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| 1 | Long-term antifibrotic action of interferon-γ treatment in patients with chronic hepatitis B virus infection显示文摘BACKGROUND:The first priority in treating fibrosis is to eliminate the causes that result in liver injury,e.g.,hepatitis B and C virus.However,in many liver diseases the cause is either unknown or untreatable.The present study was designed to investigate the long-term antifibrotic effect of interferon-gamma(IFN-γ)treatment in patients chronically infected with hepatitis B virus. METHODS:A total of 42 patients,30 treated with IFN-γand 12 controls,were enrolled from an original clinical trial(Clin Gastroenterol Hepatol 2005;3:819.).Three serial liver biopsies that were obtained at the initiation and end of IFN-γtreatment as well as 4 to 6 years after treatment discontinuation were assessed according to the modified Chevallier scoring system. RESULTS:Twenty-five out of 30 IFN-γ-treated patients were followed up until 4 to 6 years after the treatment was stopped. However,all controls were excluded from follow-up due to death,loss and elevated virus level within 2 years.Twenty-five IFN-γ-treated patients had stable serum liver function and liver fibrosis indices without any further antiviral or anti-fibrotic treatment.Improved inflammatory and fibrotic scores were found after nine months of IFN-γtreatment according to the modified Chevallier scoring system(inflammation:11.8±6.5 at the beginning of IFN-γtreatment vs.9.2±4.1 after 9 months, P<0.05;fibrosis:15.0±7.3 at baseline vs.12.6±6.8 after 9 months, P<0.05).Among them,14 patients accepted a third serial liver biopsy 4 to 6 years after treatment discontinuation,and the fibrotic score was increased(14.2±8.3 vs.11.9±7.6 after 9 months, P<0.05). CONCLUSIONS:Nine-month IFN-γtreatment significantly improves the fibrosis score in patients with chronic HBV infection.The majority of patients demonstrate stable serum biochemical indices and quality of life.However,they do not show a long-term benefit according to histological criteria. Given the limited sample size,long-term IFN-γtreatment regimens should be assessed in further clinical trials. | Peter R Mertens Steven Dooley | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，2： | 6 |
| 2 | The cryogenic nitrogen automotive engine 显示文摘 | Dooley J Hammond R P | 1984 | Mechanical Engineering1984，，： | 1 |
| 3 | Attaining Decision Quality and Commitment from Dissent:The Moderating Effects of Loyalty and Competence in Strategic Decision Making Teams显示文摘 | Dooley R S Fryxell G E | 1999 | Academy of Management Journal1999，42，4： | 1 |
| 4 | An experimental study on the effect of polymer viscoelasticity on layers rearrangement in coextrusion structures显示文摘 | Dooley J Ramanathan R | 1998 | Polym Eng Sci1998，38，7： | 1 |
| 5 | The effect of fire on microbial biomass: a meta-analysis of field studies 显示文摘 | Dooley S R Treseder K K | 2012 | Biogeochemistry2012，109，13： | 1 |
| 6 | A review of the oxidation behavior of structural alloys in steam 显示文摘 | WRIGHT L G DOOLEY R B | 2010 | International Materials Reviews2010，55，3： | 1 |
| 7 | Attaining decision quality and commitment from dissent:The moderating effects of loyalty and competence in strategic decision-making teams显示文摘 | Dooley R S Fryxell G E | 1999 | Academy of Management Journal1999，42，4： | 1 |
| 8 | X-band holography显示文摘 | Dooley R P | 1965 | Proceedings of theIEEE1965，53，11： | 1 |
| 9 | 3D evolution of fold and thrust belts formed by oblique convergence 显示文摘 | McClay K R Whitehouse P S Dooley T | 2004 | Marine and Petroleum Geology2004，21，7： | 1 |
| 10 | 4-D evolution of rift systems:Insights from scaled physical models显示文摘 | McClay K R Dooley T Whitehouse P | 2002 | AAPG Bulletin2002，86，6： | 1 |
| 11 | A Preliminary Cost Curve Assessment of Carbon Dioxide Capture and Storage Potential in China 显示文摘 | R T Dahowski X Li CL Davidson N Wei JJ Dooley RH Gentile | 2009 | Energy Procedia2009，，1： | 1 |
| 12 | Diversity and repertoire of IgW and IgM VH families in the newborn nurse shark显示文摘 | Rumfelt L L Lohr R L Dooley H | 2004 | BMC Immunology2004，5，1： | 1 |
| 13 | Supply networks and complex adaptive systems:Control versus emergence显示文摘 | Chois T Y Dooley K J Manus R | 2001 | Journal of Operational Management2001，19，3： | 1 |
| 14 | Modeling the impacts of eli- mate policy on the deployment of carbon dioxide capture and geologic storage across electric power regions in the United States显示文摘 | Wise M Dooley J Dahowski R | 2007 | Int J Greenhouse Gas Control2007，1，2： | 1 |
| 15 | Strategic alliance outcomes: A transaction-cost economics perspective显示文摘 | Judge W Q Dooley R | 2006 | British Journal of Management2006，，17： | 1 |
| 16 | 4-D evolution of rift systems:Insights from scaled physical models显示文摘 | McClay K R Dooley T Whitehouse P | 2002 | AAPG Bulletin2002，86，6： | 1 |
| 17 | After the ink dries:the interaction of trust and control in US-basedinternational joint ventures 显示文摘 | Fryxell G E Dooley R S Vryza M | 2002 | Journal of ManagementStudies2002，39，6： | 1 |
| 18 | Platelet response to low-dose enteric-coated aspirin in patients with stable cardiovascular disease显示文摘 | Maree A O Curtin R J Dooley M | | 0，，07： | 1 |
| 19 | Pulsed Doppler echocardiographic determination of time of duetal closure in normal newborn infants显示文摘 | GENTILE R STEVENSON G DOOLEY T | 1981 | Pediatrics1981，98，3： | 1 |
| 20 | 3D evolution of fold and thrust belts formed by oblique convergence 显示文摘 | McClay K R Whitehouse P S Dooley T | 2004 | Marme and Petroleum Geology2004，21，： | 1 |
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