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| 1 | Development of hepatorenal syndrome in bile duct ligated rats显示文摘AIM: To evaluate in bile duct ligated rats whether there were progressive alterations of renal function without changes in histopathology. METHODS: Male Wistar rats were submitted to sham-surgery or bile duct ligation (BDL) and divided according to the post-procedure time (2, 4 and 6-wk). To determine renal function parameters, rats wereplaced in metabolic cages and, at the end of the experiment, blood and urine samples were obtained. Histology and hydroxyproline content were analyzed in liver and renal tissue. RESULTS: Rats with 2 wk of BDL increased free water clearance (P = 0.02), reduced urinary osmolality (P = 0.03) and serum creatinine (P = 0.01) in comparison to the sham group. In contrast, rats at 6 wk of BDL showed features of HRS, including signif icant increase in serum creatinine and reductions in creatinine clearance, water excretion and urinary sodium concentration. Rats with 4 wk of BDL exhibited an intermediate stage of renal dysfunction. Progressive hepatic f ibrosis according to post-procedure time was confirmed by histology. The increased levels of liver hydroxyproline contrasted with the absence of structural changes in the kidney, as assessed by histology and unchanged hydroxyproline content in renal tissue. CONCLUSION: Our data show that BDL produced progressive renal dysfunction without structural changes in the kidney, characterizing HRS. The present model will be useful to understand the pathophysiology of HRS. | Regina M Pereira Robson AS dos Santos Eduardo A Oliveira Virgínia HR Leite Filipi LC Dias Alysson S Rezende Lincoln P Costa Lucíola S Barcelos Mauro M Teixeira Ana Cristina Sim■es e Silva | 2008 | World Journal of Gastroenterology2008，14，28： | 2 |
| 2 | Efficacy of CFRP- based techniques for the flexural and shear strengthening of concrete beams 显示文摘 | Barros J A O Dias S J E Lima J 1 T | 2007 | Cement and Concrete Composites2007，29，3： | 1 |
| 3 | Rapid silver staining and recover of PCR products separated in polyacrylamide gels显示文摘 | SANGUINETTI C J DIAS N E SIMPSON A J G | 1994 | Bio techniques1994，17，： | 1 |
| 4 | Rapid silver staining and recovery of PCR products separated on polyacrylamide gels 显示文摘 | SANGUINETTI C J DIAS NETO E SIMPSON A J | 1994 | Biotechniques1994，17，5： | 1 |
| 5 | Rapid silverstaining and recover of PCR products separated on polycrylamidegels显示文摘 | SANGUINETTI C J DIAS NETO E SIMPSON A J | 1994 | Biotechniques1994，17，5： | 1 |
| 6 | Rapid silver staining and recovery of PCR products separated on polyacrylamide gels polymerase chain reaction product recover显示文摘 | Sanguinetti C J Dias N E Simpson A J | 1994 | Biotechniques1994，17，5： | 1 |
| 7 | 显示文摘 | Pavan F A Dias S L P Lima E C | 2008 | Dyes Pigments2008，76，： | 1 |
| 8 | Nanosized and re- usable SiO2/ZrO2 catalyst for highly efficient biodiesel production by soybean ktransesterification显示文摘 | Faria E A Marques J S Dias I M | 2009 | Braz Chem Soc2009，20，： | 1 |
| 9 | Supracricoid laryngectomy with cricohyoidoepiglottopexy for advanced glottic cancer显示文摘 | LIMA R A FREITAS E Q DIAS F L | 2006 | Head Neck2006，28，： | 1 |
| 10 | Rapid silver staining and recovery of PCR products separated on polyacrylamide gels显示文摘 | Sanguinetti C J Dias Neto E Simpson A J | 1994 | Biotechniques1994，17，5： | 1 |
| 11 | Mechanical properties of hardened cement paste exposed to temperatures up to 700C (1292F)显示文摘 | Dias W P S Khoury G A Sullivan P J E | 1990 | Material Journal1990，87，2： | 1 |
| 12 | Rapid silver staining and recovery of PCR products separated on polyacrylamide gels显示文摘 | Sanguinetti C J Dias N E Simpson A J | 1994 | Biotechniques1994，17，： | 1 |
| 13 | Yellow passion-fruit shell as biosorbent to remove Cr(Ill) and Pb(11) from aqueous solution显示文摘 | Jacques R A Lima E C Dias S L P | 2007 | Separation and Purification2007，57，1： | 1 |
| 14 | Rapid silver staining and recovery of PCR products separated on polyacrylamide gels显示文摘 | Sanguinetti C J Dias Neto E Simpson A J | 1994 | Biotechniques1994，17，5： | 1 |
| 15 | Rapid silver staining and recover of PCR products separated on polyacrylamide gels 显示文摘 | Sanguinetti C J Dias N E Simpson A J G | 1994 | Bin- techniques1994，17，： | 1 |
| 16 | Rapid sliver staining and recovery of PCR products separated on polyacrylamide gels显示文摘 | Sanguinetti C J Dias Nero E Simpson A J | 1994 | Biotechniques1994，17，7： | 1 |
| 17 | Biogenicamine profile in unripe arabica coffee beans processed ac-cording to dry and wet met methods显示文摘 | Dias E C Pereira R G F A Bor6m F M | 2012 | Journal of Agri-cultural and Food Chemistry2012，60，16： | 1 |
| 18 | Seroprevalence of Anaplasma marginale in cattle from Center-South Region ofParan6 State, Brazil by a competitive ELISA test with recombi- nant MSP5-PR1 protein 显示文摘 | Marana E R Dias J A Freire R L | 2009 | Rev Bras Parasitol Vet2009，18，1： | 1 |
| 19 | Rapid silver stainingand recovery of PCR products separated on polyacrylamide gels显示文摘 | Sanguinetti C J Dias Neto E Simpson A J | 1994 | Biotechniques1994，17，5： | 1 |
| 20 | Rapid silver staining and recovery of PCR products separated on polyac- rylamide gels显示文摘 | Sanguinetti C J Dias Neto E Simpson A J | 1994 | Biotechniques1994，17，5： | 1 |
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