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| 1 | Device-associated infection rates, mortality, length of stay and bacterial resistance in intensive care units in Ecuador: International Nosocomial Infection Control Consortium's findings显示文摘AIM To report the results of the International Nosocomial Infection Control Consortium(INICC) study conducted in Quito, Ecuador.METHODS A device-associated healthcare-acquired infection(DAHAI) prospective surveillance study conducted from October 2013 to January 2015 in 2 adult intensive care units(ICUs) from 2 hospitals using the United States Centers for Disease Control/National Healthcare Safety Network(CDC/NHSN) definitions and INICC methods. RESULTS We followed 776 ICU patients for 4818 bed-days. The central line-associated bloodstream infection(CLABSI) rate was 6.5 per 1000 central line(CL)-days, the ventilator-associated pneumonia(VAP) rate was 44.3 per 1000 mechanical ventilator(MV)-days, and the catheterassociated urinary tract infection(CAUTI) rate was 5.7 per 1000 urinary catheter(UC)-days. CLABSI and CAUTI rates in our ICUs were similar to INICC rates [4.9(CLABSI) and 5.3(CAUTI)] and higher than NHSN rates [0.8(CLABSI) and 1.3(CAUTI)]- although device use ratios for CL and UC were higher than INICC and CDC/NSHN's ratios. By contrast, despite the VAP rate was higher than INICC(16.5) and NHSN's rates(1.1), MV DUR was lower in our ICUs. Resistance of A. baumannii to imipenem and meropenem was 75.0%, and of Pseudomonas aeruginosa to ciprofloxacin and piperacillin-tazobactam was higher than 72.7%, all them higher than CDC/NHSN rates. Excess length of stay was 7.4 d for patients with CLABSI, 4.8 for patients with VAP and 9.2 for patients CAUTI. Excess crude mortality in ICUs was 30.9% for CLABSI, 14.5% for VAP and 17.6% for CAUTI. CONCLUSION DA-HAI rates in our ICUs from Ecuador are higher than United States CDC/NSHN rates and similar to INICC international rates. | Estuardo Salgado Yepez Maria M Bovera Victor D Rosenthal Hugo A González Flores Leonardo Pazmino Francisco Valencia Nelly Alquinga Vanessa Ramirez Edgar Jara Miguel Lascano Veronica Delgado Cristian Cevallos Gasdali Santacruz Cristian Pelaéz Celso Zaruma Diego Barahona Pinto | 2017 | World Journal of Biological Chemistry2017,8,1: | 23 |
| 2 | Pioneering drugs for overactive bladder and detrusor overactivity: Ongoing research and future directions显示文摘The ongoing research on pioneering drug candidates for the overactive bladder(OAB) aimed to overcome the limitations of currently licensed pharmacotherapies, such as antimuscarinics, β3-adrenergic agents, and botulinum neurotoxin, has been reviewed performing a systematic literature review and web search. The review covers the exploratory agents alternative to available medications for OAB and that may ultimately prove to be therapeutically useful in the future management of OAB patients based on preclinical and early clinical data. It emerges that many alternative pharmacological strategies have been discovered or are under investigation in disease-oriented studies. Several potential therapeutics are known for years but still find obstacles to pass the clinical stages of development, while other completely novel compounds, targeting new pharmacological targets, have been recently discovered and show potential to translate into clinical therapeutic agents for idiopathic and neurogenic OAB syndrome. The global scenario of investigational drugs for OAB gives promise for the development of innovative therapeutics that may ultimately prove effective as first, combined or second-line treatments within a realistic timescale of ten years. | Emilio Sacco Salvatore Recupero Riccardo Bientinesi Giuseppe Palermo Daniele D'Agostino Diego Currò Pierfrancesco Bassi | 2015 | World Journal of Obstetrics and Gynecology2015,4,2: | 3 |
| 3 | Intestinal permeability test as a predictor of clinical course in Crohn’s disease显示文摘 | Renata D’Incà Vincenza Di Leo Giovanni Corrao Diego Martines Anna D’Odorico Cinzia Mestriner Carla Venturi Giuseppe Longo Giacomo Carlo Sturniolo | 1999 | The American Journal of Gastroenterology1999,,: | 2 |
| 4 | Calprotectin and lactoferrin in the assessment of intestinal inflammation and organic disease显示文摘 | Renata D’Incà Elisabetta Pont Vincenza Leo Antonio Ferronato Walter Fries Maria Grazia Vettorato Diego Martines Giacomo Carlo Sturniolo | 2007 | International Journal of Colorectal Disease2007,,4: | 2 |
| 5 | Oxygen related sediment microfabries in modern 'black shales', Gulf of California, Mexico显示文摘 | Diego T D Douglas R G | 1999 | Journal of Foraminifera Research1999,29,4: | 1 |
| 6 | The non-structural polyprotein 3ABC of foot-and mouth disease virus as a diagnostic antigen in ELISA to differentiate infected from vaccinated cattle显示文摘 | Diego M D Brocchi E Mackay D | 1997 | Arch Virol1997,142,: | 1 |
| 7 | The non-structural polyprotein 3ABC of foot-and-mouth disease virus as a diagnostic antigen in ELISA to differentiate infected from vaccinated cattle显示文摘 | DE DIEGO M BROCCHI E MACK AY D | 1997 | Arch Virol1997,142,10: | 1 |
| 8 | Calcination of calcium acetate and calcium magnesium acetate:effect of the reacting atmosphere显示文摘 | Adanez J Diego L F d Garcia-Labiano F | 1999 | Fuel1999,78,5: | 1 |
| 9 | Antifouling technology-past present and future steps towards efficient and environmen- tally friendly antifouling coatings显示文摘 | Diego M Y Soren K Kim D J | 2004 | Prog Org Coat2004,50,: | 1 |
| 10 | Effects of long-term azithromycin therapy on airway oxidativestress markers in non-cystic fibrosis bronchitctasis 显示文摘 | DIEGO A D MILARA J MARTINEZ-MORAG6N E | 2013 | Respirology2013,18,7: | 1 |
| 11 | Fluorescence and CD spectroscopic analysis of the α-chymotrypsin stabilization by the ionic liquid, 1-ethyl-3-methylimidazolium bis amide显示文摘 | Diego T D Lozano P Gmouh S Vaultier M Iborra J L | 2004 | Biotechnol Bioeng2004,88,: | 1 |
| 12 | Antifouling technology- past, present and future steps towards efficient and environ- mentally friendly antifouling coatings 显示文摘 | DIEGO M Y SOREN K KIM D J | 2004 | Progress in Organic Coatings2004,,50: | 1 |
| 13 | Synthesis of glyeidyl esters catalyzed by lipases in ionic liquids and supercritical carbon dioxide 显示文摘 | LOZANO P DIEGO T D CARRI D | 2004 | Journal of Molecular Catalysis A : Chemical2004,214,: | 1 |
| 14 | Efficiently combining positions and normals for precise 3D geometry显示文摘 | Diego N Szymon R James D | 2005 | ACM Transactions on Graphics2005,24,3: | 1 |
| 15 | The nonstrucrural protein 3ABC of foot-and-mouth disease virus as a diagnostic antigen in ELISA to differentiate infected from vaccinated cattle显示文摘 | De Diego M Brocchi E Mackay D | 1997 | Arch Virol1997,142,10: | 1 |
| 16 | Understanding structure-stability relationships of Candida antartica Lipase B in ionic liquids 显示文摘 | DIEGO T D LOZANO P GMOUH S | 2005 | Biomacromolecules2005,6,3: | 1 |
| 17 | Primary orbital lymphoua显示文摘 | Fausto T Germano D M Diego S | 2001 | Orbit2001,20,2: | 1 |
| 18 | Fluorescence and CD spectroscopic analysis of the α-chymotrypsin stabilization by the ionic liquid, 1-ethyl-3-methylimidazolium bis amide 显示文摘 | Diego T D Lozano P Gmouh S | 2004 | Biotechnol Bioeng2004,,88: | 1 |
| 19 | Over-stabilization of candida antarctica lipase by ionic liquids in estersynthesis显示文摘 | Lozano P De Diego T Carriie D | 2001 | Biotechnology Letters2001,23,: | 1 |
| 20 | Geospatial video monitoring of nearshore benthic habitats of western Biscayne Bay (Florida) using the shallow-water positioning system (SWaPS)显示文摘 | Diego L Gregory D Joseph E S | | 0,,1: | 1 |