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| 1 | Improving the outcomes in gastric cancer surgery显示文摘Gastric cancer remains a significant health problem worldwide and surgery is currently the only potentially curative treatment option. Gastric cancer surgery is generally considered to be high risk surgery and fiveyear survival rates are poor,therefore a continuous strive to improve outcomes for these patients is warranted. Fortunately,in the last decades several potential advances have been introduced that intervene at various stages of the treatment process. This review provides an overview of methods implemented in pre-,intra- and postoperative stage of gastric cancer surgery to improve outcome. Better preoperative risk assessment using comorbidity index(e.g.,Charlson comorbidity index),assessment of nutritional status(e.g.,short nutritional assessment questionnaire,nutritional risk screening- 2002) and frailty assessment(Groningen frailty indicator,Edmonton frail scale,Hopkins frailty) was introduced. Also preoperative optimization of patients using prehabilitation has future potential.Implementation of fast-track or enhanced recovery after surgery programs is showing promising results,although future studies have to determine what the exact optimal strategy is.Introduction of laparoscopic surgery has shown improvement of results as well as optimization of lymph node dissection.Hyperthermic intraperitoneal chemotherapy has not shown to be beneficial in peritoneal metastatic disease thus far.Advances in postoperative care include optimal timing of oral diet,which has been shown to reduce hospital stay.In general,hospital volume,i.e.,centralization,and clinical audits might further improve the outcome in gastric cancer surgery.In conclusion,progress has been made in improving the surgical treatment of gastric cancer.However,gastric cancer treatment is high risk surgery and many areas for future research remain. | Juul JW Tegels Michiel FG De Maat Karel WE Hulsewé Anton GM Hoofwijk Jan HMB Stoot | 2014 | World Journal of Gastroenterology2014，20，38： | 16 |
| 2 | 经冠状动脉造影证实的初次冠状动脉支架内血栓形成长期临床预后:431例临床分析显示文摘本研究(Dutch Stent Thrombosis Registry)为一项多中心研究,纳入了2004年1月至2007年2月期间经造影确认的ST病例。本研究ST的定义根据ARC分类为明确的血栓形成。根据事件发生的时间分为急性(24h之内)、亚急性(24h~30d)、晚期(30d~1年)和极晚期(1年以后)血栓形成。 | van Werkum JW Heestermans AA de Korte FI 张闻多 | 2009 | 中国心血管杂志2009，14，4： | 15 |
| 3 | m TOR signaling in liver regeneration: Rapamycin combined with growth factor treatment显示文摘AIM: To investigate the effects of mammalian target of rapamycin(mT OR) inhibition on liver regeneration and autophagy in a surgical resection model.METHODS: C57BL/6 mice were subjected to a 70% partial hepatectomy(PH) and treated intraperitoneally every 24 h with a combination of the m TOR inhibitor rapamycin(2.5 mg/kg per day) and the steroid dexamethasone(2.0 mg/kg per day) in phosphate bufferedsaline(PBS) or with PBS alone as vehicle control. In the immunosuppressant group, part of the group was treated subcutaneously 4 h prior to and 24 h after PH with a combination of human recombinant interleukin 6(IL-6; 500 μg/kg per day) and hepatocyte growth factor(HGF; 100 μg/kg per day) in PBS. Animals were sacrificed 2, 3 or 5 d after PH and liver tissue and blood were collected for further analysis. Immunohistochemical staining for 5-Bromo-2'-deoxyuridine(Brd U) was used to quantify hepatocyte proliferation. Western blotting was used to detect hepatic microtubule-associated protein 1 light chain 3(LC3)-Ⅱ protein expression as a marker for autophagy. Hepatic gene expression levels of proliferation-, inflammation- and angiogenesisrelated genes were examined by real-time reverse transcription-polymerase chain reaction and serum bilirubin and transaminase levels were analyzed at the clinical chemical core facility of the Erasmus MC-University Medical Center.RESULTS: m TOR inhibition significantly suppressed regeneration, shown by decreased hepatocyte proliferation(2% vs 12% Brd U positive hepatocyte nuclei at day 2, P < 0.01; 0.8% vs 1.4% at day 5, P = 0.02) and liver weight reconstitution(63% vs 76% of initial total liver weight at day 3, P = 0.04), and furthermore increased serum transaminase levels(aspartate aminotransferase 641 U/L vs 185 U/L at day 2, P = 0.02). Expression of the autophagy marker LC3-Ⅱ, which was reduced during normal liver regeneration, increased after mT OR inhibition(46% increase at day 2, P = 0.04). Hepatic gene expression showed an increased inflammation-related response [tumor necrosis factor(TNF)-α 3.2-fold upregulation at day 2, P = 0.03; IL-1Ra 6.0-fold upregulation at day 2 and 42.3-fold upregulation at day 5, P < 0.01] and a reduced expression of cell cycle progression and angiogenesis-related factors(HGF 40% reduction at day 2; vascular endothelial growth factor receptor 2 50% reduction at days 2 and 5; angiopoietin 1 60% reduction at day 2, all P ≤ 0.01). Treatmentwith the regeneration stimulating cytokine IL-6 and growth factor HGF could overcome the inhibitory effect on liver weight(75% of initial total liver weight at day 3, P = 0.02 vs immunosuppression alone and P = 0.90 vs controls) and partially reversed gene expression changes caused by rapamycin(TNF-α and IL-1Ra levels at day 2 were restored to control levels). However, no significant changes in hepatocyte proliferation, serum injury markers or autophagy were found.CONCLUSION: mT OR inhibition severely impairs liver regeneration and increases autophagy after PH. These effects are partly reversed by stimulation of the IL-6 and HGF pathways. | Suomi MG Fouraschen Petra E de Ruiter Jaap Kwekkeboom Ron WF de Bruin Geert Kazemier Herold J Metselaar Hugo W Tilanus Luc JW van der Laan Jeroen de Jonge | 2013 | World Journal of Transplantation2013，3，3： | 6 |
| 4 | 高危心血管病老年人血压变异性的相关因素显示文摘诊问血压变异性是心血管病的独立预测因素。该研究探讨老年人血压变异的相关因素。方法:在普伐他汀干预高危老年人的前瞻性研究( pravastatin inelderly individuals at risk of vascular disease, PROS-PER)中,分析70~82岁有心血管病史或危险因素的男性和女性者3794人。 | Poortvliet RK Lloyd SM Ford I Sattar N de Craen AJ Wijsman LW Mooijaart SP Westendorp G Jukema JW de Ruijter W Gussekloo J Stott DJ | 2015 | 中华高血压杂志2015，23，10： | 3 |
| 5 | The DNA-binding factor Ctcf critically controls gene expression in macrophages显示文摘巨噬细胞在免疫和动态平衡起一个重要作用。在经由特定的受体的病原体识别之上,他们很快导致煽动性的回答。这个过程紧在 transcriptional 水平被控制。DNA 有约束力的锌手指蛋白质 CCCTC 有约束力的因素(Ctcf ) 是远程的染色质相互作用的一个关键管理者并且协调在抄写因素和基因表达式进程之间的特定的通讯。在这研究, Ctcf 基因被使用转基因的 Cre-LoxP 系统明确地在 myeloid 房间删除。在 myeloid 房间的 Ctcf 基因的有条件的删除在 vivo 导致了温和显型。显著地展出的 Ctcf 缺乏的老鼠减少了主要 histocompatibility 的表示在肝的建筑群(MHC ) 班 II。Ctcf 缺乏的巨噬细胞表明了正常表面显型和吞噬作用能力。在像使用费的受体(TLR ) 之上刺激,他们生产了支持 inflammatory cytokines IL-12 和 IL-6 的正常层次,但是表明了一个强烈损害的能力生产肿瘤坏死因素(TNF ) 和 IL-10,以及表示 IL-10 家庭成员 IL-19, IL-20 和 IL-24。一起拿,我们的数据表明涉及巨噬细胞功能调整的 Ctcf 的一个角色。 | Tatjana Nikolic Dowty Movita Margaretha EH Lambers Claudia Ribeiro de Almeida] Paula Biesta Kim Kreefft Marjolein JW de Bruijn Ingrid Bergen Niels Galjart Andre Boonstra Rudi Hendriks | 2014 | Cellular & Molecular Immunology2014，11，1： | 2 |
| 6 | Ovarian germ cell tumors in children:a clinical study of 66 patients显示文摘 | De Backer A Madern GC Oosterhuis JW | 2006 | Pediatr Blood Cancer2006，46，6： | 1 |
| 7 | Laminin-binding integrins in rat lens morpho- genesis and their regulation during fibre differentiation显示文摘 | WedereU ED Brown H O' Connor M Chamberlain CG McAvoy JW de Iongh RU | 2005 | Exp Eye Res2005，81，3： | 1 |
| 8 | Increased uncouplingprotein-2 levels inβ-cells are associated with impaired glucose-stimulated insulin secretion:mechanism of action显示文摘 | Chan CB De Leo D Joseph JW | 2001 | Diabetes2001，50，： | 1 |
| 9 | Melanosis of the esophagus 显示文摘 | De la Pava S Nigogosyan G Pickren JW | 1963 | Cancer1963，16，： | 1 |
| 10 | Paracrine Hedgehog signalingin cancer 显示文摘 | Theunissen JW de Sauvage FJ | 2009 | Cancer Res2009，69，15： | 1 |
| 11 | Two-year statin therapy does not alter the progression of intima-media thickness in patients with type 2 diabetes without manifest cardiovascular disease显示文摘 | Beishuizen ED van de Ree MA Jukema JW el al | 2004 | Diabetes Care2004，27，12： | 1 |
| 12 | Microbial biafilms显示文摘 | Costerton JW Lewandowski Z Caldwell DE | 1995 | Annu Rev Microbiol1995，49，3： | 1 |
| 13 | Ureteroscopy: update on current practice and long termcomplications显示文摘 | Chow GK Blute ML Patterson DE Segura JW | 2001 | Urol2001，165，2： | 1 |
| 14 | Facial never grading system 显示文摘 | House JW Brackmann DE | 1985 | Otolaryngol Head Neck Surg1985，93，2： | 1 |
| 15 | Increased serum neuronspecific enolaseconcentrations in patients with hyperglycemic cortical ischemic stroke显示文摘 | Suiter G Elting JW De Keyser J | 1998 | Neurosci Lett1998，253，1： | 1 |
| 16 | Internal urethrotomy versus dilation as treatment for male urethral, strictures : A prospective, randomized comparison 显示文摘 | Steenkamp JW Heyns CF de Kock ML | 1997 | J Urol1997，157，1： | 1 |
| 17 | Excess mortality in women compared to men after PCI in STEMI: An anal- ysis of 11,931 patients during 2000-2009 显示文摘 | De Boer SP Roos-Hesselink JW van Leeuwen MA | 2014 | Int J Cardiol2014，176，2： | 1 |
| 18 | Facial never grading systems显示文摘 | House JW Brackmann DE | 1983 | Laryngoscope1983，93，： | 1 |
| 19 | Late side eftects ot short-course preoperative radiotherapy combined with total mesorectal excision for rectal cancer: increased bowel dysfunction in irradiated patients-a Dutch colorectal cancer group study 显示文摘 | Pceters KC van de Velde C J Leer JW | 2005 | J Clin Oncol2005，23，25： | 1 |
| 20 | Telomerase activity in normal and malignant hematopoietic cells 显示文摘 | Broccoli D Young JW de Lange T | 1995 | Proc Natl Acad Sci USA1995，92，20： | 1 |
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