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| 1 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 2 | Squamous cell carcino- ma antigen isoforms in serum from cervical cancer patients显示文摘 | Roijer E de Bruijn HW Dahlen U | 2006 | Tumour Biol2006，27，3： | 1 |
| 3 | The influence of self-absorption on PET and PET/ CT shielding rectuirements显示文摘 | Elschot M de Wit TC de Jong HW | 2010 | Med Phys2010，37，6： | 1 |
| 4 | The ileal neo- bladder:complications and functional results in 363 patients af- ter 11 years of followup显示文摘 | Hautmann RE de Petriconi R Gottfried HW | 1999 | J Urol1999，161，2： | 1 |
| 5 | The transforming growth factor - beta/Smad signaling pathway is present and functional in human glomerular mesangial cells显示文摘 | Poncelet AC DE Caestecker MP Schnaper HW | 1999 | Kidney Int1999，56，4： | 1 |
| 6 | Building alliance capability: management techniques for superior alliance performance显示文摘 | Draulans J De Man A-P Volberda HW | 2002 | Long Range Planning2002，36，2： | 1 |
| 7 | Pre-treatment serum squamous cell carcinoma antigen: a newly identified prognostic factor in early-stage cervical carcinoma 显示文摘 | Duk JM Groeneier KH de Bruijn HW | 1996 | J Clin Oncol1996，14，1： | 1 |
| 8 | Building alliance capability:management techniques for superior allianceperformance显示文摘 | Draulans J De Man A-P Volberda HW | 2002 | Long Range Planning2002，36，2： | 1 |
| 9 | Imaging of various gastric lesions with 2D MPR and CT gastrography performed with multidetector CT显示文摘 | Kim JH Eun HW Goo DE | | 0，，： | 1 |
| 10 | Which factors determine the sexual function 1 year aRer childbirth? 显示文摘 | van Brummen HJ Bruinse HW van de Pol G | 2006 | B JOG2006，113，8： | 1 |
| 11 | Plasminogen activators and tumor development in the human colon:activity levels in normal mucosa,adenomatous polyps, and adenocarcinomas显示文摘 | de Bruin PA Griffioen G Verspaget HW | 1987 | Cancer Res1987，47，17： | 1 |
| 12 | Infertility in men: recent advances and continuing controversies 显示文摘 | De Kretser DM Baker HW | 1999 | J Clin Endocrinol Metab1999，84，10： | 1 |
| 13 | Exhaled nitric oxide (NO) is reduced shortly after bronchoconstriction to direct and indirect stimuli in asthma显示文摘 | de Gouw HW Hendriks J Woltman AM | 1998 | Am J Respir Crit Care Med1998，158，1： | 1 |
| 14 | DPP-4 inhibitors and combined treatment in type 2 diabetes:re-evaluation of clinical success and safe- ty显示文摘 | de Valk HW | 2007 | Rev Diabet Stud2007，4，3： | 1 |
| 15 | Tri-substitued trizoles as potent non-nucleoside inhibitors of the HIV-1 reverse transcriptase显示文摘 | DE LA ROSA M KIM HW GUNIC E | 2006 | Bioorg Med Chem Lett2006，16，17： | 1 |
| 16 | Do HbAlc levels and the self- monitoring of blood glucose levels adequately reflect glycaemic con- trol during pregnancy in women with type 1 diabetes mellitus? 显示文摘 | Kerssen A de Valk HW Visser GH | 2006 | Diabetologia2006，49，1： | 1 |
| 17 | Age-specific differences in treatment and survival of patients with cervical cancer in the southeast of the Netherlands,1986-t996显示文摘 | de Rijke JM van der Putten HW Lutgens LC | 2002 | Eur J Cancer2002，38，15： | 1 |
| 18 | Human leukocyte antigen-B27-associated uveitis:long-term follow-up and gender di?ferences显示文摘 | Braakenburg AM de Valk HW de Boer J | 2008 | American journal of ophthalmology2008，145，47： | 1 |
| 19 | High preva-lence of microalbuminuria in chronic heart failure patients 显示文摘 | van de Wal RM Asselbergs FWtPlokker HW | 2005 | JCard Fail2005，11，8： | 1 |
| 20 | Interactions between thioesterase su perfamily member 2 (THEM2)and phosphatidylcholine transfer protein(PC-TP)]imit hepatic triglyceride secretion显示文摘 | KANG HW COHEN DE | 2010 | Hepatology2010，52，1： | 1 |
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