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| 1 | Operative complications and economic outcomes of cholecystectomy for acute cholecystitis显示文摘BACKGROUND Recent management of acute cholecystitis favors same admission(SA)or emergent cholecystectomy based on overall shorter hospital stay and therefore cost savings.We adopted the practice of SA cholecystectomy for the treatment of acute cholecystitis at our tertiary care center and wanted to evaluate the economic benefit of this practice.We hypothesized that the existence of complications,particularly among patients with a higher degree of disease severity,during SA cholecystectomy could negate the cost savings.AIM To compare complication rates and hospital costs between SA vs delayed cholecystectomy among patients admitted emergently for acute cholecystitis.METHODS Under an IRB-approved protocol,complications and charges for were obtained for SA,later after conservative management(Delayed),or elective cholecystectomies over an 8.5-year period.Patients were identified using the acute care surgery registry and billing database.Data was retrieved via EMR,operative logs,and Revenue Cycle Operations.The severity of acute cholecystitis was graded according to the Tokyo Guidelines.TG18 categorizes acute cholecystitis by Grades 1,2,and 3 representing mild,moderate,and severe,respectively.Comparisons were analyzed withχ2,Fisher’s exact test,ANOVA,ttests,and logistic regression;significance was set at P<0.05.RESULTS Four hundred eighty-six(87.7%)underwent a SA while 68 patients(12.3%)received Delayed cholecystectomy.Complication rates were increased after SA compared to Delayed cholecystectomy(18.5%vs 4.4%,P=0.004).The complication rates of patients undergoing delayed cholecystectomy was similar to the rate for elective cholecystectomy(7.4%,P=0.35).Mortality rates were 0.6%vs 0%for SA vs Delayed.Patients with moderate disease(Tokyo 2)suffered more complications among SA while none who were delayed experienced a complication(16.1%vs 0.0%,P<0.001).Total hospital charges for SA cholecystectomy were increased compared to a Delayed approach($44500±$59000 vs$35300±$16700,P=0.019).The relative risk of developing a complication was 4.2x[95%confidence interval(CI):1.4-12.9]in the SA vs Delayed groups.Among eight patients(95%CI:5.0-12.3)with acute cholecystitis undergoing SA cholecystectomy,one patient will suffer a complication.CONCLUSION Patients with Tokyo Grade 2 acute cholecystitis had more complications and increased hospital charges when undergoing SA cholecystectomy.This data supports a selective approach to SA cholecystectomy for acute cholecystitis. | Christopher P Rice Krishnamurthy B Vaishnavi Celia Chao Daniel Jupiter August B Schaeffer Whitney R Jenson Lance W Griffin William J Mileski | 2019 | World Journal of Gastroenterology2019，25，48： | 8 |
| 2 | Maintenance infliximab for Crohn’s disease: the ACCENT I randomised trial显示文摘 | Stephen B Hanauer Brian G Feagan Gary R Lichtenstein Lloyd F Mayer S Schreiber Jean Frederic Colombel Daniel Rachmilewitz Douglas C Wolf Allan Olson Weihang Bao Paul Rutgeerts | 2002 | The Lancet2002，，9317： | 6 |
| 3 | EGF promotes mammalian cell growth by suppressing cellular senescence显示文摘 | Peter B Alexander Lifeng Yuan Pengyuan Yang Tao Sun Rui Chen Handan Xiang Jiekai Chen Haoyu Wu Daniel R Radiloff Xiao-Fan Wang | 2015 | Cell Research2015，25，1： | 3 |
| 4 | 2009年南极冰穹A的双色天光背景统计和分析显示文摘天光背景是天文台址的一个重要指标。利用2009年位于南极冰穹A的CSTAR望远镜两个波段的观测数据,对南极冰穹A的天光背景进行了统计和分析。结果表明约74%的g波段天光背景的ADU值小于每像素100/s;90.5%的r波段的天光背景的ADU值小于每像素100/s。在不考虑大气消光的情况下,定标后的结果为2009年冰穹A的观测数据中天光背景亮度的中值:g波段为19.9 mag/arcsec2,r波段为20.1 mag/arcsec2。 | 宗伟凯 付建宁 牛家树 Ashley Michael C B 宫雪非 Lawrence J S 刘强 Luong-Van Daniel Pennypacker C R Storey John W V 王灵芝 王力帆 杨惠根 袁祥岩 York Donald G 朱镇熹 | 2014 | 天文研究与技术2014，11，1： | 2 |
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| 7 | Twenty years of inten- sive fertilization and competing vegetation suppression in loblolly pine plantations: Impacts on soil C,N, and microbial biomass显示文摘 | Sami W R Daniel M Bruce B | 2010 | Soil Biology & Biochemistry2010，42，5： | 1 |
| 8 | Measurement of combustionkinetics of a single char particle in an electrodynamicthermogravimetric analyzer 显示文摘 | Bar-Ziv E Daniel B J Rik S R | 1989 | Combustion andFlame1989，75，1： | 1 |
| 9 | Suppression of allergic immune responses to house dust mite (HDM) in rats exposed to 2,3,7,8-TCDD显示文摘 | Luebke R W Copeland C B Daniels M | 2001 | Toxicol Sci2001，62，1： | 1 |
| 10 | Fentanyl aug- ments the blockade of the sympathetic response to incision (MAC-BAR) produced by desflurane and isoflurane: Des- flurane and isoflurane MAC-BAR without and with fentanyl 显示文摘 | Daniel M Weiskopf R B Noorani M | 1998 | Anesthesiology1998，88，1： | 1 |
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| 12 | Crystallization of para-Xylene in Scraped-Surface Crystallizers显示文摘 | Daniel B P James B R Hazim A M | 2001 | AICh E J2001，47，11： | 1 |
| 13 | Therapeuticuse of citrulline in cardiovascular disease显示文摘 | MARITZA J R DANIEl H P RUTH B C | 2006 | Cardiovascul Drug Rev2006，24，34： | 1 |
| 14 | elegans developing embryos显示文摘 | Daniels B R Masi B C Wirtz D Probing single-cell micromechanics in vivo: the microrheology of C | 2006 | Biophys J2006，90，： | 1 |
| 15 | Fentanyl augments the blockade of the sympathetic response to incision (MAC BAR) produced by desfturane and isoflurane: desflurane and isoflurane MAC-BAR without and with fentanyl显示文摘 | Daniel M Weiskopf R B Noorani M | 1998 | Anesthesi- ology1998，88，1： | 1 |
| 16 | A 'Tric' to tighten cell-cell junctions in the cochlea for hearing显示文摘 | Higashi Tomohito Lenz Danielle R Furuse Mikio Avraham Karen B | 2013 | Journal of Clinical Investigation2013，，9： | 1 |
| 17 | Treatment of acute exacerbations of chronic bronchitis: comparison of trovafloxacin and amoxicillin in a multicentre,double- blind,double- dummy study显示文摘 | O'Doherty B Daniel R | 1998 | Eur J Clin Microbiol Infect Dis1998，17，6： | 1 |
| 18 | Isolation and iden tification of synthetic pyrethroid-degrading bacteria显示文摘 | GRANT R J DANIELL T J BETTS W B | 2002 | Journal of Applied Microbiology2002，92，3： | 1 |
| 19 | Copper electrodeposition on pyrolytic graphite electrodes:Effect of the copper salt on the electrodeposition process 显示文摘 | Ouassim G Lionel R Daniel B | 2007 | Electrochimica Acta2007，52，19： | 1 |
| 20 | Xenon purity analysis for exo-200 via mass spectrometry 显示文摘 | Dobi A Hall C Slutsky S Yen Y R Aharmin B Auger M Barbeau P S Benitez-Medina C Breidenbach M Cleveland B Conley R Cook J Cook S Counts I Craddock W Daniels T Davis C G Davis J Devoe R Dixit M Dolinski M J Donato K Fairbank Jr W Farine J Fierlinger P Franco D Giroux G Gornea R Graham K Gratta G Green C Hagemann C Hall K Hallman D Hargrove C Herrin S Hughes M Hodgson J Juget F Karelin A Kaufman L J Kuchenkov A Kumar K Leonard D S Lutter G Mackay D Maclellan R Marino M Mong B Montero Diez M Morgan P MUller A R Neilson R Odian A Oullivan K Piepke A Pocar A Prescott C Y Pushkin K Rivas A Rollin E Rowson P C Sabourov A Sinclair D Skarpaas K Stekhanov V Strickland V Swift M Twelker K Vuilleumier J L Vuilleumier J M Weber M Wichoski U Wodin J Wright J D Yang L | 2012 | Nuclear Instruments and Methods in Physics Research Section A: Accelerators Spectrometers Detectors and Associated Equipment2012，675，： | 1 |
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