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| 1 | 乙型肝炎病毒导致的肝硬化伴肝癌患者血清中N糖组学改变显示文摘肝细胞癌(HCC)是最常见的肿瘤和最主要的死因之一,多发生于HBV和HCV感染导致的肝硬化患者,筛查肝硬化人群,早期诊断HCC可降低肿瘤的病死率。甲胎蛋白(AFP)是目前广泛应用的辅助诊断HCC的血清学指标,是对B超、CT等影像学诊断的有效补充。最近的荟萃分析表明,不同研究论文报道的AFP的灵敏度和特异度有很大的不同,这种现象不能完全用AFP的临界值不同解释。血清中的N糖蛋白主要由肝脏和B淋巴细胞合成,N糖成分的改变可反应肝脏或B淋巴细胞功能的改变,糖链的改变常常反应出机体的异常改变。糖组学在诊断领域的应用曾经因为缺少合适的分析技术而受限制,血清中N糖组学分析技术克服了这一屏障。本研究的目的是评价血清中N糖指纹图谱应用于乙型肝炎后肝硬化伴肝癌辅助诊断的意义。 | 刘学恩 Liesbeth Desmyter 高春芳 Wouter Laroy Sylviane Dewaele Valerie Vanhooren 王玲 庄辉 Nico Callewaert Claude Libert Roland Contreras 陈翠英 | 2008 | 中华肝脏病杂志2008，16，1： | 11 |
| 2 | N-glycomic changes in hepatocellular carcinoma patients with liver cirrhosis induced by hepatitis B virus 显示文摘 | Liu XE Desmyter L Gao CF | 2007 | Hepatology2007，46，5： | 1 |
| 3 | Normal and transplanted lateral knee menisci:evaluation of extrusion using magnetic resonance imaging and ultrasound显示文摘 | Verdonk P Depaepe Y Desmyter S | 2004 | Knee Surg Sports Traumatol Arthrosc2004，12，5： | 1 |
| 4 | Selection and identification of single domain antibody fragment from camel heavychain antibodies显示文摘 | Ghahroudi M A Desmyter A Wyns L | | 0，，： | 1 |
| 5 | Potent enzyme inhibitors derived dromedary heavy chain antibody显示文摘 | Lauwereys M Ghahroudi M A Desmyter A | | 0，，： | 1 |
| 6 | Antivirial portrait series: 4 polysulfates as inhabitors of HIV and other enveioped viruses显示文摘 | Wirvrouw M Desmyter J Clercq E D | 1994 | Antiviral Chem Chenother1994，5，6： | 1 |
| 7 | Normal and transplanted lateral knee menisci:evaluation of extrusion using magnetic resonance imaging and ultrasound显示文摘 | Verdonk P Depaepe Y Desmyter S | 2004 | Knee Surg Sports Traumatol Arthrosc2004，12，： | 1 |
| 8 | Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivatives显示文摘 | Pauwels R Andries K Desmyter J | 1990 | Nature1990，343，6257： | 1 |
| 9 | The association of gonorrhea and syphilis with premature birth and low birthweight 显示文摘 | Donders GG Desmyter J De Wet DH | 1993 | Genitourin Med1993，69，2： | 1 |
| 10 | N-glycomicchanges in hepatocellular carcinoma patients with livercirrhosis induced by hepatitis B virus显示文摘 | Liu XE Desmyter L Gao CF | 2007 | Hepatology2007，46，5： | 1 |
| 11 | The relationship between time perspective and subjective well-being of older adults显示文摘 | Desmyter F Rudi DR | 2012 | Psychologica Belgica2012，52，1： | 1 |
| 12 | Normal and transplanted lateral knee menisci:evaluation of extrusion using magnetic resonance imaging and ultrasound显示文摘 | Verdonk P Depaepe Y Desmyter S | 2004 | Knee Surg Sports Traumatol Arthrosc2004，12，5： | 1 |
| 13 | N-Glycomic changes in hepatocellular carcinoma patients with liver cirrhosis induced by hepatitis B virus 显示文摘 | Liu XE Desmyter L Gao CF | 2007 | Hepatology2007，46，5： | 1 |
| 14 | N -glycomic chan- ges in hepatocellular carcinoma patients with liver cirrhosis in- duced by hepatitis B virus 显示文摘 | LIU XE DESMYTER L GAO CF | 2007 | Hepatology2007，46，5： | 1 |
| 15 | A camelid antibody fragment inhibits the formation of amyloid fibrils by human lysozyme显示文摘 | Dumoulin M Last AM Desmyter A | 2003 | Nature2003，424，6950： | 1 |
| 16 | Domain swapping of a llama VHH domain builds a crystalwide beta-sheet structure显示文摘 | Spinelli S Desmyter A Frenken L | 2004 | FEBS Letters2004，564，12： | 1 |
| 17 | Analysis of the in planta antiviral activity of elderberry ribosome-inactivating proteins 显示文摘 | Vandenbussche F Desmyter S Ciani M | 2004 | Eur J Biochem2004，271，8： | 1 |
| 18 | Selection and identification of single domain antibody fragments from camel heavy-chain antibodies显示文摘 | Arbabi Ghahroudi M Desmyter A Wyns L | 1997 | FEBS Lett1997，414，3： | 1 |
| 19 | FAF1,a gene that is disrupted in cleft palate and has conserved function in zebrafish显示文摘 | Ghassibe-Sabbagh M Desmyter Lv Langenberg T | 2011 | Am J Hum Genet2011，88，2： | 1 |
| 20 | Structur-al and functional neuroimaging studies of the suicidal brain 显示文摘 | DESMYTER S VAN HEERINGEN C AUDENAERT K | 2011 | Prog Neuropsychopharmacol Biol Psychiatry2011，35，4： | 1 |
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