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| 1 | Vascular endothelial growth factor for the treatment of femoral head osteonecrosis: An experimental study in canines显示文摘AIM To evaluate the treatment of osteonecrosis of the femoral head(ONFH) with the use of vascular endothelial growth factor(VEGF).METHODS In 30 mature beagles(6 groups of 5 beagles) ONFH was induced cryosurgically and one of the following solutions was administered locally in the femoral head(FH) in each group: Single injection of 500 μg VEGF(t-VEGFμ group); single injection of 500 ng VEGF(t-VEGFn group); continuous delivery of 500 μg VEGF through osmotic micropump(t-VEGFpump-μ group); continuous delivery of 500 ng VEGF through osmotic micropump(t-VEGFpump-n group); single injection of 0.9% sodium chloride(t-NS group), while one group that served as control group did not receive any local solution(No-t group). FHs were retrieved 12 wk postoperatively, underwent decalcification and hematoxylin/eosin and toluidine blue staining. In two canines per group, one half of FH was processed without decalcification and stained with modified Masson Trichrome. Histological sections were observed by light microscopy and measured with a semi-automatized bone histomorphometry system and Bone Volume/Total Volume(BV/TV), Marrow Volume/Total Volume(MaV/TV), and Trabecular Thickness(TbT h) were assessed. Standard and robust tests(Welch, Brown Forsythe) of analysis of variance along with multiple comparisons, were carried out among the categories.RESULTS The untreated(No-t) group had signs of osteonecrosis, whereas the VEGF groups revealed reversal of the osteonecrosis. Statistical analysis of the decalcified specimens revealed a significantly better BV/TV ratio and a higher Tb Th between the VEGF treatment groups(except the t-VEGFn group) and the No-t group or the control t-NS group. Single dose 500 μg VEGF group had significantly better BV/TV ratio and higher Tb Th when compared to the No-t group(50.45 ± 6.18 vs 29.50 ± 12.27, P = 0.002 and 151.44 ± 19.07 vs 107.77 ± 35.15, P = 0.161 respectively) and the control t-NS group(50.45 ± 6.18 vs 30.9 ± 6.67, P = 0.004 and 151.44 ± 19.07 vs 107.14 ± 35.71, P = 0.151 respectively). Similar differences were found for the prolonged VEGF delivery/pump groups of 500 μg and 500 ng. Analysis of the totality of specimens(decalcified/non-decalcified) enhanced the aforementioned differences and additionally revealed significant differences in the comparison of the TbT h.CONCLUSION In an experimental model of ONFH in canines it was found that local treatment with VEGF leads to bone tissue remodeling and new bone formation. | Zoe H Dailiana Nikolaos Stefanou Lubna Khaldi Georgios Dimakopoulos James R Bowers Cristian Fink James R Urbaniak | 2018 | World Journal of Orthopedics2018，9，9： | 13 |
| 2 | Heterotopic ossification after the use of recombinant human bone morphogenetic protein-7显示文摘AIM To present the incidence of heterotopic ossification after the use of recombinant human bone morphogenetic protein-7(rhB MP-7) for the treatment of nonunions.METHODS Bone morphogenetic proteins(BMPs) promote bone formation by auto-induction. Recombinant human BMP-7 in combination with bone grafts was used in 84 patients for the treatment of long bone nonunions. All patients were evaluated radiographicaly for the development of heterotopic ossification during the standard assessment for the nonunion healing. In all patients(80.9%) with radiographic signs of heterotopic ossification, a CT scan was performed. Nonunion site palpation and ROM evaluation of the adjacent jointswere also carried out. Factors related to the patient(age, gender), the nonunion(location, size, chronicity, number of previous procedures, infection, surrounding tissues condition) and the surgical procedure(graft and fixation type, amount of rhB MP-7) were correlated with the development of heterotopic ossification and statistical analysis with Pearsons χ~2 test was performed.RESULTS Eighty point nine percent of the nonunions treated with rh BMP-7, healed with no need for further procedures. Heterotopic bone formation occurred in 15 of 84 patients(17.8%) and it was apparent in the routine radiologi-cal evaluation of the nonunion site, in a mean time of 5.5 mo after the rh BMP-7 application(range 3-12). The heterotopic ossification was located at the femur in 8 cases, at the tibia in 6, and at the humerus in οne patient. In 4 patients a palpable mass was present and only in one patient, with a para-articular knee nonunion treated with rhB MP-7, the size of heterotopic ossification affected the knee range of motion. All the patients with heterotopic ossification were male. Statistical analysis proved that patient's gender was the only important factor for the development of heterotopic ossification(P = 0.007). CONCLUSION Heterotopic ossification after the use of rh BMP-7 in nonunions was common but it did not compromise the final clinical outcome in most cases, and affected only male patients. | Marianthi Papanagiotou Zoe H Dailiana Theophilos Karachalios Sokratis Varitimidis Michael Hantes Georgios Dimakopoulos Marianna Vlychou Konstantinos N Malizos | 2017 | World Journal of Orthopedics2017，8，1： | 3 |
| 3 | Drug therapy increases bone density in osteonecrosis of the femoral head in canines 显示文摘 | Bowers JR Dailiana ZH McCarthy EF | 2004 | J Surg Orthop Adv2004，13，4： | 1 |
| 4 | Expres- sion profile of osteoprotegerin,RANK and RANKL genes in the femoral head of patients with avascular necrosis显示文摘 | SAMARA S DAILIANA Z CHASSANIDIS C | 2014 | Exp Mol Pathol2014，96，1： | 1 |
| 5 | Treatment of intra - articular fractures of the distal radius:fluoroscopic or arthroscopic reduction 显示文摘 | Varitimidis SE Basdekis GK Dailiana ZH | 2008 | J Bone Joint Surg Br2008，6，： | 1 |
| 6 | Treatment of intra-articular fractures of the distal radius:fluoroscopic or arthroscopic reduction?显示文摘 | Varitimidis SE Basdekis GK Dailiana ZH | 2008 | J Bone Joint Surg Br2008，90，6： | 1 |
| 7 | Effect of clopidogrel in bone healing-experimental study in rabbits显示文摘BACKGROUND Clopidogrel is a widely prescribed drug for prevention of myocardial infarction and stroke in patients at risk.It inhibits thrombus formation via inhibition of the P2Y12 purinergic receptor on platelets,which is important in their activation by ADP.However,the P2Y12 receptor has also been found to be expressed in both osteoblasts and osteoclasts.Accumulated evidence suggests that purinergic receptors regulate important functions of bone turnover.Previous studies on the effect of clopidogrel on bone metabolism indicated potential harmful effects,but their results remain conflicting.Thus,clopidogrel treatment may affect bone healing,but it has not yet been studied.AIM To evaluate if continuous perioperative clopidogrel treatment has any negative effect on bone healing in the rabbit calvarial defect model.METHODS Sixteen male white New Zealand rabbits were randomly assigned in two groups:One group received daily 3 mg/kg of clopidogrel per os and the other group received the vehicle alone for a week prior to the surgical procedures;the treatments were continued for another 6 wk postoperatively.The surgical procedures included generation of two circular calvarial defects 11 mm in diameter in every animal.After the 6-wk period of healing,postmortem radiographic and histomorphometric evaluation of the defects was performed.RESULTS Both the surgical procedures and the postoperative period were uneventful and well tolerated by all the animals,without any surgical wound dehiscence,signs of infection or other complication.New bone was formed either inwards from the defect margins or in the central portion of the defect as separated bony islets.While defect healing was still incomplete in both groups,the clopidogrel group had significantly improved radiographic healing scores.Moreover,the histomorphometric analysis showed that bone regeneration(%)was 28.07±7.7 for the clopidogrel group and 19.47±4.9 for the control group,showing a statistically significant difference between them(P=0.018).Statistically significant difference was also found in the defect bridging(%),i.e.72.17±21.2 for the clopidogrel group and 41.17±8.5 for the control group,respectively(P=0.004),whereas there was no statistical difference in bone tissue density between the groups.CONCLUSION Our results indicate that maintenance of perioperative clopidogrel treatment does not negatively affect bone healing but rather promotes it.Further research is needed in order to find useful applications of this finding. | Theodoros Lillis Alexander Veis Nikolaos Sakellaridis Anastasios Tsirlis Zoe Dailiana | 2019 | World Journal of Orthopedics2019，10，12： | 1 |
| 8 | Glomus tumor of the nail area显示文摘 | Foucher C Le Viet Dailiana Z | 1999 | Rew Chit Orthop Reparatrice Appor Mot1999，85，4： | 1 |
| 9 | Submillimeterresolution MR of the endolymphatie sac in healthy subjects and patients with Meniere disease 显示文摘 | Sehmalbrock P Dailiana T Chakeres DW | 1996 | AJNR1996，17，9： | 1 |
| 10 | Purulent flexor tenosynovitis:factors influencing the functional outcome 显示文摘 | Dailiana ZH Rigopoulos N Varitimidis S | 2008 | J Hand Surg Enr Vol2008，33，3： | 1 |
| 11 | Drug therapy increases bone density in osteonecrosis of the femoral head in canines显示文摘 | Bowers JR Dailiana ZH Mc Carthy EF Urbaniak JR | 2004 | J Surg Orthop Adv2004，13，4： | 1 |
| 12 | Treatment of intra - articular fractures of the distal radius:fluoroscopic or arthroscopic reduction显示文摘 | Varitimidis SE Basdekis GK Dailiana ZH | 2008 | J Bone Joint Surg Br2008，90，： | 1 |
| 13 | Injeetion injuries: seemingly minor injuries with major consequences显示文摘 | Dailiana 1-i Kotsaki D Varitimidis S et aI | 2008 | Hi- ppekratia2008，12，1： | 1 |
| 14 | MR imaging findings in transient osteoporosis of the hip显示文摘 | MALIZOS K N ZIBIS A H DAILIANA Z | 2004 | Eur J Radiol2004，50，3： | 1 |
| 15 | Relapsed clubfoot correction with soft-tissue release and selective application of Ilizarov technique显示文摘 | Malizos KN Gougoulias NE Dailiana ZH | 2008 | Strategies Trauma Limb Reconstr2008，3，3： | 1 |
| 16 | Longstanding nonunions of scaphoid fractures with bone loss successful reconstruction with vascularized bone grafts 显示文摘 | Malizos KN Dailiana ZH Kirou M | 2001 | J Hand Surg [ Br]2001，26，4： | 1 |
| 17 | Type specific prevalence of genital human papillomavirus in benign,premalignant,and malignant biopsies in patients from Greece显示文摘 | Diakomanolis E Dailianas S | 1997 | Sex Trans Dis1997，24，： | 1 |
| 18 | Compartmental infections of the hand显示文摘 | Rigopoulos N Dailiana ZH Varitimidis S | 2008 | Seand J Plast Reconstr Surg Hand Surg2008，42，1： | 1 |
| 19 | Drug therapy increases bone density in osteonecrosis of the femoral head in canines显示文摘 | Bowers JR Dailiana ZH McCarthy EF | 2004 | Surg Orthop Adv2004，13，4： | 1 |
| 20 | The role of MR imaging in scaphoid disorders显示文摘 | Karantanas A Dailiana Z Malizos K | 2007 | Eur Radiol2007，17，11： | 1 |
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