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| 1 | Fondaparinux预防老年急性内科患者发生静脉血栓形成的效果与安全性:随机安慰剂对照研究显示文摘目的:观察 Fondaparinux 对具有中高度静脉血栓发生危险的老年急性内科住院患者的抗凝效果与安全性。设计:双盲随机安慰剂对照研究。背景:8个国家的35个中心。参与者:849例≥60岁内科患者,住院原因分别为充血性心力衰竭、慢性肺病合并急性呼吸系统疾患、急性炎症性或感染性疾病,预期至少住院4天以上。干预:2.5 mg Fondaparinux 或安慰剂,每天1次皮下注射,持续6~14天。观察指标:主要指标为静脉血栓形成(治疗后15天内采用双侧静脉造影检查)及有症状的静脉血栓;次要指标为死亡与出血。患者随访时间为1个月。结果:Fondaparinux 治疗组425例患者和安慰剂组414例患者接受了安全性分析(10例未治疗)。644例患者(75.9%)可接受主要指标分析。静脉血栓检出率在 Fondaparinux 治疗组为5.6%(18/321),安慰剂组为10.5%(34/323),相对危险减少46.7%(95% CI 7.7%~69.3%)。安慰剂组5例患者发生有症状的静脉血栓,Fondaparinux治疗组无患者发生有症状的静脉血栓(P=0.029)。两组均有1例(0.2%)患者发生严重出血。随访结束时,安慰剂组、Fondaparinux 治疗组分别死亡25(6.0%)、14(3.3%)例患者。结论:Fondaparinux 可有效预防急性内科老年患者无症状性及有症状的静脉血栓。严重出血几率两组相似。 | Alexander T Cohen Bruce L Davidson Alexander S Gallus Michael R Lassen Martin H Prins Witold Tomkowski Alexander G G Turpie Jan F M Egberts Anthonie W A Lensing 石汉平(译) 王深明(校) | 2006 | 英国医学杂志中文版2006，9，5： | 3 |
| 2 | Protection of the liver by ischemic preconditioning: a review of mechanisms and clinical applications显示文摘 | Koti R S Seifalian A M Davidson B R | 2003 | Dig Surg2003，20，5： | 2 |
| 3 | Severe Hand, Foot, and Mouth Disease Associated with Coxsackievirus A6 - Alabama, Connecticut, California, and Nevada, November 201 1 - February 2012显示文摘 | McIntyre Mary G Stevens Kelly M Davidson Sherri Pippin Tina Magill Dagny Kulhanjian Julie A Kelly Daniel Greenhow Tara L Salas Maria L Yagi Shigeo Padilla Tasha Berumen Ricardo Glaser Carol Landry Marie Louise Lott Jason Chen Lei Paulson | 2012 | EN2012，，12： | 2 |
| 4 | Comparison of the efficacy and safety of rosuvastatin versus atorvastatin , simvastatin , and pravastatin across doses (STELLAR * * STELLAR = Statin Therapies for Elevated Lipid Levels compared Across doses to Rosuvastatin. Trial)显示文摘 | Peter H Jones Michael H Davidson Evan A Stein Harold E Bays James M McKenney Elinor Miller Valerie A Cain James W Blasetto | 2003 | The American Journal of Cardiology2003，，2： | 2 |
| 5 | Postprandial hyperglycaemia and cardiovascular complications of diabetes:an update显示文摘 | Davidson J Hanefeld M | 2006 | Nutr Metab Cardiovasc Dis2006，16，： | 1 |
| 6 | Periodic Solution of a Lotka Voherra Predator-prey Model with Dispersion and Time Delays 显示文摘 | R Xu M A J Chaplain F A Davidson | 2004 | Applied Mathematics and Computation2004，148，： | 1 |
| 7 | Interleukin - 2 sig -naling via STAT5 constrains T helper 17 cell generation显示文摘 | Laurence A Tato C M Davidson T S | 2007 | Im- munity2007，26，3： | 1 |
| 8 | Postprandial hypergly- caemia and cardiovascular complications of diabetes: an update 显示文摘 | Ceriello A Davidson J Hanefeld M | 2006 | Nutr Metab Cardiovasc Dis2006，16，7： | 1 |
| 9 | Persistence and stability for a two-species ratio-dependent predator-prey system with distributed time delay 显示文摘 | Xu R Davidson F A Chaplain M A J | 2002 | Journal of Mathematical Analysis and Applications2002，269，： | 1 |
| 10 | Existence of a microporous corona around the me_sopore of silica- based SBA- 15 materials tem01ated by triblock copolymers显示文摘 | Imperor C M Davidson P Davidson A | 2000 | J am chem soc2000，122，11： | 1 |
| 11 | Effect of sample preparation on the operational speciation of cadmium and lead in a freshwater sediment 显示文摘 | Davidson C M Wilson L E Ure A M | 1999 | Fresenius'' Journal of Analytical Chemistry1999，363，： | 1 |
| 12 | Dexmedetomidine infusion for analgesia and prevention Of emergence agitation in children with obstructive sleep apnea syndrome undergoing tonsillectomy and adenoidectomy显示文摘 | Patel A Davidson M Tran MC | 2010 | Anesth Analg2010，111，4： | 1 |
| 13 | Comparison of the efficacy and safety of rosuvastatin versus atorvastatin, simvasta- tin, and pravastatin across doses (STELLAR Trial ) 显示文摘 | JONES P H DAVIDSON M H STEIN E A | 2003 | Am J Cardiol2003，92，2： | 1 |
| 14 | Improved cardiovascular stability during continuous of renal replacement therapy in critically ill patients with acute hepatic and renal failure 显示文摘 | Davenport A Will E J Davidson A M | 1993 | Crit Care Med1993，21，： | 1 |
| 15 | Mutagenesis of the dengue virus type 2 NS3 protein within and outside helicase motifs:effects on enzyme activity and virus replication显示文摘 | Matusan A E Pryor M J Davidson A D | 2001 | J Virol2001，75，： | 1 |
| 16 | Chemoendocrine therapy for premenopausal women with axillary lymph node-positive,steroid hormone receptor-positive breast cancer:results from INT 0101 (E5188)显示文摘 | Davidson N E O'Neill A M Vukov A M | 2005 | J Clin Oncol2005，23，25： | 1 |
| 17 | Pseudotetrahedral O3/2V=O centers immobilized on the walls of a mesoporous cubic MCM-48 support: preparation, characterization, and reactivity toward water as investigated by 51 V NMR and UV-V is spectroscopies显示文摘 | Morey M Davidson A Eckert H | 1996 | Chem Mater1996，8，2： | 1 |
| 18 | Periodic Solutions for a Delayed Predator-prey Model of Prey Dispersal in Twopatch Environments 显示文摘 | XU Rtti CHAPLAIN M A J DAVIDSON F A | 2004 | Nonlinear Analysis2004，，5： | 1 |
| 19 | A phylogenyof the tropical genus Piper using ITS and the chloroplastintron psbi-petA显示文摘 | Jaramillo M A Calleijas R Davidson C | 2008 | Systematic Botany2008，33，4： | 1 |
| 20 | NADPH Oxidase and Nrf2 Regulate Gastric Aspiration-in- duced Inflammation and Acute Lung Injury显示文摘 | Davidson B A Vethanayagam R R Grimm M J | 2013 | J Immunol2013，190，4： | 1 |
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