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| 1 | Role of hepatocyte nuclear factor 4-alpha in gastrointestinal and liver diseases显示文摘Hepatocyte nuclear factor 4-alpha(HNF4α)is a highly conserved member of nuclear receptor superfamily of ligand-dependent transcription factors that is expressed in liver and gastrointestinal organs(pancreas,stomach,and intestine).In liver,HNF4αis best known for its role as a master regulator of liver-specific gene expression and essential for adult and fetal liver function.Dysregulation of HNF4αexpression has been associated with many human diseases such as ulcerative colitis,colon cancer,maturity-onset diabetes of the young,liver cirrhosis,and hepatocellular carcinoma.However,the precise role of HNF4αin the etiology of these human pathogenesis is not well understood.Limited information is known about the role of HNF4αisoforms in liver and gastrointestinal disease progression.There is,therefore,a critical need to know how disruption of the expression of these isoforms may impact on disease progression and phenotypes.In this review,we will update our current understanding on the role of HNF4αin human liver and gastrointestinal diseases.We further provide additional information on possible use of HNF4αas a target for potential therapeutic approaches. | Matthew M Yeh Dustin E Bosch Sayed S Daoud | 2019 | World Journal of Gastroenterology2019，25，30： | 5 |
| 2 | Effects of inbreeding on survival and growth of Pacific white shrimp Penaeus (Litopenaeus) vannamei 显示文摘 | Dustin R Moss Steve M Arce Clete A Otoshi | 2007 | Aquaculture2007，2721，： | 1 |
| 3 | CX3CR1+ interstitial dendritic cells form a contiguous network throughout the entire kidney显示文摘 | Soos T J Sims T N Barisoni L Lin K Littman D R Dustin M L | 2006 | Kidney lnt2006，70，： | 1 |
| 4 | T cell receptor sig- naling precedes immunological synapse formation 显示文摘 | Lee K H Holdorf A D Dustin M L | 2002 | Science2002，295，5559： | 1 |
| 5 | Flying under the radar: the immunobiology of hepatitis C显示文摘 | Dustin L B Rice C M | 2007 | Annu Rev Immunol2007，25，： | 1 |
| 6 | ICAM-1 co-stimulates target cells to facilitate antigen presentation 显示文摘 | Lebedeva T Dustin M L Sykulev Y | 2005 | Curt Op in lmmunol2005，17，3： | 1 |
| 7 | The immunological synapse and the actin cytoskeleton:Molecular bardware for T cell signaling 显示文摘 | Dustin M L Cooper J A | 2000 | Nat Immunol2000，1，： | 1 |
| 8 | Alizapride in the prevention of post-thyroidectomy emetic sequelae显示文摘 | DEJONCKHEERE M DELOOF T DUSTIN N | 1990 | Eur J Anaesth1990，7，： | 1 |
| 9 | T cell receptor signaling precedes immunological synapse formation显示文摘 | Holdorf A D Dustin M L | 2002 | Science2002，295，5559： | 1 |
| 10 | Invasion by Toxoplasma gondii establishes a moving junction that selectively excludes host cell plasma membrane proteins on the basis of their membrane anchoring显示文摘 | Mordue DG Desai N Dustin M | 1999 | J Exp Med1999，190，12： | 1 |
| 11 | Invasion by Taxoplasma gondii establishes a moving unction that selectively exeludes host cell plasma membrane proteins on the basis of their membrane anchoring显示文摘 | Mordue DG Desai N Dustin M | 1999 | J Exp Med1999，190，12： | 1 |
| 12 | T Cell Activation:a Multidimensional Signaling Network显示文摘 | TSENG S Y DUSTIN M L | 2002 | Curr Opin Cell Biol2002，14，5： | 1 |
| 13 | Frequency of distinguishing clinical fea- tures in Vogt-Koyanagi-Harada disease显示文摘 | RAO NA GUPTA A DUSTIN L CHEE SP OKADA AA KHA- IRALLAH M | 2010 | Ophthalmology2010，117，3： | 1 |
| 14 | Malignancy risk for fine-needle aspiration of thyroid lesions according to the Bethesda System for Reporting Thyroid Cytopathology显示文摘 | Jo V Y Stelow E B Dustin S M | | 0，，24： | 1 |
| 15 | Induction by IL-1 and interferon-gamma:tissue distribution,biochemistry,and function a natural adherence molecule (ICAM-1)显示文摘 | DUSTIN M L ROTHLEIN R BHAN A K | 1986 | Journal of Immunology1986，137，1： | 1 |
| 16 | Classification of human motions using empirical mode decomposition of human micro-Doppler signatures显示文摘 | Dustin P and Narayanyan M | 2013 | IET Radar Sonar & Navigation2013，12，4： | 1 |
| 17 | The absence of plasma in ' spark plasma sintering' 显示文摘 | Dustin M Hulbert Andre Anders Dina V Dudina | 2008 | Journal of Applied Physics2008，104，3： | 1 |
| 18 | Induction by IL-1 and interferon-gamma:tissue distribution,biochemistry,and function of a natural adherence molecule (ICAM-1)显示文摘 | Dustin M L Rothlein R Bhan A K | 1986 | J Immunol1986，137，1： | 1 |
| 19 | Clones or no clones:genetic structure of riparian Populus euphratica forests in Central Asia显示文摘Many riparian(Tugai) forests growing along rivers in arid and hyper-arid regions of Central Asia are dominated by the Euphrates poplar(Populus euphratica). Besides generative reproduction, which is only possible upon flooding events and at a distance to the groundwater of less than 2 m, this phreatophytic tree species also reproduces vegetatively by forming clones that can cover land surface areas of several hectares. Along a gradient of groundwater distances, we investigated whether the fraction of clones in P. euphratica stands(1) increases with increasing distance to the water table;(2) is higher if supplied with water via river cut-offs; and(3) approaches 100% at a short distance to the groundwater, but at high salt concentrations in the upper soil layers, which would prevent germination and establishment of seedlings. AFLP(Amplified Fragment Length Polymorphism) analyses were conducted on leaf samples taken from mature P. euphratica trees growing at the fringes of the Taklimakan Desert in stands with different distances(2–12 m) to the groundwater at two plots at the middle and the lower reaches of the Tarim River and in a stand close to Ebinur Lake, Xinjiang, China. Genetic diversity was large among plots, but considerably smaller within plots. We found the highest genetic diversity(caused by regeneration from seeds) at plots that have a short distance to the groundwater or are supplied with additional water. There was no significant relationship between groundwater distance and clonal fraction. All investigated trees at the saline Ebinur Lake site belonged to one single clone. Our results demonstrate that the genetic pattern of this widespread species is not easily predictable even over small distances as it is a result of a complex interplay of stand history and dispersal of propagules(pollen, seeds, and vegetative diaspores) by wind and water. In conservation and restoration schemes, P. euphratica stands with a high genetic diversity and stands that grow at short distances to the water table and are regularly subjected to flooding(which favors generative over clonal reproduction) should be prioritized. | Katja KRAMP Thomas SCHMITT Petra LANG Michael JESCHKE Philipp SCHAFERI Dustin KULANEK ZHANG Ximing YU Ruide Frank M THOMAS | 2018 | Journal of Arid Land2018，10，5： | 1 |
| 20 | A supercode for inflammation显示文摘 | Dustin M | 2004 | Immunity2004，20，： | 1 |
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