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| 1 | New multi protein patterns differentiate liver fibrosis stages and hepatocellular carcinoma in chronic hepatitis C serum samples显示文摘瞄准:识别一多象用为肝纤维变性(F1-F2 ) 的察觉和区别的提高表面的激光 desorption/ionisation time-of-flight 团 spectrometry (SELDI-TOF-MS ) 的单个蛋白质标记一样的浆液蛋白质模式,在有长期的丙肝病毒(HCV ) 的病人的肝肝硬化(F4 ) andhepatocellular 癌(HCC ) 。方法:有 F1/F2 纤维变性的 39 个病人,的 Serumsamples 有 F4 纤维变性的 44 个病人,有我们重新申请到 CM10 数组并且分析了使用 SELDI-TOF ProteinChip 系统的 HCC 的 34 个病人(PBS-IIc;CiphergenBiosystems ) 在阴离子交换分别以后。所有病人 andhistologically 有长期的丙肝证实的纤维变性 stage/HCC。数据被 multivariatestatistical 技术和人工的神经网络为蛋白质模式分析。结果:4 肽 / 蛋白质 multimarkerpanel (7486, 12843, 44293 和 53598 Da ) 正确地在训练样品(AUROC0.943 ) 的 HCV 肝硬化对 HCV-HCC 的二方法比较与 100% 的敏感和 85% 的特性识别了 HCC。为 HCC 的鉴定的敏感和特性为随机的测试样品是 68% 和 80% 。肝脏硬化症的病人能被歧视有多使用 5peptide/protein 的 F1 或 F2 纤维变性的病人标记模式( 2873 , 6646 , 7775 , 10525 和 67867 Da )与100%和在训练样品( AUROC 0.976 )的85%的敏感和敏感和特性of80%的特性并且67%为随机的测试样品。有 APRI 分数 andalfa-fetopotein (法新社) 的简历标记分类器的联合改进了诊断表演。为肝纤维变性的 6646 Da 标记蛋白质作为 apolipoprotein C-I 被识别。结论:与蛋白质模式分析相结合的 SELDI-TOF-MS 技术与长期的丙肝在病人为肝肝硬化 andhepatocellular 癌的鉴定似乎是一条珍贵途径。最可能,不同浆液标记的联合将帮助以后识别肝肝硬化和早阶段的 hepatocellularcarcinomas。 | Thomas Gbel Sonja Vorderwülbecke Katarzyna Hauck Holger Fey Dieter Hussinger Andreas Erhardt | 2006 | World Journal of Gastroenterology2006，12，47： | 21 |
| 2 | FibroSURE^(TM) and FibroScan~ in relation to treatment response in chronic hepatitis C virus显示文摘AIM:To compare histological endpoint assessment using noninvasive alternatives to biopsy during treatment in a chronic hepatitis C virus(HCV)cohort.METHODS:Patients with chronic HCV were randomized to receive interferon-based therapy for 24(genotypes 2/3)or 48(genotype 1)wk.FibroSURE~TM(FS)was assessed at baseline and at week-12 post-treatment follow-up.Baseline biopsy for METAVIR was assessed by a single pathologist.FibroScan~ transient elastogra-phy(TE)was performed during treatment in a patient subset.RESULTS:Two thousand and sixty patients(n = 253 in Asia)were classif ied as METAVIR F0-1(n = 1682)or F2-4(n = 378).For F2-4,FS(n = 2055)had sensitiv-ity and specif icity of 0.87 and 0.61,respectively,with area under the receiver-operating curve of 0.82;corre-sponding values for TE(n = 214)and combined FS/TE(n = 209)were 0.77,0.88 and 0.88,and 0.93,0.68 and 0.88.Overall FS/TE agreement for F2-4 was 71%(κ = 0.41)and higher in Asians vs non-Asians(κ = 0.86 vs 0.35;P < 0.001).Combined FS/TE had 97% accuracy in Asians(n = 33).Baseline FS(0.38 vs 0.51,P < 0.001)and TE(8.0 kPa vs 11.9 kPa,P = 0.006)scores were lower in patients with sustained virological response than in nonresponders,and were maintained through follow-up.CONCLUSION:FS and TE may reliably differentiate mild from moderate-advanced disease,with a potential for high diagnostic accuracy in Asians with chronic HCV. | Keyur Patel Mireen Friedrich-Rust Yoav Lurie Mircea Grigorescu Carol Stanciu Chuan-Mo Lee Eugene R Schiff Dieter Hussinger Michael P Manns Guido Gerken Isabelle Colle Michael Torbenson Erik Pulkstenis G Mani Subramanian John G McHutchison Stefan Zeuzem | 2011 | World Journal of Gastroenterology2011，17，41： | 4 |
| 3 | Neoadjuvant peptide receptor radionuclide therapy for an inoperable neuroendocrine pancreatic tumor显示文摘Pancreatic endocrine tumors are rare but are among the most common neuroendocrine neoplasms of the abdomen.At diagnosis many of them are already advanced and diff icult to treat.We report on an initially inoperable malignant pancreatic endocrine tumor in a 33-year-old woman,who received neoadjuvant peptide receptor radionuclide therapy(PRRT)as firstline treatment.This resulted in a signif icant downstaging of the tumor and allowed its subsequent complete surgical removal.Follow-up for eighteen months revealed a complete remission.This is the first report on neoadjuvant PRRT in a neuroendocrine neoplasm with subsequent successful complete resection. | Daniel Kaemmerer Vikas Prasad Wolfgang Daffner Dieter Hrsch Günter Klppel Merten Hommann Richard P Baum | 2009 | World Journal of Gastroenterology2009，15，46： | 2 |
| 4 | Osmotic and oxidative/nitrosative stress in ammonia toxicity and hepatic encephalopathy显示文摘 | Boris G?rg Freimut Schliess Dieter H?ussinger | 2013 | Archives of Biochemistry and Biophysics2013，，2： | 2 |
| 5 | Mucin and phospholipids determine viscosity of gallbladder bile in patients with gallstones显示文摘AIM An increased viscosity of gallbladder bile has been considered an important factor in the pathogenesis of gallstone disease. Besides lipids and proteins, mucin has been suggested to affect the viscosity of bile. To further clarify these issues we compared mucin, protein and the lipid components of hepatic and gallbladder bile and its viscosity in patients with gallstones.METHODS Viscosity of bile ( mpa. s ) wasmeasured using rotation viscosimetry in regard to the non-Newtonian property of bile at law shear rates.RESULTS Biliary viscosity was markedly higher in gallbladder bile of patients with cholesterol (5.00 ± 0.60 mpa. s, mean ± SEM, n --28) and mixed stones (3.50±0.68 mPa. s; n =8) compared to hepatic bile (0.92 ± 0.06 mpa. s,n -6). A positive correlation between mucin and viscosity was found in gallbladder biles (r=0.65; P<0.001) but not in hepatic biles. The addition of physiologic and supraphysiologic amounts of mucin to gallbladder bile resulted in a dose dependent non linear increase of its viscosity. A positive correlation was determined between phospholipid concentration and viscosity (r = 0.34, P<0.005) in gallbladder biles. However, no correlation was found between total protein or the other lipid concentrations and viscosity in both gallbladder and hepatic biles.CONCLUSION The viscosity of gallbladder bile is markedly higher than that of hepatic bile in patients with gallstones. The concentration of mucin is the major determinant of biliary viscosity and may contribute by this mechanism to the role of mucin in the pathogenesis of gallstones. | Dieter Jüngst Anna Niemeyer Iris Müller Benedikta Zündt Günther Meyer Martin Wilhelmi Reginalddel Pozo | 2001 | World Journal of Gastroenterology2001，7，2： | 2 |
| 6 | SPQD14120800011178显示文摘 | Kordes Claus Sawitza Iris G?tze Silke Herebian Diran H?ussinger Dieter | 2014 | Journal of Clinical Investigation2014，，12： | 2 |
| 7 | Nanocrystalline diamond films显示文摘 | | 1999 | Annu Rev Mater Sci1999，，29： | 1 |
| 8 | Acetylation as a Transcriptional Control Mechanism—HDACs and HATs in Pancreatic Ductal Adenocarcinoma显示文摘 | Günter Schneider Oliver H. Kr?mer Roland M. Schmid Dieter Saur | 2011 | Journal of Gastrointestinal Cancer2011，，： | 1 |
| 9 | Genetic parameter estimates for volume from full - sib tests of slash pine 显示文摘 | M J Dieters T L White G R Hodge | 1995 | Can J For Res1995，25，8： | 1 |
| 10 | Biomechanical testing of the LCP-how can stability in locked internal fixators be controlled?显示文摘 | Stoffel K Dieter U Stachowiak G | 2003 | Injury2003，，342： | 1 |
| 11 | Lactonamyein Z,an antibiotic and antitunaor compound produced by Streptomyces sanglieri strain AK 623 显示文摘 | Holtzel A Dieter A Schmid D G | 2003 | J Antibiot2003，56，12： | 1 |
| 12 | Biomeehanical testing of the LCP- how can stability in locked internal fixators be controlled? 显示文摘 | Stoffel K Dieter U Staehowiak G | 2003 | Injury2003，342，： | 1 |
| 13 | Formation of sequences of cemented layers and hardpans within sulfide - bearing mine tailings显示文摘 | Torsten G Andrea K Dieter R | 2007 | Applied Geochemistry2007，22，1： | 1 |
| 14 | Determination of glutathione and glutathione disulphide in lichens: a comparison of frequently used methods显示文摘 | Ilse K Dieter G | 1996 | Phytochem Anal1996，，7： | 1 |
| 15 | Chromophores in porous silicas and minerals:preparation and optical properties显示文摘 | Günter Schulz-Ekloff Dieter Wohrle Bast van Duffel | 2002 | Microporous and Mesoporous Materials2002，51，2： | 1 |
| 16 | Biomechanical testing of the LCP:how can stability in locked internal fixators be controlled显示文摘 | Stoffel K Dieter U Stachowiak G | | 0，，02： | 1 |
| 17 | Asystematic tool for the minimization of the life cycle impactof solar assisted absorption cooling systems 显示文摘 | Berhane H G Gonzalo G G Laureano J Dieter B | 2010 | Energy2010，35，9： | 1 |
| 18 | Biomechanical testion of the LCP-How can stability in locked internal fixators be controlled 显示文摘 | Stpffel K Dieter U Stachowiak G | 2003 | Injury2003，，34： | 1 |
| 19 | Biomeehanical testing of the LCP-how can stability in locked internal fixators be controlled? 显示文摘 | Stoffel K Dieter U Stachowiak G | 2003 | Injury2003，34，2： | 1 |
| 20 | Biomechanical testing of the LCP how can stability in locking internal fixators be controlled显示文摘 | STOFFEL K DIETER U STACHOWIAK G | 2003 | Injury2003，2，： | 1 |
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