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| 1 | Human albumin solution for patients with cirrhosis and acute on chronic liver failure: Beyond simple volume expansion显示文摘To provide an overview of the properties of human serum albumin(HSA), and to review the evidence for the use of human albumin solution(HAS) in critical illness, sepsis and cirrhosis. A MEDLINE search was performed using the terms 'human albumin', 'critical illness', 'sepsis' and 'cirrhosis'. The references of retrieved articles were reviewed manually. Studies published between 1980 and 2014 were selected based on quality criteria. Data extraction was performed by all authors. HSA is the main plasma protein contributing greatly to its oncotic pressure. HSA demonstrates important binding properties for endogenous and exogenous toxins, drugs and drug metabolites that account for its anti-oxidant and anti-inflammatory properties. In disease states, hypoalbuminaemia is secondary to decreased HSA production, increased loss or transcapillary leakage into the interstitial space. HSA function can be also altered in disease with reduced albumin binding capacity and increased production of modified isoforms. HAS has been used as volume expander in critical illness, but received criticism due to cost and concerns regarding safety. More recent studies confirmed the safety of HAS, but failed to show any survival benefit compared to the cheaper crystalloid fluids, therefore limiting its use. On the contrary, in cirrhosis there is robust data to support the efficacy of HAS for the prevention of circulatory dysfunction post-large volume paracentesis and in the context of spontaneous bacterial peritonitis, and for the treatment of hepato-renal syndrome and hypervolaemic hyponatraemia. It is likely that not only the oncotic properties of HAS are beneficial in cirrhosis, but also its functional properties, as HAS replaces the dysfunctional HSA. The role of HAS as the resuscitation fluid of choice in critically ill patients with cirrhosis, beyond the established indications for HAS use, should be addressed in future studies. | Christopher Valerio Eleni Theocharidou Andrew Davenport Banwari Agarwal | 2016 | World Journal of Hepatology2016，8，7： | 7 |
| 2 | Lipopolysaccharide inhibits or accelerates biomedical titanium corrosion depending on environmental acidity显示文摘Titanium and its alloys are routinely used as biomedical implants and are usually considered to be corrosion resistant under physiological conditions. However, during inflammation, chemical modifications of the peri-implant environment including acidification occur. In addition certain biomolecules including lipopolysaccharide(LPS), a component of Gram-negative bacterial cell walls and driver of inflammation have been shown to interact strongly with Ti and modify its corrosion resistance. Gram-negative microbes are abundant in biofilms which form on dental implants. The objective was to investigate the influence of LPS on the corrosion properties of relevant biomedical Ti substrates as a function of environmental acidity. Inductively coupled plasma mass spectrometry was used to quantify Ti dissolution following immersion testing in physiological saline for three common biomedical grades of Ti(ASTM Grade 2, Grade 4 and Grade 5). Complementary electrochemical tests including anodic and cathodic polarisation experiments and potentiostatic measurements were also conducted. All three Ti alloys were observed to behave similarly and ion release was sensitive to p H of the immersion solution. However, LPS significantly inhibited Ti release under the most acidic conditions(p H 2), which may develop in localized corrosion sites, but promoted dissolution at p H 4–7, which would be more commonly encountered physiologically.The observed pattern of sensitivity to environmental acidity of the effect of LPS on Ti corrosion has not previously been reported. LPS is found extensively on the surfaces of skin and mucosal penetrating Ti implants and the findings are therefore relevant when considering the chemical stability of Ti implant surfaces in vivo. | Fei Yu Owen Addison Stephen J Baker Alison J Davenport | 2015 | International Journal of Oral Science2015，7，3： | 5 |
| 3 | 摩擦搅拌焊接技术已在欧洲推广应用显示文摘日本已有许多台没有熔接缝的铝合金车辆 ,欧洲的铁道车辆生产厂家正在设法利用 1 | John Davenport 苑春艳 | 2002 | 国外机车车辆工艺2002，，4： | 4 |
| 4 | Difficulties in diagnosing acute kidney injury post liver transplantation using serum creatinine based diagnostic criteria显示文摘Renal function in patients with advanced cirrhosis is an important prognostic factor for survival both prior to and following liver transplantation. The importance of renal function is reflected by the introduction of the model for end stage liver disease(MELD) score, which includes serum creatinine. The MELD score has been shown to predict the short term risk of death for transplant wait listed patients and is currently used by many countries to allocate liver transplants on the basis of severity of underlying illness. Changes in serum creatinine are also used to stage acute kidney injury. However prior to liver transplantation the serum creatinine typically over estimates underlying renal function, particularly when a colorimetric Jaffe based assay is used, and paradoxically then under estimates renal function post liver transplantation, particularly when immunophyllins are started early as part of transplant immunosuppression. As acute kidney injury is defined by changes in serum creatinine, this potentially leads to over estimation of the incidence and severity of acute kidney injury in the immediate post-operative period. | Banwari Agarwal Andrew Davenport | 2014 | World Journal of Hepatology2014，6，10： | 4 |
| 5 | Can non-invasive measurements aid clinical assessment of volume in patients with cirrhosis?显示文摘AIM:To evaluate the non-invasive assessments of volume status in patients with cirrhosis.METHODS:Echocardiography and multifrequency bioimpedance analysis measurements and short synacthen tests were made in 20 stable and 25 acutely decompensated patients with cirrhosis.RESULTS:Both groups had similar clinical assessments,cortisol response and total body water(TBW),however the ratio of extracellular water(ECW)/TBW was significantly greater in the trunk(0.420±0.004 vs0.404±0.005),and limbs(R leg 0.41±0.003 vs 0.398±0.003,P<0.05,and L leg 0.412±0.003 vs 0.399±0.003)with decompensated cirrhosis compared to stable cirrhotics,P<0.05).Echocardiogram derived right atrial and ventricular filling and end diastolic pressures and presence of increased left ventricular end diastolic volume and diastolic dysfunction were similar in both groups.The decompensated group had lower systemic blood pressure,mean systolic 101.8±4.3 vs122.4±5.3 and diastolic 58.4±4.1 mmHg vs 68.8±3.1 mmHg respectively,P<0.01,and serum albumin30(27-33)vs 32(31-40.5)g/L,P<0.01.CONCLUSION:Decompensated cirrhotics had greater leg and truncal ECW expansion with lower serum albumin levels consistent with intravascular volume depletion and increased vascular permeability. | Andrew Davenport Banwari Argawal Gavin Wright Konstantinos Mantzoukis Rumyana Dimitrova Joseph Davar Panayota Vasianopoulou Andrew K Burroughs | 2013 | World Journal of Hepatology2013，5，8： | 3 |
| 6 | Gastric endoscopic submucosal dissection as a treatment for early neoplasia and for accurate staging of early cancers in a United Kingdom Caucasian population显示文摘AIM To investigate the efficacy of endoscopic submucosal dissection(ESD) at diagnosing and treating superficial neoplastic lesions of the stomach in a United Kingdom Caucasian population.METHODS Data of patients treated with or considered for ESD at a tertiary referral center in the United Kingdom were retrieved for a period of 2 years(May 2015 to June 2017) from the electronic patient records of the hospital. Only Caucasian patients were included. Primary outcomes were curative resection(CR) and were defined as ESD resections with clear horizontal and vertical margin and an absence of lympho-vascular invasion, poor differentiation and submucosal involvement on histological evaluation of the resected specimen. Secondary end-points were reversal of dysplasia at 12 mo endoscopic follow-up and/or at the latest follow up. Change in histological diagnosis pre and post ESD was also analysed.RESULTS Twenty-four patients were initially identified with intention to treat. 19 patients were eligible after mapping gastroscopy and ESD was attempted on a total of 25 ESD lesions, 4 of which failed and had to be aborted mid-procedure. Out of 21 ESD performed, en-bloc resection was achieved in 71.4% of cases. Resection was considered complete on endoscopy in 90.5% of cases compared to only 38.1% on histology. A total of 6 resections were considered curative(28%), 5 noncurative(24%) and 10 indefinite for CR or non-CR(24%). ESD changed the histological diagnosis in 66.6% of cases post ESD. Endoscopic follow-up in the 'indefinite' group and CR group showed that 50% and 80% of patients were clear of dysplasia at the latest follow-up respectively; 2 cases of recurrence were observed in the 'indefinite'group. Survival rate for the entire cohort was 91.7%.CONCLUSION This study provides early evidence for the efficacy of ESD as a therapeutic and diagnostic intervention in Caucasian populations and supports its application in the United Kingdom. | Aisha Sooltangos Matthew Davenport Stephen McGrath Jonathan Vickers Siba Senapati Kurshid Akhtar Regi George Yeng Ang | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，12： | 3 |
| 7 | A Simple Proof of the Restricted Isometry Property for Random Matrices显示文摘 | Richard Baraniuk Mark Davenport Ronald DeVore Michael Wakin | 2008 | Constructive Approximation2008，，3： | 3 |
| 8 | A Simple Proof of the Restricted Isometry Property for Random Matrices显示文摘 | Richard Baraniuk Mark Davenport Ronald DeVore Michael Wakin | 2008 | Constructive Approximation2008，，3： | 3 |
| 9 | Biliary atresia显示文摘 | Jane L Hartley Mark Davenport Deirdre A Kelly | 2009 | The Lancet . 2009 (9702)2009，，： | 2 |
| 10 | Extraction and characterisation of lipids from Antarctic krill ( Euphausia superba )显示文摘 | Joseph C. Gigliotti Matthew P. Davenport Sarah K. Beamer Janet C. Tou J. Jaczynski | 2010 | Food Chemistry2010，，3： | 2 |
| 11 | Biliary atresia显示文摘 | Jane L Hartley Mark Davenport Deirdre A Kelly | 2009 | 2009 (9702)2009，，9702： | 2 |
| 12 | Relational dual of the c-means algorithms 显示文摘 | Hathaway R J Davenport J W Bezdek J C | 1989 | Pattern Recognition1989，22，2： | 2 |
| 13 | Development of necrotizing enterocolitis after blood transfusion in very premature neonates显示文摘Background Prior studies report conflicting evidence on the association between packed red blood cell(PRBC)transfu-sions and necrotizing enterocolitis(NEC),especially in early weeks of life where transfusions are frequent and spontaneous intestinal perforation can mimic NEC.The primary objective of this study was to evaluate the association between PRBC transfusions and NEC after day of life(DOL)14 in very premature neonates.Methods A retrospective cohort analysis of very premature neonates was conducted to investigate association between PRBC transfusions and NEC after DOL 14.Primary endpoints were PRBC transfusions after DOL 14 until the date of NEC diagnosis,discharge,or death.Wilcoxon ranked-sum and Fisher's exact tests,Cox proportional hazards regression,and Kaplan-Meier curves were used to analyze data.Results Of 549 premature neonates,186(34%)received transfusions after DOL 14 and nine(2%)developed NEC(median DOL=38;interquartile range=32-46).Of the nine with NEC after DOL 14,all were previously transfused(P<0.001);therefore,hazard of NEC could not be estimated.Post hoc analysis of patients from DOL 10 onward included five additional patients who developed NEC between DOL 10 and DOL 14,and the hazard of NEC increased by a factor of nearly six after PRBC transfusion(hazard ratio=5.76,95%confidence interval=1.02-32.7;P=0.048).Conclusions Transfusions were strongly associated with NEC after DOL 14.Prospective studies are needed to determine if restrictive transfusion practices can decrease incidence of NEC after DOL 14. | Travis L.Odom Jessica Eubanks Nusiebeh Redpath Erica Davenport Dmitry Tumin Uduak S.Akpan | 2023 | World Journal of Pediatrics2023，19，1： | 2 |
| 14 | Successful knowledge management projects显示文摘 | Davenport T T De Long D W Beers M C | 1998 | Sloan Management Review1998，，11： | 2 |
| 15 | Spontaneous intracranial hypotension from a CSF leak in a patient with Maffan's syndrome显示文摘 | Davenport RJ Chataway SJ Warlow CP | 1995 | J Neurol Neurosurg Psychiatry1995，59，5： | 2 |
| 16 | Single-pixel imaging via compressive sampling 显示文摘 | DUARTE M F DAVENPORT M A TAKHAR D | 2008 | IEEE Signal Processing Magazine2008，25，2： | 1 |
| 17 | Reduced serum concentrations of insulin-like growth factor- I (IGF- I ) in protein-restricted growing rats are accompanied by reduced IGF- I mRNA levels in liver and skeletal muscle显示文摘 | Vandehaar M J IVloats-Staats B M Davenport M L | 1991 | Journal of Endocrinology1991，130，： | 1 |
| 18 | Single-pixel imaging via compressive sampling显示文摘 | Marco Duarte Mark Davenport Dharmpal Takhar | 2008 | IEEE Signal Processing Magazine2008，25，2： | 1 |
| 19 | Modulation of cytochrome P450 enzymes by organosulfur compounds from garlic显示文摘 | Davenport DM Wargovich MJ | 2005 | Food Chem Toxicol2005，43，： | 1 |
| 20 | The New Industrial Engineering:Information Technology and Business Process Redesign显示文摘 | DAVENPORT T H SHORT J | 1990 | Sloan Management Review1990，31，4： | 1 |
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