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| 1 | Proton nuclear magnetic resonance-based metabonomic models for non-invasive diagnosis of liver fibrosis in chronic hepatitis C:Optimizing the classification of intermediate fibrosis显示文摘AIM To develop metabonomic models(MMs), using 1 H nuclear magnetic resonance(NMR) spectra of serum, to predict significant liver fibrosis(SF: Metavir ≥ F2), advanced liver fibrosis(AF: METAVIR ≥ F3) and cirrhosis(C: METAVIR = F4 or clinical cirrhosis) in chronic hepatitis C(CHC) patients. Additionally, to compare the accuracy of the MMs with the aspartate aminotransferase to platelet ratio index(APRI) and fibrosis index based on four factors(FIB-4). METHODS Sixty-nine patients who had undergone biopsy in the previous 12 mo or had clinical cirrhosis were included. The presence of any other liver disease was a criterion for exclusion. The MMs, constructed using partial least squares discriminant analysis and linear discriminant analysis formalisms, were tested by cross-validation, considering SF, AF and C. RESULTS Results showed that forty-two patients(61%) presented SF, 28(40%) AF and 18(26%) C. The MMs showed sensitivity and specificity of 97.6% and 92.6% to predict SF; 96.4% and 95.1% to predict AF; and 100% and 98.0% to predict C. Besides that, the MMs correctly classified all 27(39.7%) and 25(38.8%) patients with intermediate values of APRI and FIB-4, respectively. CONCLUSION The metabonomic strategy performed excellently in predicting significant and advanced liver fibrosis in CHC patients, including those in the gray zone of APRI and FIB-4, which may contribute to reducing the need for these patients to undergo liver biopsy. | Andrea Dória Batista Carlos Jonnatan Pimentel Barros Tássia Brena Barroso Carneiro Costa Michele Maria Goncalves de Godoy Ronaldo Dionísio Silva Joelma Carvalho Santos Mariana Montenegro de Melo Lira Norma ThoméJucá Edmundo Pessoa de Almeida Lopes Ricardo Oliveira Silva | 2018 | World Journal of Hepatology2018，10，1： | 2 |
| 2 | Dy- namical compensation for time-delay systems: an LMI approach 显示文摘 | IVANESCU D DION J M DUGARD L | 2000 | International Journal of Robust and Nonlinear Control2000，10，8： | 1 |
| 3 | Treatment completion and costs of a randomized trial of rifampin for 4 months versus isoniazid for 9 months显示文摘 | Menzies D Dion M J Rabinovitch B | 2004 | Am J Respir Crit Care Med2004，170，： | 1 |
| 4 | TG1050,an immunotherapeutic to treat chronic hepatitis B,induces robust T cells and exerts an antiviral effect in HBVpersistent mice显示文摘 | Martin P Dubois C Jacquier E Dion S ManciniBourgine M Godon O Kratzer R Lelu-Santolaria K Evlachev A Meritet J F Schlesinger Y Villeval D Strub J M Van Dorsselaer A Marchand J B Geist M Brandely R Findeli A Boukhebza H Menguy T Silvestre N Michel M L InchauspéG | 2015 | Gut2015，64，12： | 1 |
| 5 | Ventilation during laparoscopic-assisted bariatric surgery: volume- controlled, pressure-controll-ed or volume-guaranteed pressure-regulated modes 显示文摘 | DION J M MCKEE C TOBIAS J D | 2014 | Int Clin Exp Med2014，7，8： | 1 |
| 6 | Rapid detection of Salmonella subspecies I by PCR combined with non-radioactive hybridization using covalently immobilized oligonucleotide on a microplate显示文摘 | CHEVIER D PROPOFF M Y DION M P | 1995 | FEMS Immunol Med Microbiol1995，10，34： | 1 |
| 7 | Sen- sor classification for the fault detection and isolation, a structural approach 显示文摘 | COMMAULT C DION J M TRINH D H | 2011 | International Joarnai of Adap- tive Control and Signal Processing2011，25，1： | 1 |
| 8 | Epidemiology of interstitial lung disease显示文摘 | Valeyve D Freynet O Dion G | 2010 | Presse Med2010，39，1： | 1 |
| 9 | A new,simple and accurate method for determining ejection fraction by Doppler echocardiography 显示文摘 | Dumesnil JG Dion D Yvorchuk K | 1995 | Can J Cardiol1995，11，： | 1 |
| 10 | Long-term clinical and angiographic follow-up of sequential internal thoracic artery grafting显示文摘 | Dion R Glineur D Derouck D | | 0，，： | 1 |
| 11 | Complementary saphenous grafting, long-term follow-up 显示文摘 | Dion R Glineur D Derouek D | 2001 | J Thorae Cardiovase Surg2001，122，： | 1 |
| 12 | Stability and robust stability of time-delay systems显示文摘 | Niculescu S I Verrist E I Dugard L Dion J D | 1997 | Aguided tour:in stability and control of time delay systems L Dugard E I Verrist Eds London U K:Springerverlay1997，1228，： | 1 |
| 13 | Light-harvesting complex gene expression is controlled by both transcriptional and post-transcriptional mechanisms during photoacclimation in Chlamydomonas reinhardtii显示文摘 | Dion G D Julie A P | 2003 | Physiol Plant2003，118，： | 1 |
| 14 | The further evolution of cooperation显示文摘 | Axelord R Dion D | 1988 | Science1988，12，： | 1 |
| 15 | Light-harvesting complex gene expression is controlled by both transcriptional and post- transcriptional mechanisms during photoacclimation in Chlamydomonas reinhardtii 显示文摘 | Dion G D Julie A P | 2003 | Physiologia Plantarum2003，118，2： | 1 |
| 16 | Van der Waals density functional theory with applications显示文摘 | LANGRETH D DION M RYDBERG H | 2005 | International Journal of Quan- tum Chemistry2005，101，5： | 1 |
| 17 | P5L mutation in Ank results in an increase in extracel ular inorganic pyrophosphate during proliferation and nonmineralizing hypertrophy in stably transduced ATDC5 cel s显示文摘 | Zaka R Stokes D Dion AS | | 0，，06： | 1 |
| 18 | Management of chronic neuro- pathic pain with methadone: a review of 13 cases显示文摘 | Altier N Dion D Boulanger A | 2005 | Clin J Pain2005，21，： | 1 |
| 19 | The further evolution oftrust显示文摘 | | 1988 | Science1988，，242： | 1 |
| 20 | Dynamical compensation for time-delay systems:An LMI Approach显示文摘 | Ivnescu D Dion J M Dugard L Niculescu S I | 2000 | International Journal of Robust and Nonlinear Control2000，10，8： | 1 |
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