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| 1 | Disease control with sunitinib in advanced intrahepatic cholangiocarcinoma resistant to gemcitabine-oxaliplatin chemotherapy显示文摘Advanced cholangiocarcinoma is associated with poor prognostic survival and has limited therapeutic options available at present. The importance of angiogenesis and expression of pro-angiogenic factors in intrahepatic forms of cholangiocarcinoma suggest that therapies targeting angiogenesis might be useful for the treatment of this disease. Here we report three cases of patients with advanced intrahepatic cholangiocarcinoma progressive after standard chemotherapy and treated with sunitinib 50 mg/d in 6-wk cycles of 4 wk on treatment followed by 2 wk off treatment(Schedule 4/2). In all three patients, sunitinib treatment was associated with a sustained disease control superior to 4 mo, patients achieving either a partial response or stable disease. A reduction in tumor size and density was observed in all cases, suggesting tumor necrosis as a result of sunitinib treatment in these patients. In addition, sunitinib was generally well tolerated and the occurrence of side effects was managed with standard medical interventions, as required. Our results suggest that sunitinib therapy maybe associated with favorable outcomes and tolerability in patients with advanced cholangiocarcinoma. Those observations contributed to launch a prospective phase Ⅱ multicenter trial investigating sunitinib in advanced intrahepatic cholangiocarcinoma(SUN-CK study; NCT01718327). | Chantal Dreyer Marie-Paule Sablin Mohamed Bouattour Cindy Neuzillet Maxime Ronot Safi Dokmak Jacques Belghiti Nathalie Guedj Valérie Paradis Eric Raymond Sandrine Faivre | 2015 | World Journal of Hepatology2015，7，6： | 4 |
| 2 | Rise of sodium-glucose cotransporter 2 inhibitors in the management of nonalcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease in the Western world. It is more prevalent in male gender, and with increasing age, obesity, and insulin resistance. Besides weight loss, there are limited treatment options. The use of anti-diabetic medications has been studied with mixed results. In this review, we discuss the use of anti-diabetic medications in the management of NAFLD with a specific focus on sodium-glucose cotransporter 2 inhibitors. We shed light on the evidence supporting their use in detail and discuss limitations and future directions. | Amr Dokmak Mohammad Almeqdadi Hirsh Trivedi Sandeep Krishnan | 2019 | World Journal of Hepatology2019，11，7： | 3 |
| 3 | Right Portal Vein Ligation is as Efficient as Portal Vein Embolization to Induce Hypertrophy of the Left Liver Remnant显示文摘 | B. Aussilhou M. Lesurtel A. Sauvanet O. Farges S. Dokmak N. Goasguen A. Sibert V. Vilgrain J. Belghiti | 2008 | Journal of Gastrointestinal Surgery2008，，2： | 2 |
| 4 | Selective Policy of No Drain after Pancreaticoduodenectomy Is a Valid Option in Patients at Low Risk of Pancreatic Fistula: A Case-Control Analysis显示文摘 | Chetana Lim Safi Dokmak Fran?ois Cauchy Beatrice Aussilhou Jacques Belghiti Alain Sauvanet | 2013 | World Journal of Surgery2013，，5： | 2 |
| 5 | Laparoscopic resection of hepatocellular carcinoma: a F rench survey in 351 patients显示文摘 | Olivier Soubrane Claire Goumard Alexis Laurent Hadrien Tranchart Stéphanie Truant Brice Gayet Chadi Salloum Guillaume Luc Safi Dokmak Tullio Piardi Daniel Cherqui Ibrahim Dagher Emmanuel Boleslawski Eric Vibert Antonio Sa Cunha Jacques Belghiti Patrick Pe | 2014 | HPB2014，，4： | 2 |
| 6 | Laparoscopic left lateral resection is the gold standard for benign liver lesions: a case–control study显示文摘 | Safi Dokmak Vikram Raut Béatrice Aussilhou Fadhel Samir Ftériche Olivier Farges Alain Sauvanet Jacques Belghiti | 2014 | HPB2014，，2： | 2 |
| 7 | Which limits to the 'ALPPS' approach显示文摘 | Dokmak S Belghiti J | | 0，，03： | 1 |
| 8 | Malignant transformation of liver adenoma: an analysis of the literature显示文摘 | Farges O Dokmak S | 2010 | Dig Surg2010，27，1： | 1 |
| 9 | Liver transplantation andsplenic artery steal syndrome: the diagnosis should be estab-lished preoperatively 显示文摘 | Dokmak S Aussilhou B Belghiti J | 2013 | Liver Transpl2013，19，6： | 1 |
| 10 | The long term risk of malignancy in patients with branch duct intraductal papillary mucinous neoplasms of the pancreas显示文摘 | Wafaa Khannoussi Marie Pierre Vullierme Vinciane Rebours Frédérique Maire Olivia Hentic Alain Aubert Alain Sauvanet Safi Dokmak Anne Couvelard Pascal Hammel Philippe Ruszniewski Philippe Lévy | 2012 | Pancreatology2012，，3： | 1 |
| 11 | Binding Versus Conventional Pancreaticojejunostomy After Pancreaticoduodenectomy: A Case-Matched Study显示文摘 | Léon Maggiori Alain Sauvanet Ganesh Nagarajan Safi Dokmak Béatrice Aussilhou Jacques Belghiti | 2010 | Journal of Gastrointestinal Surgery2010，，9： | 1 |
| 12 | Which limits to the 'ALPPS' approach7 显示文摘 | Dokmak S Belghiti J | 2012 | Ann Surg2012，256，3： | 1 |
| 13 | Which limits to the 'ALPPS' approach显示文摘 | Dokmak S Belghiti J | | 0，，03： | 1 |
| 14 | A single-center surgical experience of 122 patients with single and multiple hepatocellular adenomas显示文摘 | Dokmak S Paradis V Vilgrain V | 2009 | Gastroenterology2009，137，5： | 1 |
| 15 | Which limits to the 'ALPPS' approach? 显示文摘 | Dokmak S Belghiti J | 2012 | AnnSurg2012，256，3： | 1 |
| 16 | Long‐term survival after hepatic and pulmonary resection of colorectal cancer metastases显示文摘 | Isabelle Sourrouille Pierre Mordant Léon Maggiori Safi Dokmak Guy Lesèche Yves Panis Jacques Belghiti Yves Castier | 2013 | J Surg Oncol2013，，4： | 1 |
| 17 | A single-center surgi- cal experience of 122 patienls with single and multiple hepato- cellular adenonms 显示文摘 | Dokmak S Paradis V Vilgrain V | 2009 | Gastroenterology2009，137，5： | 1 |
| 18 | Changing trends in ma- lignant transformation of hepatocellular adenoma 显示文摘 | Farges O Ferreira N Dokmak S | 2011 | Gut2011，60，1： | 1 |
| 19 | Laparoscopic leftlateral resection is the gold standard for benign liver lesions: acase-control study显示文摘 | DOKMAK S RAUT V AUSSILHOU B | 2014 | HPB (Oxford)2014，16，2： | 1 |
| 20 | Changing trends in malig- nant transformation of hepatocellular adenoma 显示文摘 | Farges O Ferreira N Dokmak S | 2011 | Gut2011，60，： | 1 |
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