatol1997，137，5： | 2 |
| 14 | Cardiac resynchronization therapy for the treatment of heart failure in patients with intraventricular conduction delay and malignant ventricular tachyarrhythmias显示文摘 | Steven L Higgins John D Hummel Imran K Niazi Michael C Giudici Seth J Worley Leslie A Saxon John P Boehmer Michael B Higginbotham Teresa De Marco Elyse Foster Patrick G Yong | 2003 | Journal of the American College of Cardiology2003，，8： | 2 |
| 15 | Competition between fusion-evaporation and multifragmentation in central collisions in ^(58)Ni+^(48)Ca at 25A MeV显示文摘The experimental data concerning the58Ni+48Ca reaction at Elab(Ni)=25A MeV,collected by using the CHIMERA 4π device,have been analyzed in order to investigate the competition among different reaction mechanisms for central collisions in the Fermi energy domain.As a main criterion for centrality selection we have chosen the flow angle(flow) method,making an event-by-event analysis that considers the shape of events,as it is determined by the eigenvectors of the experimental kinetic-energy tensor.For the selected central events(flow >60°) some global variables,good to characterize the pattern of central collisions have been constructed.The main features of the reaction products were explored by using different constraints on some of the relevant observables,like mass and velocity distributions and their correlations.Much emphasis was devoted,for central collisions,to the competition between fusion-evaporation processes with subsequent identification of a heavy residue and a possible multifragmentation mechanism of a well defined(if any) transient nuclear system.Dynamical evolution of the system and pre-equilibrium emission were taken into account by simulating the reactions in the framework of transport theories.Different approaches have been envisaged(dynamical stochastic BNV calculations + sequential SIMON code,QMD,CoMD,etc.).Preliminary comparison of the experimental data with BNV calculations shows reasonable agreement with the assumption of sequential multifragmentation emission in the mass region of IMFs close to the heavy residues.Possible deviations from sequential processes were found for those IMFs in the region of masses intermediate between the mass of heavy residues and the mass of light IMFs.Further simulations are in progress.The experimental analysis will be enriched also by information obtained inspecting the IMF-IMF correlation function,in order to elucidated the nature of space-time decay property of the emitting source associated with events having the largest IMF multiplicity. | FRANCALANZA L ABBONDANNO U AMORINI F BARLINI S BINI M BOUGAULT R BRUNO M CARDELLA G CASINI G AGOSTINO M D' De FILIPPO V De SANCTIS J GERACI E GIUSSANI A GRAMEGNA F GUIOT B KRAVCHUK V La GUIDARA E LANZALONE G Le NEINDRE N MAIOLINO C MARINI P MORELLI L OLMI A PAGANO A PAPA M PIANTELLI S PIRRONE S POLITI G POGGI G PORTO F RUSSOTTO P RIZZO F VANNINI G VANNUCCI L | 2013 | Nuclear Science and Techniques2013，24，5： | 2 |
| 16 | A Survey of Models, Analysis Tools and Compensation Methods for the Control of Machines with Friction 显示文摘 | ARMSTRONG-HELOUVRY B DUPONT P DE WIT C C | 1994 | Automatica1994，30，： | 1 |
| 17 | Kinetics of phase transformation in steels: a new method analyzing dilatometric results显示文摘 | Zhao J Z Mesplont C De Cooman B C | 2001 | ISIJ International2001，41，5： | 1 |
| 18 | A global geometric framework for nonlinear dimensionality reduction显示文摘 | Tenenbanm J B De Silva V and Langford J C | 2000 | Science2000，290，5500： | 1 |
| 19 | Newborn hearing screening by transient evoked otoacoustic emissions: analysis of response as a function of risk factors 显示文摘 | DE CAPUA B DE FELICE C COSTANTINI D | 2003 | Acta Otorhinolaryngol Ital2003，23，： | 1 |
| 20 | A Global Geometric Framework for Nonlinear Dimensionality Reduction 显示文摘 | Tenengaum J B De Silva V Langford J C | 2000 | Science2000，290，5500： | 1 |
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