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| 1 | Breath test for differential diagnosis between small intestinal bacterial overgrowth and irritable bowel disease:An observation on non-absorbable antibiotics显示文摘AIM: To estimate the prevalence of small intestine bacterial overgrowth (SIBO) among patients with an earlier diagnosis of irritable bowel disease (IBS) in our geographical area, and to collect information on the use of locally acting non-absorbable antibiotics in the management of SIBO. METHODS: A non-interventional study was conducted in 73 consecutive patients with a symptom-based diagnosis.. RESULTS: When the patients underwent a 'breath test', 33 (45.2%) showed the presence of a SIBO. After treatment with rifaximin 1200 mg/d for seven days in 32 patients, 19 (59.4%) showed a negative 'breath test' one week later as well as a significant reduction of symptoms, thus confirming the relationship between SIBO and many of the symptoms claimed by patients. In the other 13 patients, 'breath test' remained positive, and a further cycle of treatment with ciprofloxacin 500 mg/d was given for 7 additional days, resulting in a negative 'breath test' in one patient only. CONCLUSION: (1) about half of the patients with a symptomatic diagnosis of IBS have actually SIBO, which is responsible for most of the symptoms attributed to IBS; (2) only a 'breath test' with lactulose (or with glucose in subjects with an intolerance to lactose) can provide a differential diagnosis between IBS and SIBO, with almost identical symptoms; and (3) the use of non-absorbable antibiotics may be useful to reduce the degree of SIBO and related symptoms; it must be accompanied, however, by the correction of the wrong alimentary habits underlying SIBO. | I Esposito A de Leone G Di Gregorio S Giaquinto L de Magistris A Ferrieri G Riegler | 2007 | World Journal of Gastroenterology2007，13，45： | 8 |
| 2 | Identification and characterization of Trichoderma species aggressive to Pleurotus in Italy显示文摘In the late 1980’s the deve lop ment of a severe epidemic of green mold caused by Trichoderma spp. was not ed in the commercial production of Agaricus bisporus (champignon) in the U nited Kingdom, North America, Spain and Holland, which caused extensive economic losses. The parasitic fungi isolated from the edible mushroom belonged to four biotypes, Th1, Th2, Th3 and Th4 of T. harzianum. However, among these biotypes, only Th2 (since c lassified as T. aggressivum f. europaeum) and Th4 (T. aggressivum f. aggressivum) were identified as the fungi causing problems in Agaricus production. In general, mushroom compost hosts both aggressive and innocuous is olates of Trichoderma, which are not morphologically distinguishable. Abo ut four years ago, a problem with green mold became apparent in the production o f Pleurotus ostreatus in Northern Italy, which eventually developed to a c risis situation in the South two years later and threatened to seriously comprom ise the Pleurotus market. This study was initiated to: isolate and identif y the aggressive fungi, then morphologically, physiologically and genetically characterize the isolates, dete rmine the source and phases of infection, and study methods of control. Samples were obtained from different phases of compost preparation at the locality of a major producer and supplier of compost to the mushroom industry in Southern Ital y, and microbial counts were conducted. Although the presence of Trichoderma was detected in the initial stages of composting, this value was reduced to zero from the phase of pasteurization to seeding with Pleurotus. Trichoderma infestations were noted in the packaged Pleurotus bales at various time s during the incubation phase (7-15 days after seeding) and after shipping to th e mushroom greenhouses, where the pathogen infestations greatly reduced the qual ity and quantity of the mushroom yield, as well as the number of potential harvest cycles. Preliminary r esults from the morphological and genetic characterization of Trichoderma isolates parasitic to Pleurotus indicated that they are different from bot h T. aggressivum forms parasitic to Agaricus, and the majority of the isolates probably belong to the species T. harzianum. In vitr o confrontation plates were performed with 26 isolates of aggressive Trich oderma obtained from compost, three Trichoderma isolates used in biolog ical control and 12 varieties of Pleurotus. No inhibitory effect was obse rved between any of the Trichoderma isolates with Pleurotus, althou gh some growth inhibition was caused by the biocontrol isolates of Trichoderm a on some of the aggressive isolates. The temperature optimum for Pleurotus growth was at 28 ℃, whereas Trichoderma grew well at a wider range (20- 28 ℃), and exceeded the growth rate of Pleurotus by three times at 25 ℃. T he pH optimum for the growth of Pleurotus was alkaline (pH 8-9) whereas Trichoderma preferred acidic-neutral pH (5-7) . Various commercial fungicides used in agriculture (procloraz, thiabendazole, dichloran, benomyl, p r opiconazole, thiofanatomethyl) were tested against the aggressive and biocontro l isolates of Trichoderma, as well as the different varieties of Pleuro tus to determine dose response curves and combinations that would inhibit spo re germination, mycelial growth and subsequent sporulation. Both procloraz and thiabendazole, which are pesticides allowed in e dible mushroom production, were found to control the growth of the aggressive Trichoderma isolates and did not have a negative effect on Pleurotus. | Woo S L Di Benedetto P Senatore M Abadi K Gigante S Soriente I Ferraioli S Scala F Lorito M | 2004 | 浙江大学学报(农业与生命科学版)2004，30，4： | 2 |
| 3 | Genetic improvement of Trichoderma ability to induce systemic resistance显示文摘The beneficial applications of Trichoderma spp. in agriculture include not only the control of plant pathogens, but also the improvement of plant growth, micronutrient availability, and plant tolerance to abiotic stress. In addition, it has been suggested that these fungi are able to increase plant disease resistance by activating induced systemic resistance (ISR) . The mode of action of these beneficial fungi in the Trichoderma -plant-pathogen interaction are many, complex and not completely understood. Numerous lytic enzymes have been characterized, the encoding genes (ech42 gluc78, nag1 from T. atroviride strain P1) cloned, and their role in biocontrol demonstrated. The corresponding biocontrol-related inducible promoters have been used in a reporter system based on the Aspergillus niger glucose oxidase gene (goxA) to monitor biocontrol activity. Glucose oxidase catalyzes the oxygen-dependent oxidation of D-glucose to D-glucono-1,5-lactone and hydrogen peroxide; this latter compound is known to have an antifungal effect and activate the plant defence cascade, thus increasing resistance to pathogen attack. T. atroviride P1 transformants with various promoters gox were tested as seed coating treatments on bean seeds planted in soil infested with a soilborne fungal pathogen. Successively, the emergent leaves were inoculated with a foliar pathogen to determine the effect of the GOX transformants on biocontrol and resistance to pathogen attack. Inoculations with the P1-GOX transformants not only reduced disease symptoms caused by a soil pathogen, but also the lesions of various foliar pathogens applied far from the Trichoderma colonization, thus activating ISR. A similar approach is being use to genetically improve T. harzianum T22, a rhizosphere competent and commercially marketed strain not transformed yet, by using four different gox gene constructs under the control of constitutive and inducible promoters. Plasmids have been introduced in Trichoderma by protoplasts co-transformation. hygromicin resistant progeny selected, and mitotically stable transformants analysed to confirm the presence of the novel enzyme activity. Progenies are being tested for biocontrol ISR inducing activity. | Ciliento R Woo S L Di Benedetto P Ruocco M Scala F Soriente I Ferraioli S Brunner K Zeilinger S Mach R L Lorito M | 2004 | 浙江大学学报(农业与生命科学版)2004，30，4： | 2 |
| 4 | Placement of covered self-expandable metal biliary stent for the treatment of severe postsphincterotomy bleeding:outcomes of two cases显示文摘 | Di Pisa M Tarantino I Barresi L | | 0，，： | 1 |
| 5 | Modeling guided wave propagation with appli-cation to the long-range defect detection in railroad tracks显示文摘 | Bartoli I Di Scalea F L Fateh M | 2005 | NDT&EInternational2005，38，5： | 1 |
| 6 | The effects of power and strength training on bone mineral density in prem- enopausal women显示文摘 | Gray M Di Brezzo R Fort I L | 2013 | Journal of Sports Medicine and Physical Fitness2013，53，4： | 1 |
| 7 | Finite-length analysis of low-density parity-check codes on the binary erasure channel 显示文摘 | C Y Di D Proietti I E Telatar T J Richardson R L Urbanke | 2002 | IEEE Trans Inform Theory2002，48，6： | 1 |
| 8 | Modeling wave propagation in damped waveguides of ar- bitrary cross-section 显示文摘 | BARTOLI I MARZANI A DI SCALEA F L | 2006 | Journal of Sound and Vibra- tion2006，295，3： | 1 |
| 9 | Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB 显示文摘 | MEDINA D L DI PAOLA S PELUSO I | 2015 | Nat Cell Biol2015，17，3： | 1 |
| 10 | Molecular characterization and expression of a heat-shock cognate 70(Hsc70)and a heat-shock protein 70(HSP70)cDNAs in Rana(Pelophylax)lessonae embryos显示文摘 | Simoncelli F Morosi L Di Rosa I | 2010 | Comp Biochem Physiol A Mol Integr Physiol2010，156，4： | 1 |
| 11 | Chemo- sensitization of Solid Tumors by Modulation of Resistance Mechanisms 显示文摘 | Cree I A Knight L Di Nicolantonio F | 2002 | Curr Opin Investing Drugs2002，3，4： | 1 |
| 12 | Genome sequence and analysis of the tuber crop potato显示文摘 | Xu X Pan S Cheng S Zhang B Mu D Ni P Zhang G Yang S Li R Wang J Orjeda G Guzman F Tones M Lnzano R Ponce O Martinez D De la Cruz G Chakrabarti S K Patil V U Skryabin K G Kuznetsov B B Ravin N V Kolganova T V Beletsky A V Mardanov A V Di Genova A Bolser D M Martin D M Li G Yang Y Kuang H Hu Q Xiong X Bishop G J Sagredo B Mejia N Zagorski W Gromadka R Gawor J Szczesny P Huang S Zhang Z Liang C He J Li Y He Y Xu J Zhang Y Xie B Du Y Qu D Bonierbale M Ghislain M Herrera Mdel R Giuliano G Pietrella M Perrotta G Faeella P O 'Brien K Feingold S E Barreiro L E Massa G A Diambra L Whitty B R Vaillancourt B Lin H Massa A N Geoffroy M Lundback S DellaPenna D Buell C R Sharma S K Marshall D F Waugh R Bryan G J Destefanis M Nagy I Milbourne D Thomson S J Fiefs M Jacobs J M Nielsen K L Sonderkaer M Iovene M Tortes G A Jiang J Veilleux R E Bachem C W de Boer J Bonn T Kloosterman B van Eck H Datema E Hekkert B Goverse A van Ham R C Visser R G | 2011 | Nature2011，475，7355： | 1 |
| 13 | Chain extension and foaming of recycled PET in extrusion equipment显示文摘 | L Di Maio I Coccorullo S Montesano | 2005 | Macromolecular Symposia2005，228，1： | 1 |
| 14 | Estimation of motor vehicle toxic emissions in the urban area of Mexico City显示文摘 | SCHIFTER I DIAZ L LOPEZ-SALINAS E | 2000 | Environmental Science and Technology2000，34，17： | 1 |
| 15 | Structure and dynamics of Antarctic fish neuroglobin assessed by computer simulations显示文摘 | Boron I Russo R Boechi L Cheng CHC di Prisco G Estrin DA Verde C Nadra AD | | 0，，： | 1 |
| 16 | Simultaneous measurement of gastric emptying of a solid meal by ultrasound and by scintigraphy 显示文摘 | Sembenini C Heading RC Giorgetti RG Montemenzzi S Zamboni M Di Benedetto P Brighenti F Vantini I | 1999 | Am J Gastroenterol1999，94，10： | 1 |
| 17 | Regulatory T cells and extraeorporeal photochemotherapy: correlation with clinical response and decreased frequency of proinflammatory T ceils 显示文摘 | Di Biaso I Di Maio L Bugarin C | 2009 | Transplantation2009，87，9： | 1 |
| 18 | Characterization of H5N2 influenza viruses from Italianpoultry显示文摘 | Donatelli I Campitelli L Di Trani L | 2001 | J Gen Virol2001，82，3： | 1 |
| 19 | The influence of im- plant diameter and length on stress distribution of osseointegrated im- plants related to crestal bone geometry: a three-dimensional finite el- ement analysis 显示文摘 | Baggi L Cappelloni I Di Girolamo M | 2008 | J Prosthet Dent2008，100，6： | 1 |
| 20 | Optimisation and scale-up of a highly-loaded 5-asa multi-particulate dosage form using a factorial approach显示文摘 | Di Pretoro G Zema L Palugan L Wilson D I Rough S L Gazzaniga A | 2012 | European Journal o f Pharmaceutical Sciences2012，45，12： | 1 |
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