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| 1 | Effects of selenomethionine on acute toxicities from concurrent chemoradiation for inoperable stage Ⅲ nonsmall cell lung cancer显示文摘AIM: To prospectively determine the safety and tolerability of oral L-selenomethionine(SLM) with concurrent chemoradiation(CCRT) for Stage Ⅲ non-small cell lung cancer(NSCLC) and estimate if the incidence and/or severity of adverse events could be reduced by its use.METHODS: Sixteen patients with stage Ⅲ NSCLC were accrued to this single arm, phase Ⅱ study. CCRT consisted of radiation given at 2 Gy per fraction for 30-33 fractions, 5 d per week with concurrent weekly Ⅳ paclitaxel 50 mg/m2 followed by carboplatin dosed at an area under the time-concentration curve of 2. SLM was dosed in a loading phase at 4800 μg twice daily for one week prior to CCRT followed by once daily dosing during treatment. RESULTS: No selenium-related toxicity was observed. Analysis revealed grade 3 or higher esophagitis in 3 of 16 patients(19%), pneumonitis in 0, leukopenia in 2(12.5%), and anemia in 1(6%); the latter two were significantly reduced when compared to the protocolstated expected rate of 35%(P = 0.045 for leukopenia, and P < 0.01 for anemia). Median overall survival was 14.9 mo and median failure-free survival was 9 mo(95%CI: 3.3-21.5).CONCLUSION: There may be some protective benefit of selenium in the setting of CCRT for inoperable NSCLC. The data suggests decreased rates of myelosuppression when compared to similarly-treated historical and contemporary controls. Further evaluation of selenium in this setting may be warranted. | Michael Mix Nithya Ramnath Jorge Gomez Charles de Groot Saju Rajan Shiva Dibaj Wei Tan Youcef Rustum Michael B Jameson Anurag K Singh | 2015 | World Journal of Clinical Oncology2015，6，5： | 4 |
| 2 | Magnetic and crystallographic properties of several C1b type Heusler compounds 显示文摘 | Helmholdt R B de Groot R A Mueller F M | 1984 | J Magn Magn Mater1984，43，： | 2 |
| 3 | B-type natriuretic peptide and peak exercise oxygen consumption provide independent information for risk stratification in patients with stable congestive heart failure 显示文摘 | de Groote P Dagorn J Soudan B | 2004 | J Am Coll Cardiol2004，43，9： | 1 |
| 4 | The effect of estrogen receptor genotype on litter size and placental traits at term in F2 crossbred gilts 显示文摘 | Van Rens B T de Groot P N Van Der L T | 2002 | Theriogenology2002，57，6： | 1 |
| 5 | Seismic inversion successfully predicts reservoir, porosity, and gas content in Ibhubesi Field, Orange Basin, South Africa 显示文摘 | Berge T B Fred Aminzadeh Paul de Groot | 2002 | The Leading Edge2002，21，4： | 1 |
| 6 | Structure and function of water channels显示文摘 | Fujiyoshi Y Mitsuoka K de Groot B L | 2002 | Curr Opin Struct Biol2002，12，4： | 1 |
| 7 | Water permeation across biological membranes: mechanism and dynamics of aqua- porirrl and GlpF显示文摘 | de Groot B L Grubmtiller H | 2001 | Science2001，294，： | 1 |
| 8 | Autoantibodies directed against domain Iof beta2-glycoprotein I 显示文摘 | de Laat B de Groot PG | 2011 | Curr Rheumatol Rep2011，13，1： | 1 |
| 9 | The consistency of large concerted motions in proteins in molecular dynamics simulations显示文摘 | de Groot B L van Aalten D M Amadei A | 1996 | Biophys J1996，71，4： | 1 |
| 10 | A quantum chemical explanation of the antioxidant activity of flavonoids显示文摘 | SASKIA A B E VAN ACKER MARCEL J DE GROOT el al | 1996 | Chem Res Toxicol1996，9，： | 1 |
| 11 | Non-islet cell tumor-induced hypoglycemia: a review of the literature including two new cases显示文摘 | de GROOT JWB RIKHOF B van DOORN J | 2007 | Ehdocr Relat Cancer2007，14，4： | 1 |
| 12 | Identifying fault and gas chimneys using multi-attributes and neural networks 显示文摘 | Meldahl P R Heggland B Bril and P de Groot | 2001 | The Leading Edge2001，20，5： | 1 |
| 13 | The Value of the World's Ecosystem Services and Natural Capital显示文摘 | Costanza R d'Arge R de Groot R Farberk S Grasso M Hannon B Limburg K Naeem S O'Neill R V Paruelo J Raskin R G Suttonkk P van den Belt M | | 0，，6630： | 1 |
| 14 | The association between sports participation, alcohol use and aggression violence: A systematic review显示文摘 | Snderlund A O' Brien K Kremer P Rowland B De Groot F Stalger P Zinkiewicz L Miller P | 2014 | Journal of Science & Medicine in Sport2014，17，1： | 1 |
| 15 | Lupus anticoagu-lants and the risk of a first episode of deep venous thrombosis 显示文摘 | DE GROOT PG LUTTERS B DERKSEN RH | 2005 | JThromb Haemost2005，3，： | 1 |
| 16 | The role of Cu on the reduction behavior and surface properties of Fe-based Fischer-Tropsch catalysts显示文摘 | De SMIT E De GROOT F M F BLUME R HAVECKER M KNOP-GERICKE A WECKHUYSEN B M | 2010 | Phys Chem Chem Phys2010，12，3： | 1 |
| 17 | Z pinches-a historical view显示文摘 | Spielman R B De Groot J S | 2001 | Laser and Particle Beams2001，19，： | 1 |
| 18 | Re-lationships with activation markers of T cells,Bcells,and monocytes显示文摘 | Descamps-Latscha B Herbelin A Nguyen AT Roux-Lombard P Zingraff J Moynot A Verger C DahmaneD De Groote D Jungers P:Balance between IL-1 be-ta TNF-alpha and their specific inhibitors inchronic renal failure and maintenance dialysis | 1995 | J Immunol1995，，： | 1 |
| 19 | Developing an epitope-driven tuberculosis (TB) vaccine 显示文摘 | de GROOT A S MCMURRY J MARCON b | 2005 | Vaccine2005，23，2： | 1 |
| 20 | COMMD1 promotes pVHL and O2-independent proteolysis of HIF- 1 alpha via HSP90/70显示文摘 | van de Sluis B Groot AJ Vermeulen J | 2009 | PLoS One2009，4，10： | 1 |
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