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| 1 | Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation显示文摘 | D.L Lacey E Timms H.-L Tan M.J Kelley C.R Dunstan T Burgess R Elliott A Colombero G Elliott S Scully H Hsu J Sullivan N Hawkins E Davy C Capparelli A Eli Y.-X Qian S Kaufman I Sarosi V Shalhoub G Senaldi J Guo J Delaney W.J Boyle | 1998 | Cell1998，，2： | 4 |
| 2 | Thiopurine-methyltransferase variants in inflammatory bowel disease:Prevalence and toxicity in Brazilian patients显示文摘AIM:To analyze the prevalence of thiopurine-methyltransferase(TPMT)genotypes and their associationwith drug toxicity in inflammatory bowel disease(IBD)patients from southeastern Brazil.METHODS:A total of 219 consecutive patients with IBD,of which 146 had Crohn’s disease and 73 had ulcerative colitis,regularly seen at the outpatient unit of the Division of Gastroenterology at the University Hospital Pedro Ernesto of the State University of Rio de Janeiro,a tertiary referral center,were enrolled in this study from February 2009 to January 2011.We analyzed the presence of major TPMT genetic variants(TPMT*2,*3A,*3C)in IBD patients by means of a specific allele and RFLP-PCR.Genomic DNA was isolated from peripheral blood leukocytes by proteinase-K/Sodium Dodecyl Sulfate digestion and phenol-chloroform extraction.TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes were detected by real-time polymerase chain reaction followed by direct sequencing with specific primers.Clinical data were systematically recorded,and correlated with the genotype results.RESULTS:The distribution of the selected TPMT gene polymorphism TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes was 3.6%,5.4%,and 7.7%of the patients,respectively.Among the side effects recorded from patients taking azathioprine,14 patients presented with pancreatitis and/or an elevation of pancreatic enzymes,while 6 patients had liver toxicity,and 2 patients exhibited myelosuppression/neutropenia.TPMT polymorphisms were detected in 37/219 patients(8 heterozygous for*2,11 heterozygous for*3A,and 18 heterozygous for*3C).No homozygotic polymorphisms were found.Despite the prevalence of the TPMT*3C genotype,no differences among the genotype frequencies were significant.Although no association was detected regarding myelotoxicity or hepatotoxicity,a trend towards the elevation of pancreatic enzymes was observed for TPMT*2 and TPMT*3C genotypes.CONCLUSION:The prevalence of TPMT genotypes was high among Brazilian patients.Variants genes*2and*3C may be associated with azathioprine pancreatic toxicity in a IBD southeastern Brazilian population. | Ana Teresa P Carvalho Barbara C Esberard Renata S B Fróes Davy C M Rapozo Ana B Grinman Tatiana A Simo Juliana C V C Santos Antonio José V Carneiro Luis Felipe Ribeiro-Pinto Heitor S P de Souza | 2014 | World Journal of Gastroenterology2014，20，12： | 3 |
| 3 | Sofosbuvir with pegylated interferon alfa-2a and ribavirin for treatment-naive patients with hepatitis C genotype-1 infection (ATOMIC): an open-label, randomised, multicentre phase 2 trial显示文摘 | Kris V Kowdley Eric Lawitz Israel Crespo Tarek Hassanein Mitchell N Davis Michael DeMicco David E Bernstein Nezam Afdhal John M Vierling Stuart C Gordon Jane K Anderson Robert H Hyland Hadas Dvory-Sobol Di An Robert G Hindes Efsevia Albanis William T Symo | 2013 | The Lancet2013，，9883： | 3 |
| 4 | Mathematical modeling of the extrusion of 6061/A12O3/20p composite 显示文摘 | CHEN W C DAVIES C H J SAMARASEKERA I V | 1996 | Matallurgical and Materials Transactions1996，，27： | 2 |
| 5 | A new and highly efficient grubbs initiator for ring-opening metathesis polymerization显示文摘 | Robson D A Gibson V C Davies R G | 1999 | Macromolecules1999，32，19： | 1 |
| 6 | Commutation failures in HVDC transmission systems显示文摘 | Thio C V Davies J B Kent K L | 1996 | IEEE Trans on Power Delivery1996，11，2： | 1 |
| 7 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
| 8 | Commutation Failures in HVDC Transmission Systems显示文摘 | THIO C V DAVIES J B KENT K L | | 0，，02： | 1 |
| 9 | Evidence on the political economy of the urbanization process 显示文摘 | Davis J C Henderson J V | 2003 | Journal of Urban Economics2003，53，1： | 1 |
| 10 | A computer simulation of multi-ship encounters显示文摘 | DAVIS P V DOVE M J STOCKEL C T | 1982 | Journal of Navigation1982，35，： | 1 |
| 11 | Modulation of sodium transport in fetal alveolar epithelial cells by oxygen and eorticosterone显示文摘 | Thome U H Davis I C Nguyen S V | 2003 | Am J Physiol Lung Cell Mol Physiol2003，284，2： | 1 |
| 12 | High-accuracy Analog Measurements Via Interpolated FFT显示文摘 | Jane V K Collins W L Jr Davis D C | 1979 | IEEE Trans-M1979，28，2： | 1 |
| 13 | Commutation failures in HVDC transmission systems显示文摘 | Thio C V Davies J B Kent K L | 1996 | IEEE Trans on Power Delivery1996，11，2： | 1 |
| 14 | Effect of dietary man-nan oligosaccharides and(or)pharmacological additions of cop-per sulfate on growth performance and immunocompetence ofweanling and growing/finishing pigs显示文摘 | Davis M E Maxwell C V Brown D C | 2002 | J Anim Sci2002，80，11： | 1 |
| 15 | High-accuracy analog measurement via interpolated FFT 显示文摘 | Jain V K Collins W L Davis D C | 1979 | IEEE Trans IM1979，28，2： | 1 |
| 16 | Transverse response of underground cavities and pipes to incident SV waves显示文摘 | Davis C A Lee V W Bardet J P | 2001 | Earthquake Engineering and Structural Dynamics2001，30，： | 1 |
| 17 | The role of seed banks in the vegetation dynamics of prairie glacial marshes显示文摘 | VANDER V A G DAVIS C B | 1978 | Ecology1978，59，： | 1 |
| 18 | A computer simulation of marine traffic using domains and arenas显示文摘 | DAVIS P V DOVE M J STOCKEL C T | 1980 | Journal of Navigation1980，33，2： | 1 |
| 19 | Empirical atomic sensitivity factors for quantitative analysis by electron spectroscopy for chemical analysis显示文摘 | Wagner C D Davis L E Zeller M V | 1981 | Surf Int Anal1981，3，5： | 1 |
| 20 | Normal human CD4^+ memory T cells display broad heterogeneity in their activation threshold for cytokine synthesis 显示文摘 | Waldrop S L Davis K A Maino V C | 1998 | J Immunol1998，161，10： | 1 |
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