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| 1 | Relationship between HER-2 overexpression and brain metastasis in esophageal cancer patients显示文摘AIM:To study if HER-2 overexpression by locally advanced esophageal cancers increase the chance of brain metastasis following esophagectomy.METHODS:We retrospectively reviewed the medical records of esophageal cancer patients who underwent esophagectomy at University of Iowa Hospitals and Clinics between 2000 and 2010.Data analyzed consisted of demographic and clinical variables.The brain metastasis tissue was assayed for HER-2 overexpression utilizing the FDA approved DAKO Hercept Test.RESULTS:One hundred and forty two patients were reviewed.Median age was 64 years(36-86 years).Eighty eight patients(62%) received neoadjuvant chemoradiotherapy.Pathological complete and partial responses were achieved in 17(19%) and 71(81%) patients.Cancer relapsed in 43/142(30%) patients.The brain was the first site of relapse in 9/43 patients(21%,95% CI:10%-36%).HER-2 immunohistochemistry testing of the brain metastasis tissue showed that 5/9(56%) cases overexpressed HER-2(3+ staining).CONCLUSION:HER-2 overexpression might be associated with increased risk of brain metastasis in esophageal cancer patients following esophagectomy.Further studies will be required to validate this observation. | Taher Abu Hejleh Barry R DeYoung Eric Engelman Jeremy M Deutsch Bridget Zimmerman Thorvardur R Halfdanarson Daniel J Berg Kalpaj R Parekh William R Lynch Mark D Iannettoni Sudershan Bhatia Gerald Clamon | 2012 | World Journal of Gastrointestinal Oncology2012，4，5： | 5 |
| 2 | 面子研究的传承与嬗变显示文摘从历史演变到当下多视角的热议,面子研究呈现了历史传承性与嬗变性。本文主要从其概念衍生的历史渊源以及研究内容、手段的演变两个方面,对面子研究进行了详实的回溯。在此基础之上,本文从积极面子与消极面子划分之争、特定文化面子问题研究的不足、以及汉语文化特性面子研究的必要性三个方面进行概述,并提出未来研究的新议题、新思路。 | 周凌 Daniel Kádár | 2016 | 外语研究2016，33，3： | 4 |
| 3 | Coexpression of receptor-tyrosine-kinases in gastric adenocarcinoma-a rationale for a molecular targeting strategy?显示文摘AIM: To define the (co-)expression pattern of target receptor-tyrosine-kinases (RTK) in human gastric adenocarcinoma. METHODS: The (co-)expression pattern of VEGFR1-3,PDGFRα/b and EGFR1 was analyzed by RT-PCR in 51 human gastric adenocarcinomas. In addition,IHC staining was applied for confirmation of expression and analysis of RTK localisation. RESULTS: The majority of samples revealed a VEGFR1 (98%),VEGFR2 (80%),VEGFR3 (67%),PDGFRα (82%) and PDGFRβ(82%) expression,whereas only 62% exhibited an EGFR1 expression. 78% of cancers expressed at least four out of six RTKs. While VEGFR1-3 and PDGFRα revealed a predominantly cytoplasmatic staining in tumor cells,accompanied by an additional nuclear staining for VEGFR3 ,EGFR1 was almost exclusively detected on the membrane of tumor cells. PDGFRβ was restricted to stromal pericytes,which also depicted a PDGFRα expression.receptor-tyrosine-kinases coexpression in gastric adenocarcinoma and might therefore encourage an application of multiple-target RTK-inhibitors within a combination therapy. | Daniel Drescher Markus Moehler Ines Gockel Kirsten Frerichs Annett Müller Friedrich Dünschede Thomas Borschitz Stefan Biesterfeld Martin Holtmann Thomas Wehler Andreas Teufel Kerstin Herzer Thomas Fischer Martin R Berger Theodor Junginger Peter R Galle Carl C Schimanski | 2007 | World Journal of Gastroenterology2007，13，26： | 4 |
| 4 | 多重结局的多元Meta分析和多重治疗的网状Meta分析:原理、概念及实例显示文摘英国国家健康与临床优选研究所(NICE)等组织需要对现有研究获得的证据进行整合来指导决策,需要确定关于多重疗效及安全性结局的最佳治疗。但是,相关的研究不一定对所有关注的治疗或结局都进行了直接比较,多元Meta分析及网状Meta分析为如何确定最佳治疗这一问题提供了思路,该方法不仅考虑了直接证据,还利用了关联或间接的证据。本文中,研究者描述了这些方法学的重要概念及假设,并阐述关联及间接证据如何产生,同时通过图表说明这些证据在涉及多重结局和多重治疗的真实临床案例中如何使用。 | Richard D Riley Dan Jackson Georgia Salanti Danielle L Burke Malcolm Price Jamie Kirkham Ian R White 孙至佳(译) 张岩(译) 刘雪晴(译) 杨智荣(校) 孙凤(校) | 2018 | 英国医学杂志中文版2018，21，12： | 2 |
| 5 | Postpartum Subclinical Hypocalcaemia and Effects on Ovarian Function and Uterine Involution in a Dairy Herd 显示文摘 | Kamgarpour R C W Daniel D C Fenwick | 1999 | Vet J1999，158，： | 1 |
| 6 | Effect of chemical amendments on ammonia volatilization from poultry litter显示文摘 | Moore P A J Daniel T C Edwards D R | 1995 | Journal of Environmental Quality1995，24，： | 1 |
| 7 | Robust face recognition for uncontrolled pose and illumination chan- ges显示文摘 | Maria D M Michele N Daniel R | 2013 | 1EEE Transactions on Systems Man and Cy- bernetics: Systems2013，43，1： | 1 |
| 8 | Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2012-2013显示文摘 | Meijer A Rebelo-de-Andrade H Correia V Besselaar T Drager-Dayal R Fry A Gregory V Gubareva L Kageyama T Laekenby A Lo J Odagiri T Pere- yaslov D Siqueira M M Takashita E Tashiro M Wang D Wong S Zhang W Daniels R S Hurt A C | 2014 | An- tiviral Research2014，110，： | 1 |
| 9 | Are there better indices for evalu- ation purposes than the h index? A comparison of nine different variants of the h index using data from biomedicine 显示文摘 | Bornmann L Mutz R Daniel H D | 2008 | Journal of the Ameri- can Society for Information Science and Technology2008，59，5： | 1 |
| 10 | Experimental studies of pylon-aided fuel injection into a supersonic cross flow显示文摘 | Mark R Gruber Campell D Carter Daniel R Monters | 2008 | Journal of Aerospace Power2008，5，6： | 1 |
| 11 | Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B(9-23)显示文摘 | WEGMANN D R | 1996 | Proc Natl Acad Sci USA1996，93，2： | 1 |
| 12 | Wildlife damage to crops:perceptions of agricultural and wildlife professionals in 1957 and 1987显示文摘 | DANIEL J D | 1991 | Wildl Soc Bull1991，19，： | 1 |
| 13 | Activity of the neuronal cold sensor TRPM8 is regulated by phospholipase C via the phospholipid phospholnosltol 4, 5 bisphosphate 显示文摘 | Daniels R L Takashima Y McKemy D D | 2009 | J Biol Chem2009，284，： | 1 |
| 14 | Slope stability of geosynthetic clay liner test plots显示文摘 | Daniel D E Koerner R M Bonaparte R | 1998 | J Geotech Geoenviron Eng1998，124，7： | 1 |
| 15 | 显示文摘 | Mai Q X Daniels R D Harpalani H B | 1988 | Thin Solid Films1988，166，： | 1 |
| 16 | Conceptual modeling as a toolbox for grounded theorists 显示文摘 | Danielle S Britt D Maines D R | 2001 | The Sociological Quarterly2001，42，： | 1 |
| 17 | Effectiveness of vegetative filter strips in controlling losses of surface-applied poultry litters constituents 显示文摘 | CHAUBEY I EDWARDS D R DANIEL T C | 1995 | Tran ASAE1995，38，6： | 1 |
| 18 | Combustion and emissions of 2,5-dimethylfuran in a direct-injection spark-Ignition engine 显示文摘 | DANIEL R XU H M TURNER D | 2010 | Energy Fuels2010，24，5： | 1 |
| 19 | Core-shell nanostructured nanoparticle films as chemically sensitive interfaces显示文摘 | Li H Daniel R D Maye M M | 2001 | Anal Chem2001，73，10： | 1 |
| 20 | Cloning and sequencing of a full length cDNA encoding ovine lipoprotein lipase 显示文摘 | EDWARDS W D DANIELS S E PAGE R A | 1993 | Biochim Biophys Acta1993，1172，12： | 1 |
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