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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 3 | 顽固性高血压与由心内容积决定的血管内液体潴留无关显示文摘顽固性高血压(refractory hypertension,RfHTN)是一种极端的抗高血压治疗失败的表现形式,定义为使用了包括长效噻嗪类和盐皮质激素受体拮抗剂在内的≥5种药时血压仍控制欠佳。RfHTN是难治性高血压(resistant hypertension,RHTN)的一个亚组,RHTN定义为使用≥3种降压药(包括利尿剂)后血压仍〉135/85mm Hg(1mm Hg=0.133kPa)。 | 刘青 叶鹏 Velasco A Siddiqui M Kreps E Kolakalapudi P Dudenbostel T Arora G Judd EK Prabhu SD Lloyd SG Oparil S Calhoun DA | 2018 | 中华高血压杂志2018，26，7： | 2 |
| 4 | 年龄相关性线粒体功能障碍加速动脉粥样硬化形成显示文摘老化是动脉粥样硬化的最强危险因素之一。然而,老化是否独立于慢性高血脂症而增加动脉粥样硬化的风险尚不清楚。该研究旨在确定高血脂症诱导前的血管老化是否会加速动脉粥样硬化的形成。研究者分析了幼年和老年正常血脂野生型(wild type,WT)、无疾病小鼠的主动脉,发现老化导致白细胞介素(interleukin,IL)6水平升高和线粒体功能障碍,并与线粒体自噬增加和其相关蛋白Parkin增加相关。在主动脉组织培养中,研究者发现随着老化的出现,线粒体功能障碍与IL-6存在正反馈关系。研究者通过诱导低密度脂蛋白受体的肝脏特异性降解,再结合10周的西方食物喂养,在老年和幼年小鼠中诱发急性高血脂症,发现老年WT小鼠的动脉粥样硬化增强。高血脂症进一步降低了老年小鼠的线粒体功能,增加了主动脉中Parkin的水平,但幼鼠则没有。 | 刘青(译) 叶鹏(摘、审校) Tyrrell DJ Blin M Song J Wood S Zhang M Beard DA Goldstein D | 2020 | 中华高血压杂志2020，28，2： | 2 |
| 5 | Transmission capacity: availability, maximum, transfer and reliability显示文摘 | Leite da S A M de Carvalho C J G da Fonseca M L A | 2002 | IEEE Transactions on Power Systems2002，17，3： | 1 |
| 6 | Selective synthesis of glycerol monolaurate with zeolitic molecular sieves显示文摘 | M da S Machado J P6rez - Pariente E Sastre | 2000 | Applied Catalysis A : General2000，203，2： | 1 |
| 7 | Assessment of the clinical effectiveness of pulmonary artery catheters in management of patients in intensive care ( PAC-Man ) : a randomised controlled trial 显示文摘 | Harvey S Harrison DA Singer M | 2005 | Lancet2005，366，9484： | 1 |
| 8 | Multiloop edgewise archwire in the treatment of a patient with an anterior open bite and a long face显示文摘 | Ribeiro GL Regis S Jr da Cunha Tde M | 2010 | Am J Orthod Dentofacial Orthop2010，138，1： | 1 |
| 9 | Long-term probabilistic evaluation of operating reserve requirements with renewable sources显示文摘 | da SILVA A M L SALES W S da FONSECA MANSO L A | 2010 | IEEE Trans on Power Systems2010，25，1： | 1 |
| 10 | Unified Method for the Prediction of Rain Attenuation in Satellite and Terrestrial Links显示文摘 | DA SILVA MELLO L PONTES M S | 2012 | Journal of Microwaves Optoelectronics and Electromagnetic Applications2012，11，1： | 1 |
| 11 | Quantification of catechin and poranthocyanidins in several portuguese grapevine varieties and red wines 显示文摘 | Sun B S Ricardo da Silva J Mv Spranger M | 2001 | Ciencia E Tecnica Vitivinico- la2001，16，1： | 1 |
| 12 | Study of catalyst deactivation and reaction mechanism of steam reforming,partial oxidation,and oxidative steam reforming of ethanol over Co/CeO2 catalyst显示文摘 | de Lima S M da Silva A M da Costa L O O | 2009 | J Catal2009，268，2： | 1 |
| 13 | Parametric Study of Adhesive Joints with Composites 显示文摘 | NETO J A B P CAMPILHO R D S G DA SILVA L F M | 2012 | International Journal of Adhesion and Adhesives2012，，： | 1 |
| 14 | Impaired synaptic plasticity and motor learning in mice with a point mutation implicated in human speech deficits显示文摘 | Groszer M Keays DA Deacon RM de Bono JP Prasad-Muleare S Gaub S et at | | 0，，05： | 1 |
| 15 | The electronic properties of sputtered chromium and iron oxide films显示文摘 | G Goodlet S Faty S Cardoso P.P Freitas A.M.P Sim?es M.G.S Ferreira M Da Cunha Belo | 2003 | Corrosion Science2003，，6： | 1 |
| 16 | Chemical composition and free radical scavenging activity of pollen loadsfrom stingless bee Melipona subnitida D\icke显示文摘 | Silva T M S Camara C A da Silva Lins A C | 2006 | Journal of Food Composition and Analysis2006，19，6： | 1 |
| 17 | Prediction of rain attenuation in terrestrial links using full rainfall rate distribution显示文摘 | SILLVA MELLO DA L A R PONTES M S SOUZA DE R M | 2007 | Electronics Letters2007，43，25： | 1 |
| 18 | Enthalpies of combustion, vapour pressures, and enthalpies of sublimation of 8- hydroxyquinoline, 5-nitro-8-hydroxyquinoline, and 2-methyl-8-hydroxyquinoline显示文摘 | Ribeiro Da Silva M A V Monte M J S Matos M A R | 1989 | Chem Thermodyn1989，，21： | 1 |
| 19 | The Mycobacterium tuberculosis protein serine/threonine kinase PknG is linked to cellular glutamate/glutamine levels and is important for growth in vivo显示文摘 | Cowley S Ko M Pick N Chow R Downing KJ Gordhan BG Betts JC Mizrahi V Smith DA Stokes RW Av-Gay Y | 2004 | Mol Microbiol2004，52，6： | 1 |
| 20 | RGD-dependent linkage between plant cell wall and plasma membrane:consequences for growth显示文摘 | Schindler M Meiners S Cheresh DA | 1989 | J Cell Biol1989，108，： | 1 |
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