|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Thiopurine-methyltransferase variants in inflammatory bowel disease:Prevalence and toxicity in Brazilian patients显示文摘AIM:To analyze the prevalence of thiopurine-methyltransferase(TPMT)genotypes and their associationwith drug toxicity in inflammatory bowel disease(IBD)patients from southeastern Brazil.METHODS:A total of 219 consecutive patients with IBD,of which 146 had Crohn’s disease and 73 had ulcerative colitis,regularly seen at the outpatient unit of the Division of Gastroenterology at the University Hospital Pedro Ernesto of the State University of Rio de Janeiro,a tertiary referral center,were enrolled in this study from February 2009 to January 2011.We analyzed the presence of major TPMT genetic variants(TPMT*2,*3A,*3C)in IBD patients by means of a specific allele and RFLP-PCR.Genomic DNA was isolated from peripheral blood leukocytes by proteinase-K/Sodium Dodecyl Sulfate digestion and phenol-chloroform extraction.TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes were detected by real-time polymerase chain reaction followed by direct sequencing with specific primers.Clinical data were systematically recorded,and correlated with the genotype results.RESULTS:The distribution of the selected TPMT gene polymorphism TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes was 3.6%,5.4%,and 7.7%of the patients,respectively.Among the side effects recorded from patients taking azathioprine,14 patients presented with pancreatitis and/or an elevation of pancreatic enzymes,while 6 patients had liver toxicity,and 2 patients exhibited myelosuppression/neutropenia.TPMT polymorphisms were detected in 37/219 patients(8 heterozygous for*2,11 heterozygous for*3A,and 18 heterozygous for*3C).No homozygotic polymorphisms were found.Despite the prevalence of the TPMT*3C genotype,no differences among the genotype frequencies were significant.Although no association was detected regarding myelotoxicity or hepatotoxicity,a trend towards the elevation of pancreatic enzymes was observed for TPMT*2 and TPMT*3C genotypes.CONCLUSION:The prevalence of TPMT genotypes was high among Brazilian patients.Variants genes*2and*3C may be associated with azathioprine pancreatic toxicity in a IBD southeastern Brazilian population. | Ana Teresa P Carvalho Barbara C Esberard Renata S B Fróes Davy C M Rapozo Ana B Grinman Tatiana A Simo Juliana C V C Santos Antonio José V Carneiro Luis Felipe Ribeiro-Pinto Heitor S P de Souza | 2014 | World Journal of Gastroenterology2014，20，12： | 3 |
| 2 | Impact dynamics in milling of thin-walled structures 显示文摘 | Davies M A Balachandran B | 2000 | Nonlinear Dynamic2000，22，4： | 1 |
| 3 | Bioretention column studies of phosphorus removal from urban storm water runoff显示文摘 | Hsieh C H Davis A P Needleman B A | 2007 | Water Environ Res2007，79，2： | 1 |
| 4 | The purification and characterization of extremely thermostable α-amylase from the hyperthmophilic archaebacterium Pyrococcus furiosus显示文摘 | Laderman K A Davis B R Krutzsch H C | 1993 | The Journal of Biological Chemistry1993，268，24： | 1 |
| 5 | 5-epi-deoxyrhamnojirimycin is a potent inhibitor of an α-L-rhamnosidase:5-epi-deoxymannojirimycin is not a potent inhibitor of an α-D-mannosidase显示文摘 | Davis B G Hull A Smith C | 1998 | Tetrahedron:Asymmetry1998，9，： | 1 |
| 6 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
| 7 | Three-dimensionalseismic imaging of dikefed submarine volcanoes显示文摘 | Davies R Bell B Cartwright J A | 2002 | Geology2002，30，： | 1 |
| 8 | Calcium anidotrihydroborate:a hydrogen storage material显示文摘 | Diyabalanage H V K Shrestha R P Semelsberger TA Scott B L Bowden M E Davis B L Burrell A K | | 0，，47： | 1 |
| 9 | Fischer-Tropsch reactors显示文摘 | Steynberg A Dry M Davis B | 2004 | Studies in Surface Science and Catalysis2004，152，： | 1 |
| 10 | The expression of calbindin in chicks that are divergently selected for low or high incidence of tibial dyschondroplasia显示文摘 | SHIRLEY R B DAVIS A J COMPTON M M | 2003 | Poultry Science2003，82，12： | 1 |
| 11 | Pneumocystis colonisation is common among hospitalised HIV infected patients with nonpneumocystis pneumonia显示文摘 | Davis J L Welsh D A Beard C B | 2008 | Thorax2008，63，4： | 1 |
| 12 | The temperature of Europe during the Holoeene reconstructed from pollen data显示文摘 | Davis B A S Brewer S Stevenson A C | 2003 | Quaternary Science Reviews2003，22，1517： | 1 |
| 13 | Laparoscopic dismembered pyeloplasty-the method of choice in the presence of an enlarged renal pelvis and crossing vessels显示文摘 | Turk I A Davis J W Winkelmann B | 2002 | Eur Urol2002，42，： | 1 |
| 14 | The Stability of Low Radial Immersion Milling 显示文摘 | DAVIES M A DUTTERER B PRATT J R | 2000 | Annals of the CIRP2000，49，1： | 1 |
| 15 | Activities and postantibiotic effects of gemifloxacin compared to those of 11 other agents against Haemophilus influenzae and Moraxella catarrhalis显示文摘 | Davies T A Kelly L M Hoellman D B | 2000 | Antimicrob Agents Chemother2000，44，3： | 1 |
| 16 | Abdominal aortic aneurysms are associated with altered matrix proteins of the nonaneurysmal aortic segments显示文摘 | BAXTER B T DAVIS V A Minion D J | 1994 | J Vasc Surg1994，19，： | 1 |
| 17 | Overexpres sion of brain-derived neurotrophic factor enhances sensory in nervation and selectively increases neuron number显示文摘 | LeMaster A M Krimm R F Davis B M | 1999 | J Neu rosci1999，19，14： | 1 |
| 18 | Cathelicidins: Microbicidal activity, mechanisms of action, and roles in in- nate immunity显示文摘 | Ramanathan B Davis E G Ross C R et a l | 2002 | Microb Infect2002，4，： | 1 |
| 19 | Trust, Expertise and Ecommerce Intermediary Adoption 显示文摘 | Chircu A M Davis G B Kauffman R J | 2000 | In Proceedings of the Sixth Americas Conference on Information System2000，，8： | 1 |
| 20 | The role of seed banks in the vegetation dynamics of prairie glacial marshes显示文摘 | VANDER V A G DAVIS C B | 1978 | Ecology1978，59，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员