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| 1 | 补体B因子是代谢综合征模型代谢与心血管特征的一个决定因素显示文摘补体B因子(complenment factor B,CFB)在2型糖尿病及心血管病患者脂肪组织及血清中水平升高,但与疾病发病机制的因果关系不明确。自发性高血压大鼠(spontaneously hypertensive rats,SHR)脂肪组织及血清中CFB也升高。为明确CFB在代谢综合征中的作用,研究者在SHR中敲除Cfb基因。 | 赵狄 练桂丽 Coan PM Barrier M Alfazema N Carter RN Marion de Procé S Dopico XC Garcia Diaz A Thomson A Jackson-Jones LH Moyon B Webster Z Ross D Moss J Arends MJ Morton NM Aitman TJ | 2017 | 中华高血压杂志2017，25，8： | 3 |
| 2 | Current status and prospects of clinical proteomics studies on detection of colorectal cancer:Hopes and fears显示文摘Colorectal adenocarcinoma (CRC) is the third most com-mon type of cancer and the fourth most frequent cause of death due to cancer worldwide. Given the natural history of CRC, early diagnosis appears to be the most appropriate tool to reduce disease-related mortality. A fi eld of recent interest is clinical proteomics, which was reported to lead to high sensitivity and specifi cities for early detection of several solid tumors. This emerging fi eld uses mass spectrometry-based protein profi les/pat-terns of easy accessible body fluids to distinguish cancer from non-cancer patients. These discrepancies may be a result of: (1) proteins being abnormally produced or shed and added to the serum proteome, (2) proteins clipped or modified as a consequence of the disease process, or (3) proteins subtracted from the proteome owing to disease-related proteolytic degradation path-ways. Therefore, protein pattern diagnostics would pro-vide easy and reliable tools for detection of cancer. This paper focuses on the current status of clinical proteomics research in oncology and in colorectal cancer especially, and will re? ect on pitfalls and fears in this relatively new area of clinical medicine, which are reproducibility issues and pre-analytical factors, statistical issues, and identifi -cation and nature of discriminating proteins/peptides. | ME de Noo RAEM Tollenaar AM Deelder LH Bouwman | 2006 | World Journal of Gastroenterology2006，12，41： | 3 |
| 3 | Magnetic resonance imaging of cartilaginous tumors:a retrospective study of 79 patients显示文摘 | De Beuckeleer LH De Schepper AM Ramon F | 1995 | Eur J Radiol1995，21，1： | 1 |
| 4 | Reduced Risk of Tuberculosis among Brazilian Patients with Advanced Human Immunodeficiency Virus Infection Treated with Highly Active Antiretroviral Therapy 显示文摘 | Santoro Lopes G De Pinho AM Harrison LH | 2002 | Clin Infect Dis2002，34，： | 1 |
| 5 | Genetic polymorphism of thiopurine S-methyltransferase in Argentina显示文摘 | de Kremer RD Lambooy LH | 2003 | Ann Clin Biochem2003，40，4： | 1 |
| 6 | Stem cell factor receptor (c-KIT) codon 816 mutations predict development of bilateral testicular germ-cell tumors显示文摘 | Looijenga LH de Leeuw H van Oorschot M | 2003 | Cancer Res2003，63，22： | 1 |
| 7 | Gemcit- abine and cisplatin salvage regimen in heavily pretreated meta- static breast cancer: a Brazilian experience 显示文摘 | de Lima Arat:jo LH Moitinho MV Silva AM | 2011 | Med Oncol2011，28，1： | 1 |
| 8 | Breast cancer resis-tance protein in drug resistance of primitive CD34+38-cells in acutemyeloid leukemia显示文摘 | Raaijmakers MH de Grouw EP Heuver LH | 2005 | Clin Cancer Res2005，11，6： | 1 |
| 9 | Chemotherapy response evaluation with FDG-PET in patients with colorectal cancer显示文摘 | De GO Van LH Visser EP | 2008 | Ann Oncol2008，19，2： | 1 |
| 10 | A delphi study of self-cure in a community population of peoplee with multiple-sclerosis显示文摘 | DE SOUZA LH IDEL | 2000 | Clinleal Rehabilitatbn2000，14，1： | 1 |
| 11 | Breast cancer resistance protein in drug resistance of primitive CD 34 + 38 - cells in acute myeloid leukemia 显示文摘 | Raaijmakers MH de Grouw EP Heuver LH | 2005 | Clin Cancer Res2005，11，6： | 1 |
| 12 | A new risk scheme to predict ischemic stroke and other thromboembolism in atrial fibrilla- tion: The ATRIA study stroke risk score 显示文摘 | Singer DE Chang Y Borowsky LH | 2013 | J Am Heart Assoc2013，2，00： | 1 |
| 13 | Comorbidity and colorectal cancer according to subsite andstage: a population-based study 显示文摘 | De Marco M F Janssen-Heijnen M L van der Heijden LH | 2000 | Eur J Cancer2000，36，1： | 1 |
| 14 | Desmoplastic Fibroma of Bone:MRI Features显示文摘 | Vanhoenacker FM Hauben E De Beuckeleer LH | 2000 | Skeletal Radiol2000，29，1： | 1 |
| 15 | POU5F1 (OCT3/4)identifies cells with pluripotent potential in human germ cell tumors显示文摘 | Looijenga LH Stoop H De Leeuw HP | 2003 | Cancer Res2003，63，9： | 1 |
| 16 | Fat feeding causeswidespread in vivo insulin resistance , decreased energyexpenditure , andobesity in rats显示文摘 | Storlien LH James DE Burleigh KM | 2006 | Am J Physiol2006，251，： | 1 |
| 17 | Low -grade chondrosarcoma vs enchondroma: challenges in diagnosis and management 显示文摘 | Wang XL De Beuckeleer LH De Schepper AM | 2001 | Eur Radiol2001，6，： | 1 |
| 18 | Effects of moderate weight loss and orlistat on insulin resistance, regional adiposity, and fatty acids in type 2 diabetes显示文摘 | Kelley DE Kuller LH McKolanis TM | 2004 | Diabetes Care2004，7，1： | 1 |
| 19 | Relationships of mortality with the fine and coarse fractions of long-term ambient PMI0 concentrations in nonsmokers 显示文摘 | McDonnell WF Nishino-Ishikawa N Petersen FF Chen LH Abbey DE | 2000 | J Expo Anal Environ Epidemiol2000，10，5： | 1 |
| 20 | Respiration and ethylene production by kiwifruit following hot water dips显示文摘 | Irving DE Pallesen JC Cheah LH | 1991 | Postharvest Biology and Technology1991，1，： | 1 |
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