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| 1 | Management and outcome of hepatocellular adenoma with massive bleeding at presentation显示文摘AIM To evaluate outcome of acute management and risk of rebleeding in patients with massive hemorrhage due to hepatocellular adenoma(HCA). METHODS This retrospective cohort study included all consecutive patients who presented to our hospital with massive hemorrhage(grade Ⅱ or Ⅲ) due to ruptured HCA and were admitted for observation and/or intervention between 1999-2016. The diagnosis of HCA was based on radiological findings from contrastenhanced magnetic resonance imaging(MRI) or pathological findings from biopsy or resection of the HCA. Hemorrhage was diagnosed based on findings from computed tomography or MRI. Medical records were reviewed for demographic features, clinical presentation, tumor features, initial and subsequent management, short-and long-term complications and patient and lesion follow-up. RESULTS All patients were female(n = 23). Treatment in the acute phase consisted of embolization(n = 9, 39.1%), conservative therapy(n = 13, 56.5%), andother intervention(n = 1, 4.3%). Median hemoglobin level decreased significantly more on days 0-3 in the intervention group than in the patients initially treated conservatively(0.9 mmol/L vs 2.4 mmol/L respectively, P = 0.006). In total, 4 patients suffered severe shortterm complications, which included hypovolemic shock, acute liver failure and abscess formation. After a median follow-up of 36 mo, tumor regression in nonsurgically treated patients occurred with a median reduction of 76 mm down to 25 mm. Four patients underwent secondary(elective) treatment(i.e., tumor resection) to address HCA size of > 5 cm and/or desire for future pregnancy. One case of rebleeding was documented(4.3%). None of the patients experienced long-term complication(mean follow-up time: 36 mo). CONCLUSION With a 4.3% risk of rebleeding, secondary(elective) treatment of HCA after massive hemorrhage may only be considered in patients with persistent HCA > 5 cm. | Anne J Klompenhouwer Robert A de Man Maarten GJ Thomeer Jan NM Ijzermans | 2017 | World Journal of Gastroenterology2017，23，25： | 5 |
| 2 | 阿尔茨海默病患者脑血流的动态调节显示文摘脑自动调节和压力反射敏感性是维持脑血流量的关键机制。该研究评估了这些调控机制在阿尔茨海默病导致的痴呆和轻度认知障碍患者中是否受到影响,因为这会增加降压治疗的风险。 | 刘青 叶鹏 de Heus RAA de Jong DLK Sanders ML van Spijker GJ Oudegeest-Sander MH Hopman MT Lawlor BA Olde Rikkert MGM Claassen JAHR | 2018 | 中华高血压杂志2018，26，8： | 4 |
| 3 | Evaluation, prevention and management of radiotherapy- induced xerostomia in head and neck cancer patients显示文摘 | de Castro GJ Federico MH | 2006 | Curr Opin Oncol2006，18，3： | 1 |
| 4 | Intrapatient comparion of restenosis between carotid artery angioplasty with stenting and carotid endarterectomy显示文摘 | De Borst GJ Hellings WE Ackerstaff RG | 2006 | J Cardiovasc Surg2006，47，1： | 1 |
| 5 | Electrocardiographic abnormalities and serum magnesium in patients with sunarachnoid hemorrhage显示文摘 | Van de WA Algra A Rinkel GJ | 2004 | Stroke2004，35，： | 1 |
| 6 | Continuous subcutaneous insulin infusion (CSII) versus conventional injection therapy in newly diagnosed diabetic children : Two - year follow - up of a randomized, prospective trial显示文摘 | De Beaufort CE Houtzagers CM Bruining GJ | 1989 | Diabet Med1989，6，9： | 1 |
| 7 | Telomerase in (pre) neoplastic cervical disease 显示文摘 | Wisman GB De Jong S Meersma GJ | 2000 | Hun Pathol2000，31，10： | 1 |
| 8 | Is sleeve gas- trectomy as effective as gastric bypass for remission of type 2 diabetes in morbidly obese patients? 显示文摘 | de Gordejuela AG Pujol GJ Garcia NV | 2011 | Surg Obes Relat Dis2011，7，4： | 1 |
| 9 | The cytochrome c maturation operon is involved in manganese oxidation in Pseudomonas putida GB-I 显示文摘 | de Vrind JPM Brouwers GJ Corstjens PLAM den Dulk J de Vrind?de Jong EW | 1998 | Appl Environ Microbiol1998，64，10： | 1 |
| 10 | Symptomatic internal carotid artery occlusion; a long-term follow-up study显示文摘 | Persoon S Luitse MJ de Borst GJ etal | 2011 | J Neurol Neurosurg Psychiatry2011，82，5： | 1 |
| 11 | Assertive community treatment of severe mental illness: a Canadian experience 显示文摘 | Lafave HG de Souza HR Gerber GJ | 1996 | Psyehiatr Serv1996，47，7： | 1 |
| 12 | Duplex scan in patients with clinical suspicion of deep venous thrombosis显示文摘 | de Oliveira A Franca GJ Vidal Ea | 2008 | Cardiovasc Ultrasound2008，206，： | 1 |
| 13 | Fat-cell changes as a mechanism of avascular necrosis of the femoral head in cortisone-treated rabbits显示文摘 | Wang GJ Sweet DE Reger SI | 1977 | J BoneJoint Surg Am1977，59，6： | 1 |
| 14 | Selection criteria for the clinical use of the newer antiepileptic drugs显示文摘 | Deckers CI Knoester PD de Haan GJ el al | 2003 | CNS Drugs2003，17，6： | 1 |
| 15 | Applied information retrieval and multidisciplinary research: new mechanistic hypotheses in Complex Regional Pain Syndrome显示文摘 | Kristina M Hettne Marissa de Mos Anke GJ de Bruijn | 2007 | Journal of Biomedical Discovery and Collaboration2007，2，2： | 1 |
| 16 | Cytomegalovir- us urinary excretion and long term outcome in children with con- genital cytomegalovirus infection 显示文摘 | Noyola DE Demmler GJ Williamson WD | 2000 | Pediatr Infect Dis2000，19，6： | 1 |
| 17 | Body composition in adult growth hormone-deficient men, assessed by anthropometry and bioimpedance analysis显示文摘 | De BH Blok GJ Voerman HJ | 1992 | J Clin Endocrinol Metab1992，75，3： | 1 |
| 18 | The role of[18F]-2-fluoro-2-deoxy-d-glucose-positron emission tomography in thyroid nodules with indeterminate fine-needle aspiration biopsy:systematic review and meta-analysis of the literature显示文摘 | Vriens D de Wilt JH van der Wilt GJ | | 0，，20： | 1 |
| 19 | Direct stimulation of ghrelin secretion by sympathetic nerves显示文摘 | Mundinger TO Cummings DE Taborsky GJ Jr | 2006 | Endocrinology2006，147，6： | 1 |
| 20 | Delayed cerebral ische- mia after subarachnoid hemorrhage a systematic review of clinical, laboratory and radiological predictors 显示文摘 | De Rooij NK Rinkel GJ Dankbaar JW | 2013 | Stroke2013，44，： | 1 |
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