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| 1 | Disrupted regulatory T cell homeostasis in inflammatorybowel diseases显示文摘In the gut, where billions of non-self-antigens from the food and the microbiota are present, the immune response must be tightly regulated to ensure both host protection against pathogenic microorganisms and the absence of immune-related pathologies. It has been well documented that regulatory T cells(Tregs) play a pivotal role in this context. Indeed, Tregs are able to prevent excessive inflammation, which can lead to the rupture of intestinal homeostasis observed in inflammatory bowel diseases(IBDs). Both the worldwide incidence and prevalence of such diseases have increased throughout the latter part of the 20^(th) century. Therefore, it is crucial to understand how Tregs suppress the colitogenic immune cells to establish new treatments for patients suffering from IBDs. In this review, we will first summarize the results obtained in animal model studies that highlight the importance of Tregs in maintaining intestinal homeostasis and describe the specific suppressive mechanisms involved. Next, our current knowledge about Tregs contribution to human IBDs will be reviewed, as well as the current therapeutic perspective on using Tregs for clinical IBD treatment and the challenges that remain to be resolved to ensure both the safety and effectiveness of these therapies in targeting this critical immune-regulatory cell population. | Christophe Pedros Fanny Duguet Abdelhadi Saoudi Marianne Chabod | 2016 | World Journal of Gastroenterology2016，22，3： | 9 |
| 2 | Small dimension PDE for discrete Asian options显示文摘 | Benhamou E Duguet A | 2003 | Journal of Economic Dynamics & Control2003，27，： | 2 |
| 3 | Experimental study of ozone action on glycine显示文摘 | Duguet J P Jaulin L Aurelle Y | 1980 | Ozone Sci Eng1980，2，1： | 1 |
| 4 | How well do patent citations measure flows of technology? Evidence from French innovation surveys 显示文摘 | Duguet E and MacGarvie M | 2005 | Economics of Innovation and New Technology2005，14，5： | 1 |
| 5 | Kinetics of aqueousozone-induced oxidation of some endocrine disrupters显示文摘 | Deborde M Rabouan S Duguet J P | 2005 | Environmental Science and Technology2005，39，16： | 1 |
| 6 | Improvement in the effectiveness of ozonation of drinking water through the use of hydrogen peroxide显示文摘 | Duguet J P Brodard E Dussert B | 1985 | Ozone Sci Eng1985，7，2： | 1 |
| 7 | Estimating the innovation function from patent numbers:GMM on count panel data显示文摘 | Crépon B Duguet Emmanuel | 1997 | Journal of Applied Econometrics1997，12，3： | 1 |
| 8 | Comparison of magnetic and electrical phrenic nerve stimulation in assessment of phrenic nerve conduction time显示文摘 | Similowski T Mehiri S Duguet A | 1997 | J Appl hysiol1997，82，4： | 1 |
| 9 | Estimating the innovation function from patent numbers: GMM on count panel data 显示文摘 | Crepon B Duguet E | 1997 | Journal of Applied Econometrics1997，12，3： | 1 |
| 10 | Application of combined ozone hydrogenperoxide for the removal of aromatic compounds from groundwater 显示文摘 | Duguet J P Anselme C Mazounie P | 1990 | Ozone Science and Engineering1990，12，： | 1 |
| 11 | Research, Innovation And Productivi 显示文摘 | CREPON B DUGUET E MAIRESSEC J | 2006 | Economics of Innovation & New Technology2006，7，2： | 1 |
| 12 | Research, innovation and productivity: an econometric analysis at the firm level显示文摘 | CREPON B DUGUET E MAIRESSE J | 1998 | Economics of Innovation & New Technology1998，7，2： | 1 |
| 13 | How Well Do Pa-tent Citations Measure Knowledge Spillovers?Evi-dence from French Innovative Surveys显示文摘 | DUGUET E MACGARVIE M | 2005 | Econom-ics of Innovation and New Technology2005，14，5： | 1 |
| 14 | Research, Innovation and Productivity: An Econometric Analysis At The Firm Level 显示文摘 | Crepon B Duguet E Mairessec J | 1998 | Economics of Innovation and new Technology1998，7，2： | 1 |
| 15 | Are R&D subsidies a substitute or a comple- ment to privately funded R&D显示文摘 | DUGUET E | 2004 | Revued Economic Pol itique2004，114，2： | 1 |
| 16 | Occurrence ofmycobacteria in water treatment lines and in water distribution systems 显示文摘 | Le Dantec C Duguet JP Montiel A | 2002 | Appl Environ Microbiol2002，68，11： | 1 |
| 17 | J Mater Chem显示文摘 | Perro A Reculusa S Ravaine S Bourgeat-Lami E B Duguet E | 2005 | 15(35-36):3 7452005，15，3536： | 1 |
| 18 | A 200 -amino acid ATPase module in search of a basic function 显示文摘 | CONFALONIERI F DUGUET M | 1995 | Bioessays1995，17，7： | 1 |
| 19 | Minimizing bromate concentration by controlling the ozone reaction timein a full-scale plant显示文摘 | Bouland Sandrine Duguet Jean-Pierre Montiel Antoine | 2004 | Ozone : Science and Engineering2004，26，4： | 1 |
| 20 | Small dimension PDE for discrete Asian options显示文摘 | Benhamou E Duguet A | 2003 | Journal of Economic Dynamics & Control2003，，27： | 1 |
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