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| 1 | High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes显示文摘Screening gene function in vivo is a powerful approach to discover novel drug targets. We present high-throughput screening(HTS) data for 3 762 distinct global gene knockout(KO) mouse lines with viable adult homozygous mice generated using either gene-trap or homologous recombination technologies. Bone mass was determined from DEXA scans of male and female mice at 14 weeks of age and by microCT analyses of bones from male mice at 16 weeks of age. Wild-type(WT) cagemates/littermates were examined for each gene KO. Lethality was observed in an additional 850 KO lines. Since primary HTS are susceptible to false positive findings, additional cohorts of mice from KO lines with intriguing HTS bone data were examined. Aging,ovariectomy, histomorphometry and bone strength studies were performed and possible non-skeletal phenotypes were explored. Together, these screens identified multiple genes affecting bone mass: 23 previously reported genes(Calcr, Cebpb, Crtap, Dcstamp, Dkk1, Duoxa2, Enpp1, Fgf23, Kiss1/Kiss1 r, Kl(Klotho),Lrp5, Mstn, Neo1, Npr2, Ostm1, Postn, Sfrp4, Slc30a5, Slc39a13, Sost, Sumf1, Src, Wnt10b), five novel genes extensively characterized(Cldn18, Fam20 c, Lrrk1, Sgpl1, Wnt16), five novel genes with preliminary characterization(Agpat2, Rassf5, Slc10a7, Slc26a7, Slc30a10) and three novel undisclosed genes coding for potential osteoporosis drug targets. | Robert Brommage Jeff Liu Gwenn M Hansen Laura L Kirkpatrick David G Potter Arthur T Ss Brian Zambrowicz David R Powell Peter Vogel | 2014 | Bone Research2014，2，3： | 7 |
| 2 | The MRE11 GAR motif regulates DNA double-strand break processing and ATR activation显示文摘MRE11/RAD50/NBS1 建筑群是很快招募到 DNA 双海滨裂缝(DSB ) 的主要传感器。MRE11 被知道是由在它的 glycine-arginine-rich (长嘴硬鳞鱼) 以内的 PRMT1 的精氨酸 methylated 主题。在这研究,我们报导在 GAR 主题与离氨酸代替精氨酸并且产生 MRE11 缺乏 methylated 精氨酸的 RK 蛋白质。Mre11 RK/RK 老鼠对 γ 过分敏感;照耀(红外) 和从这些老鼠的房间显示了房间周期检查点缺点和染色体不稳定性。而且, Mre11 RK/RK MEF 展出了在 RPA 和 RAD51 的招募表明缺点和缺陷到损坏地点的 ATR/CHK1。M RK 形成的 RN 建筑群并且对 DNA 损坏并且通常的地点局部性响应红外激活 ATM 小径。M RK RN 建筑群在为响应红外在 vivo 观察的损害 DNA 结束切除术和 ATR 激活负责的 vitro 展出了 exonuclease 和 DNA 有约束力的缺点。我们的调查结果在 DSB 修理为 MRE11 长嘴硬鳞鱼主题的关键角色提供基因证据,并且在 MRE11 长嘴硬鳞鱼表明在 translational 以后修正之间的一个机械学的连接主题并且 DSB 处理,以及发信号的 ATR/CHK1 检查点。 | Zhenbao Yu Gillian Vogel Yan Coulombe Danielle Dubeau Elizabeth Spehalski Josee Hebert David O Ferguson Jean Yves Masson Stephane Richard | 2012 | Cell Research2012，22，2： | 5 |
| 3 | Multilocus Phylogeny of Lycodon and the Taxonomic Revision of Oligodon multizonatum显示文摘Classification of the Asian snake genera Lycodon and Oligodon has proven challenging. We conducted a molecular phylogenetic analysis to estimate the phylogenetic relationships in the genus of Lycodon and clarify the taxonomic status of Oligodon multizonatum using mitochondrial(cyt b, ND4) and nuclear(c-mos) genes. Phylogenetic trees estimated using Maximum Likelihood and Bayesian Inference indicated that O. multizonatum is actually a species of Lycodon. Comparing morphological data from O. multizonatum and its closest relatives also supported this conclusion. Our results imply that a thorough review of the evolutionary relationships in the genus of Lycodon is strong suggested. | Juan LEI Xiaoyu SUN Ke JIANG Gernot VOGEL David T.BOOTH Li DING | 2014 | Asian Herpetological Research2014，5，1： | 3 |
| 4 | Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery显示文摘 | Mary C Corretti Todd J Anderson Emelia J Benjamin David Celermajer Francois Charbonneau Mark A Creager John Deanfield Helmut Drexler Marie Gerhard-Herman David Herrington Patrick Vallance Joseph Vita Robert Vogel | 2002 | Journal of the American College of Cardiology2002，，： | 2 |
| 5 | Sex differences in the use of demand and withdraw behavior in marriage: Examining the social structure hypothesis 显示文摘 | David L Vogel Megan J Murphy Ronald J Wemer-Wilson | 2007 | Journal of Counseling Psychology2007，54，2： | 1 |
| 6 | Agrobacterium -mediated transformation and inbred line development in the model grass Brachypodium distachyon显示文摘 | John P. Vogel David F. Garvin Oymon M. Leong Daniel M. Hayden | 2006 | Plant Cell Tissue and Organ Culture2006，，2： | 1 |
| 7 | A revision of Lycodon ruhstrati(Fischer,1886) auctorum (Squamata:Colubridae),with the description of a new species from Thailand and a new subspecies from the Asian mainland显示文摘 | Vogel G David P Pauwels O S G | 2009 | Tropical Zoology2009，22，： | 1 |
| 8 | Experimental in vivo and in vitro models of multiple sclerosis: EAE and beyond显示文摘 | Markus Kipp Baukje van der Star Daphne Y.S. Vogel Fabìola Puentes Paul van der Valk David Baker Sandra Amor | 2012 | Multiple Sclerosis and Related Disorders2012，，1： | 1 |
| 9 | Trading up and governing across :transnational aovemance and environmental protection 显示文摘 | Vogel David | 1997 | Journal of European Public Poli- cy1997，56，4： | 1 |
| 10 | Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery显示文摘 | Mary C Corretti Todd J Anderson Emelia J Benjamin David Celermajer Francois Charbonneau Mark A Creager John Deanfield Helmut Drexler Marie Gerhard-Herman David Herrington Patrick Vallance Joseph Vita Robert Vogel | 2002 | Journal of the American College of Cardiology2002，，2： | 1 |
| 11 | Trading Up: Consumer and Environ- mental Regulation In a Global Economy 显示文摘 | Vogel David | 1995 | Southern Eco- nomic Association1995，63，： | 1 |
| 12 | When Consumers Oppose Consumer Protection: The Politics of Regulatory Backlash 显示文摘 | Vogel David | 1990 | Journal of Public Policy1990，10，4： | 1 |
| 13 | Description of a new species of the genus Trimeresurus from Thailand, related to Trimeresurus stejnegeri Schmidt, 1925 (Serpentes, Crotalidae) 显示文摘 | David P G Vogel O S G Pauwels and N Vidal | 2002 | Natural History Journal of Chulalongkorn University2002，2，： | 1 |
| 14 | Towards a structure - function analysis of bovine lactoferricin and related tryptophan- and arginine-containing peptides Biochem 显示文摘 | HANS J VOGEL DAVID J SCHIBLI WEIGUO JING | 2002 | Cell Biol2002，80，： | 1 |
| 15 | The structureof the antimicrobial active center of lactoferricin B bound tosodium dodecyl sulfate micelles 显示文摘 | David J Schibli Peter M Hwang Hans J Vogel | 1999 | FEBS Letters1999，446，： | 1 |
| 16 | Tryptophan- and arginine-rich antimicrobial peptides: Structures and mechanisms of action显示文摘 | David I. Chan Elmar J. Prenner Hans J. Vogel | 2006 | BBA - Biomembranes2006，，： | 1 |
| 17 | Adult Attachment,Affect Regulation,Negative Mood,and Interpersonal Problems:The Mediating Roles of Emotional Reactivity and Emotional Cutoff显示文摘 | Meifen Wei David L Vogel | 2005 | Journal of Counseling Psychology2005，52，1： | 1 |
| 18 | Structural insights into the mechanical regulation of molecular recognition sites显示文摘 | Viola Vogel Wendy E Thomas David W Craig André Krammer Gretchen Baneyx | 2001 | Trends in Biotechnology2001，，10： | 1 |
| 19 | The Mammalian Fatty Acid-binding Protein Multigene Family: Molecular and Genetic Insights into Function显示文摘 | Ann Vogel Hertzel David A Bernlohr | 2000 | Trends in Endocrinology & Metabolism2000，，5： | 1 |
| 20 | Towards a structure-function analysis of bovine lacto ferricin and related tryptophan and arginine contai- ning peptides显示文摘 | Vogel Hans J Schibli David J Jing Weiguo | 2002 | Biochemistry and Cell Biology2002，80，1： | 1 |
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