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| 1 | 腹壁疝补片修补相关感染:病理学、治疗和结局显示文摘目的分析应用合成补片行疝修补后出现需要去除补片的手术部位感染并发症病人的临床及人口统计学特点,补片植入手术的细节以及感染发生后的治疗和结局。方法从病人资料表中获得病人的感染相关因素(人口统计学参数、疝修补术特点和使用的网片)。收集32例连续病例的标本(补片和组织),行细菌培养和显微镜检查。前瞻性评估补片取出后的结局。结果 22例接受了切口疝修补术,10例接受了腹股沟疝修补术,大部分病人手术时间较长,28例出现过早期伤口并发症(浆液肿或血肿)。在'补片植入-取出'间期,部分病人进行了保守治疗,例如局麻下引流或者窦道切除。22例的网片被完全取出(其中9例是补片部分取出后),其余10例部分取出补片治疗有效。大部分补片(24例)是多纤丝聚丙烯网片,补片周围组织的显微镜观察发现有白细胞浸润、巨细胞反应、胶原纤维无序排列以及脓肿形成。32例共进行了51例次手术治疗,补片取出后,有6例复发和2例肠瘘。平均随访时间为40(30~97)个月。结论大多数需要去除补片的感染病例前次疝修补术时间较长,并且有未经治疗的术后早期伤口并发症。补片部分取出通常不会成功,而且会带来并发症。取出全部补片的外科探查手术应该在全麻下进行。 | Tolino MJ Tripoloni DE Ratto R Garcia MI | 2010 | 中国实用外科杂志2010，30，12： | 20 |
| 2 | 美国家族性高胆固醇血症或其他严重血脂异常患者的胆固醇筛查、疾病认知和他汀类药物治疗的情况与预测因子(1999-2014)显示文摘家族性高胆固醇血症(familial hypercholesterolemia,FH)和其他低密度脂蛋白胆固醇的极度升高显著增加动脉粥样硬化性心血管病风险;然而,最近的数据表明,他汀类药物的处方率在这些患者中仍然很低。FH或严重血脂异常者的筛查率、知晓率和他汀治疗率尚不清楚。 | 刘青 叶鹏 Bucholz EM Rodday AM Kolor K Khoury MJ de Ferranti SD | 2018 | 中华高血压杂志2018，26，5： | 5 |
| 3 | 补体B因子是代谢综合征模型代谢与心血管特征的一个决定因素显示文摘补体B因子(complenment factor B,CFB)在2型糖尿病及心血管病患者脂肪组织及血清中水平升高,但与疾病发病机制的因果关系不明确。自发性高血压大鼠(spontaneously hypertensive rats,SHR)脂肪组织及血清中CFB也升高。为明确CFB在代谢综合征中的作用,研究者在SHR中敲除Cfb基因。 | 赵狄 练桂丽 Coan PM Barrier M Alfazema N Carter RN Marion de Procé S Dopico XC Garcia Diaz A Thomson A Jackson-Jones LH Moyon B Webster Z Ross D Moss J Arends MJ Morton NM Aitman TJ | 2017 | 中华高血压杂志2017，25，8： | 3 |
| 4 | Auto immune hepatitis显示文摘To provide an update of the latest trends in epidemiology, clinical course, diagnostics, complications and treatment of auto immune hepatitis(AIH). A search ofthe MEDLINE database was performed using the search terms: 'auto immune hepatitis', 'clinical presentation', 'symptoms', 'signs', 'diagnosis', 'auto antibodies', 'laboratory values', 'serology', 'histopathology', ' h i s t o l o g y ', ' g e n e t i c s ', 'HLA g e n e s ', 'non-HLA genes', 'environment', 'epidemiology', 'prevalence', 'incidence', 'demographics', 'complications', 'HCC', 'PBC', 'PSC', 'corticosteroid', 'therapy', 'treatment', 'alternative treatment'. English-language full-text articles and abstracts were considered. Articles included reviews, meta-analysis, prospective retrospective studies. No publication date restrictions were applied. AIH is an immune meditated progressive inflammatory liver disease that predominantly affects middle-aged females but may affect people of all ages. The clinical spectrum of AIH is wide, ranging from absent or mild symptoms to fulminant hepatic failure. The aetiology of AIH is still unknown, but is believed to occur as the consequence of an aberrant immune response towards an un-known trigger in a genetically susceptible host. In the absence of a gold standard, diagnosis is based on the combination of clinical, biochemical and histopathological criteria. Immunosuppressive treatment has been the cornerstone of treatment since the earliest description of the disease in 1950 by Waldenstr?m. Such treatment is often successful at inducing remission and generally leads to normal life expectancy. Nevertheless, there remain significant areas of unmet aetiological a clinical needs including fundamental insight in disease pathogenesis, optimal therapy, duration of treatment and treatment alternatives in those patients unresponsive to standard treatment regimens. | nicole mf van gerven ynto s de boer chris jj mulder carin mj van nieuwkerk gerd bouma | 2016 | World Journal of Gastroenterology2016，22，19： | 3 |
| 5 | Long-term benefi t of primary angioplasty as compared with thrombolytic therapy for acute myocardial infarction显示文摘 | Zijlstra F Hoorntje JC de Boer MJ | | the New England Journal of Medicine0，，： | 2 |
| 6 | Identification of atherosclerotic plaque components with intravascular ultrasound elastography in vivo: a Yucatan pig study显示文摘 | de Korte CL Sierevogel MJ Mastik F | 2002 | Circulation2002，105，14： | 2 |
| 7 | Quality of life in patients with anorectal malformations or hirschsprung's disease:the development of a disease-specific questionnaire显示文摘 | Hanneman MJ Sprangers MA De Mik EL | 2001 | Dis Colon Rectum2001，44，： | 1 |
| 8 | Genome remodelling in a basal-like breast cancer metastasis and xenograft显示文摘 | Ding L Ellis MJ Li S Larson DE | 2010 | Nature2010，464，7291： | 1 |
| 9 | Aneurysmal bone cyst:concept,contro-versries,patient presentation ,and imaging显示文摘 | Kransdorf MJ Sweet DE | 1995 | AJR1995，164，： | 1 |
| 10 | Open source clustering software显示文摘 | De Hoon MJ Imoto S Nolan J | 2004 | Bioinformat2004，20，9： | 1 |
| 11 | Enhanced accumu-lation of Pb in Indian mustard by soil-applied chelating ugents显示文摘 | Blaylock MJ Sait DE DushenkovS | 1997 | Environmental Science and Technology1997，31，： | 1 |
| 12 | Pathologist variation in reporting cervical borderline epithelial abnormalities and cervical intraepithelial neoplasia显示文摘 | Creagh T Bridger JE Kupek E Fish DE Martin-Bates E Wilkins MJ | 1995 | J Clin Pathol1995，48，1： | 1 |
| 13 | Chronic active Epstein-Barr virus infection in an adult with no detectable immune deficiency 显示文摘 | de Boer M Mol MJ Bogman MJ | 2003 | Neth J Med2003，61，11： | 1 |
| 14 | Development andqualification of the parallel line model for the estimation of humaninfluenza haemagglutinin content using the single radial immunod-iffusion assay显示文摘 | Van Kessel G Geels MJ De Weerd S | 2012 | Vaccine2012，30，2： | 1 |
| 15 | Exacerbation of chronic hepatitis B infection after delivery显示文摘 | Ter Borg MJ Leemans WF De Man RA | 2008 | Journal of Viral Hepatitis2008，15，1： | 1 |
| 16 | Development of a selective culture medium for primary isolation of the main Brucella species 显示文摘 | De Miguel MJ Marin CM Munoz PM | 2011 | J Clin Microbio12011，49，： | 1 |
| 17 | A gene-expression signature as a predictor of survival in breast cancer显示文摘 | van de Vijver MJ He YD van't Veer LJ | 2002 | N Engl j Med2002，347，25： | 1 |
| 18 | Alzheiner's disease显示文摘 | BLENNOW K DE LEON MJ ZETTERBERG H | 2006 | Lancet2006，368，9533： | 1 |
| 19 | Oxidative stress and apoptosis are induced in human endothelial cells exposed to urban particulate matter显示文摘 | Montiel-D(lvalos A de Ibarra-S(lnchez MJ Ventura- Gallegos JL | 2010 | Toxico] in Vitro2010，24，1： | 1 |
| 20 | Trends in life expectancy after hal cord injury显示文摘 | Strauss DJ De Vivo MJ Paculdo DR | 2006 | Arch Phys Med Rehabil2006，87，10： | 1 |
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