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| 1 | Prognostic value of pre-treatment F-18-FDG PET-CT in patients with hepatocellular carcinoma undergoing radioembolization显示文摘AIM To evaluate the value of pre-treatment 18F-FDG PET/CT in patients with HCC following liver radioembolization.METHODS We identified 34 patients with HCC who underwent an FDG PET/CT scan prior to hepatic radioembolization at our institution between 2009 and 2013. Patients wereseen in clinic one month after radioembolization and then at 2-3 mo intervals. We assessed the influence of FDG tumor uptake on outcomes including local liver control(LLC), distant liver control(DLC), time to distant metastases(DM), progression free survival(PFS) and overall survival(OS).RESULTS The majority of patients were males(n = 25, 74%), and had Child Pugh Class A(n = 31, 91%), with a median age of 68 years(46-84 years). FDG-avid disease was found in 19(56%) patients with SUVmax ranging from 3 to 20. Female patients were more likely to have an FDG-avid HCC(P = 0.02). Median follow up of patients following radioembolization was 12 months(1.2-62.8 mo). FDG-avid disease was associated with a decreased 1 year LLC, DLC, DM and PFS(P < 0.05). Using multivariate analysis, FDG avidity predicted for LLC, DLC, and PFS(all P < 0.05).CONCLUSION In this retrospective study, pre-treatment HCC FDGavidity was found to be associated with worse LLC, DLC, and PFS following radioembolization. Larger studies are needed to validate our initial findings to assess the role of F-18-FDG PET/CT scans as biomarker for patients with HCC following radioembolization. | Yazan Abuodeh Arash O Naghavi Kamran A Ahmed Puja S Venkat Youngchul Kim Bela Kis Junsung Choi Benjamin Biebel Jennifer Sweeney Daniel A Anaya Richard Kim Mokenge Malafa Jessica M Frakes Sarah E Hoffe Ghassan El-Haddad | 2016 | World Journal of Gastroenterology2016，22，47： | 3 |
| 2 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 3 | Antibiotic-loaded phosphatidylcholine inhibits staphylococcal bone infection显示文摘AIM: To test antibiotic-loaded coating for efficacy in reducing bacterial biofilm and development of osteomyelitis in an orthopaedic model of implant infection. METHODS: Phosphatidylcholine coatings loaded with 25% vancomycin were applied to washed and sterilized titanium wires 20 mm in length. A 10 mm segment was removed from rabbit radius(total = 9; 5 coated, 4 uncoated), and the segment was injected with 1 × 106 colony forming units(CFUs) of Staphylococcus aureus(UAMS-1 strain). Titanium wires were inserted throughthe intramedullary canal of the removed segment and into the proximal radial segment and the segment was placed back into the defect. After 7 d, limbs were removed, X-rayed, swabbed for tissue contamination. Wires were removed and processed to determine attached CFUs. Tissue was swabbed and streaked on agar plates to determine bacteriological score.RESULTS: Antibiotic-loaded coatings resulted in significantly reduced biofilm formation(4.7 fold reduction in CFUs; P < 0.001) on titanium wires and reduced bacteriological score in surrounding tissue(4.0 ± 0 for uncoated, 1.25 ± 0.5 for coated; P = 0.01). Swelling and pus formation was evident in uncoated controls at the 7 d time point both visually and radiographically, but not in antibiotic-loaded coatings.CONCLUSION: Active antibiotic was released from coated implants and significantly reduced signs of osteomyelitic symptoms. Implant coatings were well tolerated in bone. Further studies with additional control groups and longer time periods are warranted. Antibiotic-loaded phosphatidylcholine coatings applied at the point of care could prevent implant-associated infection in orthopaedic defects. | Jessica Amber Jennings Karen E Beenken Robert A Skinner Daniel G Meeker Mark S Smeltzer Warren O Haggard Karen S Troxel | 2016 | World Journal of Orthopedics2016，7，8： | 2 |
| 4 | Postpartum uterine flora following normal and abnormal puerperium in cows显示文摘 | Hussain A M Daniel R C W Oboyle O | 1990 | Theriogenology1990，34，： | 1 |
| 5 | Stroke-related seitures and the role of cortical and subcortical structures显示文摘 | Ferraro G Mattaliano A | 1996 | J Epilepsy1996，9，： | 1 |
| 6 | Endothelial signal integration in vascular assembly显示文摘 | DANIEL T O A BRAHAMSON D | 2000 | Annu Rev Physiol2000，62，： | 1 |
| 7 | Analysis of gene transcription in bovine nuclear transfer embryos reconstructed with granulose cell nuclei显示文摘 | DANIELS R HALL V TROUNSON A O | 2006 | Biol Reprod2006，3，4： | 1 |
| 8 | School-- related Social Support and Students'Perceived Life Satisfaction 显示文摘 | Daniel sen A D Samdal O Hetland J | 2009 | The Journal of Educational Research2009，，4： | 1 |
| 9 | Analysis of gene transcription in bovine nuclear transfer embryos reconstructed with granulosa cell nuclei显示文摘 | Daniels R Hall V Trounson A O | 2000 | Biol Reprod2000，63，： | 1 |
| 10 | Effect of starvation on biological factors related to immunological defense in the Sydney rock oyster (Saccostrea glomerata) 显示文摘 | Daniel Butt Saleem Aladaileh Wayne A O'Connor | 2007 | Aquaculture2007，264，： | 1 |
| 11 | Robust design simulation: a probabilistic approach to multidisciplinary design 显示文摘 | Mavris D N Bandte O Daniel A D | 1999 | Journal of Aircraft1999，36，1： | 1 |
| 12 | Optimizing the spinning reserve re- quirements using a cost/benefit analysis显示文摘 | Miguel A O Daniel S K | 2007 | IEEE Trans on Power Systems2007，22，1： | 1 |
| 13 | Miller Fisher Syndrome: 10 Years’ Experience in a Third-Level Center显示文摘 | San-juan O Daniel Martínez-herrera José Fabián Moreno García Jael Fernández Gonzalez-aragon Maricarmen Del Castillo-calcáneo Juan De Dios Pérez-neri Iván | 2009 | European Neurology2009，，3： | 1 |
| 14 | Prediction of outcome in head and-neck cancer patients using the standardized uptake value of 2- fluoro 2-deoxy-D-glucose显示文摘 | Abdelkarim S A Daniel O S Tayeb K | 2004 | Int J Radiat Oncol Biol Phys2004，59，5： | 1 |
| 15 | Hemispheric Cerebellar rTMS to Treat Drug-resistant Epilepsy:Case Reports显示文摘 | BRIGHINA F DANIELE O PIAZZA A | 2006 | Neurosci Lett(S0304-3940)2006，397，3： | 1 |
| 16 | The Planning Response to Urban Service Sector Growth : An International Comparison 显示文摘 | DANIELS P W K O'Connor T A HUTTON | 1991 | Growth and Change1991，326，： | 1 |
| 17 | Simultaneous monitoring of oil film thickness and temperature in fluid film bearings 显示文摘 | Sergei B Glavatskih a O sten Uusitalo a Daniel J Spohn b | 2001 | Tribology International2001，34，： | 1 |
| 18 | Reduced-energy cranberry juice increases folic acid and adiponectin and reduces homocysteine and oxidative stress in patients with the metabolic syndrome显示文摘 | Tathiana Name Colado Sim?o Marcell Alysson Batisti Lozovoy Andréa Name Colado Sim?o Sayonara Rangel Oliveira Danielle Venturini Helena Kaminami Morimoto Lúcia Helena Silva Miglioranza Isaias Dichi | 2013 | British Journal of Nutrition2013，，10： | 1 |
| 19 | Anti-inflammatory ,antinociceptive and cytotoxic effects of the methanolextract of Cecropia Pachystachya Trecul 显示文摘 | DANIELLE M O A 1SADEL V A L JOSIANE M S | 2013 | PhytotherapyResearch2013，27，6： | 1 |
| 20 | Fertilization of mouse oocytes using somatic cells as male germ cells显示文摘 | Lacham-Kaplan O Daniels R Trounson A | 2001 | Reprod Biomed Online2001，3，3： | 1 |
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