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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | The structure of laccase protein and its synthesis by the commercial mushroom Agaricus bisporus显示文摘 | PERRY CR MATCHAM SE WOOD DA | 1993 | J Gen Microbiol1993，139，1： | 1 |
| 3 | Prospective comparison of laparoscopy,ultrasonography and computed tomography in the staging of gastric cancer显示文摘 | Carter CR Stewart I | 1996 | Br J Surg1996，83，： | 1 |
| 4 | The measurement of dyspnea,contents interobserver,agreement and physiological correlates of two new clinical indexes显示文摘 | Mahler DA Weinberg DH Wells CR | 1984 | Chest1984，85，6： | 1 |
| 5 | The effect of time,temperature and storage device on umbilical cord blood gas and lactate measurement: a randomized controlled trial显示文摘 | White CR Mok T Doherty DA | 2012 | J Matern Fetal Neonatal Med2012，25，6： | 1 |
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| 7 | Near- infrared reflectance spectroscopy-principal components regression analyses of soil properties显示文摘 | Chang CW Laird DA Mausbach MJ Hurburgh CR | 2001 | Soil Science Society of America Journal2001，，65： | 1 |
| 8 | Preparative isolation of triterpenoids from Ganoderma lucidum by counter-current chromatography combined with pH-zone-refining 显示文摘 | Cheng CR Li YF Xu PP Feng RH Yang M Guan SH Guo DA | 2012 | Food Chem2012，130，： | 1 |
| 9 | Early post-traumatic stress dis- order in relation to acute stress reaction: an ICD-10 study among help seekers fol- lowing an earthquake 显示文摘 | Soldatos CR Paparrigopoulos TJ Pappa DA | 2006 | PsyehiatryRes2006，143，23： | 1 |
| 10 | Helicobacter pylori eradication using tetracycline and furazolidone versus amoxicillin and azithromycin in lansoprazole based triple therapy:an open randomized clinical tria显示文摘 | Frota LC Da CMP Luz CR | 2005 | Arq Gastroenterol2005，42，2： | 1 |
| 11 | Intellectual im- pairment in children with blood lead concentrations below 10 ug per dec- iliter 显示文摘 | Canfield RL Henderson CR Jr Cory - Slechta DA | 2003 | N Engl J Med2003，348，： | 1 |
| 12 | Intellectual impairment in children with blood lead concentrations below 10 microg per deciliter显示文摘 | Canfield RL Henderson CR Jr Cory-Slechta DA | 2003 | N EngI J Med2003，348，16： | 1 |
| 13 | Intellectual impairment in children with blood lead concentrations below 10 microg per deciliter显示文摘 | Canfield RL Henderson CR Jr Cory - Slechta DA | 2003 | N Engl J Med2003，348，16： | 1 |
| 14 | Analysis of respiratory syncytial virus strain variation in successive epidemics in one city显示文摘 | Cane PA Matthews DA Pringle CR | 1994 | J Clin Microbiol1994，32，1： | 1 |
| 15 | Cytotoxic properties of eosinophil granule major basic protein for tumor cells 显示文摘 | Loegering DA Adolphson CR | 1999 | Int Arch Allergy Immunol1999，118，24： | 1 |
| 16 | FRNK blocks v-srcstimulated invasion and experimental metastases without effects on cell motility or growth显示文摘 | Hauck CR Hsia DA Puente XS | 2002 | EMBO2002，21，23： | 1 |
| 17 | Differential regulation of cell motility and invasion by FAK显示文摘 | Hsia DA Mitra SK Hauck CR | 2003 | J Cell Biol2003，160，5： | 1 |
| 18 | Biological conse-quences of ecosystem fragmentation:A review显示文摘 | Saunders DA Hobbs RJ Margules CR | | 0，，： | 1 |
| 19 | Critical role of IL-17RA in immunopathology of influenza infection 显示文摘 | Crowe CR Chen K Pociask DA | 2009 | Journal of Immunology2009，183，8： | 1 |
| 20 | Critical role of IL-17RA in immunopathology of influenza infection 显示文摘 | Crowe CR Chen K Pociask DA | 2009 | J Immunol2009，183，8： | 1 |
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