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| 1 | Diet and microbiota in inflammatory bowel disease: The gut in disharmony显示文摘Bacterial colonization of the gut shapes both the local and the systemic immune response and is implicated in the modulation of immunity in both healthy and disease states. Recently, quantitative and qualitative changes in the composition of the gut microbiota have been detected in Crohn's disease and ulcerative colitis, reinforcing the hypothesis of dysbiosis as a relevant mechanism underlying inflammatory bowel disease(IBD) pathogenesis. Humans and microbes have coexisted and co-evolved for a long time in a mutually beneficial symbiotic association essential for maintaining homeostasis. However, the microbiome is dynamic, changing with age and in response to environmental modifications. Among such environmental factors, food and alimentary habits, progressively altered in modern societies, appear to be critical modulators of the microbiota, contributing to or co-participating in dysbiosis. In addition, food constituents such as micronutrients are important regulators of mucosal immunity, with direct or indirect effects on the gut microbiota. Moreover, food constituents have recently been shown to modulate epigenetic mechanisms, which can result in increased risk for the development and progression of IBD. Therefore, it is likely that a better understanding of the role of different food components in intestinal homeostasis and the resident microbiota will be essential for unravelling the complex molecular basis of the epigenetic, genetic and environment interactions underlying IBD pathogenesis as well as for offering dietary interventions with minimal side effects. | Davy CM Rapozo Claudio Bernardazzi Heitor Siffert Pereira de Souza | 2017 | World Journal of Gastroenterology2017，23，12： | 24 |
| 2 | Thiopurine-methyltransferase variants in inflammatory bowel disease:Prevalence and toxicity in Brazilian patients显示文摘AIM:To analyze the prevalence of thiopurine-methyltransferase(TPMT)genotypes and their associationwith drug toxicity in inflammatory bowel disease(IBD)patients from southeastern Brazil.METHODS:A total of 219 consecutive patients with IBD,of which 146 had Crohn’s disease and 73 had ulcerative colitis,regularly seen at the outpatient unit of the Division of Gastroenterology at the University Hospital Pedro Ernesto of the State University of Rio de Janeiro,a tertiary referral center,were enrolled in this study from February 2009 to January 2011.We analyzed the presence of major TPMT genetic variants(TPMT*2,*3A,*3C)in IBD patients by means of a specific allele and RFLP-PCR.Genomic DNA was isolated from peripheral blood leukocytes by proteinase-K/Sodium Dodecyl Sulfate digestion and phenol-chloroform extraction.TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes were detected by real-time polymerase chain reaction followed by direct sequencing with specific primers.Clinical data were systematically recorded,and correlated with the genotype results.RESULTS:The distribution of the selected TPMT gene polymorphism TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes was 3.6%,5.4%,and 7.7%of the patients,respectively.Among the side effects recorded from patients taking azathioprine,14 patients presented with pancreatitis and/or an elevation of pancreatic enzymes,while 6 patients had liver toxicity,and 2 patients exhibited myelosuppression/neutropenia.TPMT polymorphisms were detected in 37/219 patients(8 heterozygous for*2,11 heterozygous for*3A,and 18 heterozygous for*3C).No homozygotic polymorphisms were found.Despite the prevalence of the TPMT*3C genotype,no differences among the genotype frequencies were significant.Although no association was detected regarding myelotoxicity or hepatotoxicity,a trend towards the elevation of pancreatic enzymes was observed for TPMT*2 and TPMT*3C genotypes.CONCLUSION:The prevalence of TPMT genotypes was high among Brazilian patients.Variants genes*2and*3C may be associated with azathioprine pancreatic toxicity in a IBD southeastern Brazilian population. | Ana Teresa P Carvalho Barbara C Esberard Renata S B Fróes Davy C M Rapozo Ana B Grinman Tatiana A Simo Juliana C V C Santos Antonio José V Carneiro Luis Felipe Ribeiro-Pinto Heitor S P de Souza | 2014 | World Journal of Gastroenterology2014，20，12： | 3 |
| 3 | Pro-lactin levels and adverse events in patients treated with risperidone显示文摘 | Kleinberg DL Davis JM de Coster R | 1999 | Clin Psychopharmaco11999，19，1： | 1 |
| 4 | Characterization of the behavior of rubber for engineering design purpose显示文摘 | De K D Thomas A G | 1994 | Rubber Chem Tech1994，67，4： | 1 |
| 5 | Prolactin levels and adverse events in patients treated with risperidone显示文摘 | Kleinberg CL Davis JM de Coster R | 1999 | J Clin Psychopharmacol1999，19，： | 1 |
| 6 | Pneumomediastinum after dental surgery显示文摘 | Davies DE | 2001 | Anaesth Intensive Care2001，29，6： | 1 |
| 7 | Economic Geography and Regional Production Structure:An Empirical Investigation显示文摘 | Davies DR Weinstein DE | | 0，，02： | 1 |
| 8 | The bronchial epithelium: translating gene and environment interactions in asthma 显示文摘 | Davies DE | 2001 | Curr Opin Allergy Clin lmmunol2001，1，： | 1 |
| 9 | Airway remodel- ing in asthma: new insights 显示文摘 | Davies DE Wicks J Powell RM | 2003 | J Allergy Clin Immunol2003，111，25： | 1 |
| 10 | ADAM 33 and its association with airway remodeling and hyperresponsiveness in asthma显示文摘 | Holqate ST Davies DE Rorke S | 2004 | Clin Rev Allergy Immunol2004，27，1： | 1 |
| 11 | Foot strike patterns and collision forces in habitually barefoot versus shod runners显示文摘 | Lieberman DE Venkadesan M Werbel WA Daoud AI D'Aeandrea S Davis IS | | 0，，： | 1 |
| 12 | A study on the modification of mesoporous mixed oxides supports for dry reforming of methane by Pt or Ru 显示文摘 | Davi C Carvalho Helvio Silvester A de Souza Josu M Filho | 2014 | Applied Catalysis A : General2014，47，： | 1 |
| 13 | Efficiency of the laser texturing on the adhesion of the coated twist drills 显示文摘 | Davi Neves Anselmo Eduardo Diniz Milton Sergio Fernandes de Lima | 2006 | Journal of Materials Processing Technology2006，179，： | 1 |
| 14 | The comparative developmental neurotoxicity of lead in humans and animals 显示文摘 | Davis JM Otto DA Weil DE | 1990 | Neurotoxicol Teratol1990，12，： | 1 |
| 15 | Market Access,Economic Geography and Comparative Advantage:An Empirical Test显示文摘 | Davies DR Weinstein DE | | 0，，01： | 1 |
| 16 | AT4 receptor activation increases intracellular calciuminflux and induces a non-N-methyl-D-aspartate dependent form of long-term potentiation 显示文摘 | Davis CJ Kramar EA De A | 2006 | Neuroscience2006，137，4： | 1 |
| 17 | Celebrating group and place identity: a case study of a new regional festival显示文摘 | De Bres Karen and Davis James | 2001 | Tourism Geographies2001，3，3： | 1 |
| 18 | Disparate effects of angiontensin Ⅱantagonists and calcium channel blockers on albuminuria in experimental diabetes and hypertension:potential role of nephrin显示文摘 | Cao Z de Gasparo M | 2003 | J Hypertens2003，21，1： | 1 |
| 19 | Numerical and Experimental Characterization ~f a Natural Gas Engine with Partially Stratified Charge Spark Igni- tion显示文摘 | Chan E C Davy M H de Simone G | 2011 | Journal of Engineering for Gas Turbines and Power2011，133，： | 1 |
| 20 | 2,4-Dialkyl-8,9,10,11-tetrahydrobenzo[ g ]pyrimido[4,5- c ]isoquinoline-1,3,7,12(2 H ,4 H )-tetraones as new leads against Mycobacterium tuberculosis显示文摘 | Pieter Claes Davie Cappoen Cynthia Uythethofken Jan Jacobs Birgit Mertens Vanessa Mathys Luc Verschaeve Kris Huygen Norbert De Kimpe | 2014 | European Journal of Medicinal Chemistry2014，，： | 1 |
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