|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Improving the outcomes in gastric cancer surgery显示文摘Gastric cancer remains a significant health problem worldwide and surgery is currently the only potentially curative treatment option. Gastric cancer surgery is generally considered to be high risk surgery and fiveyear survival rates are poor,therefore a continuous strive to improve outcomes for these patients is warranted. Fortunately,in the last decades several potential advances have been introduced that intervene at various stages of the treatment process. This review provides an overview of methods implemented in pre-,intra- and postoperative stage of gastric cancer surgery to improve outcome. Better preoperative risk assessment using comorbidity index(e.g.,Charlson comorbidity index),assessment of nutritional status(e.g.,short nutritional assessment questionnaire,nutritional risk screening- 2002) and frailty assessment(Groningen frailty indicator,Edmonton frail scale,Hopkins frailty) was introduced. Also preoperative optimization of patients using prehabilitation has future potential.Implementation of fast-track or enhanced recovery after surgery programs is showing promising results,although future studies have to determine what the exact optimal strategy is.Introduction of laparoscopic surgery has shown improvement of results as well as optimization of lymph node dissection.Hyperthermic intraperitoneal chemotherapy has not shown to be beneficial in peritoneal metastatic disease thus far.Advances in postoperative care include optimal timing of oral diet,which has been shown to reduce hospital stay.In general,hospital volume,i.e.,centralization,and clinical audits might further improve the outcome in gastric cancer surgery.In conclusion,progress has been made in improving the surgical treatment of gastric cancer.However,gastric cancer treatment is high risk surgery and many areas for future research remain. | Juul JW Tegels Michiel FG De Maat Karel WE Hulsewé Anton GM Hoofwijk Jan HMB Stoot | 2014 | World Journal of Gastroenterology2014，20，38： | 16 |
| 2 | Induction of cytotoxic T lymphocyte respones in vivo after immunotherapy with dendritic cells in patients with nasopharyngeal carcinoma显示文摘The aim of the present study was to determine the efficacy of immunotherapy with dendritic cells to elicit EBV-specific CTL-immunity in advanced cases of EBV-positive patients with nasopharyngeal carcinoma (NPC) and to determine the safety and toxicity of this preparation. Nine cases of histologically confirmed patients with NPC undergoing treatment with radiological therapy were enrolled in this study. Dendritic cells, generated in vitro from blood monocytes of patients were cultured and matured with cytokines and then infected with recombinant adenovirus vaccine containing EBV-latent membrane protein-2 (Ad-LMP2). On 9 days' cultivation of cells, the matured DCs were harvested, irradiated with Co and then injected intradermally to patients with NPC. The injections were performed 3 times totally. After immunization, the CTL responses were assayed by means of cytotoxicity and epitope-specific IFN-γproduction. The results of this trial showed that all patients could tolerate this kind of treatment without any side effect, during which marked increase of LMP2-specific CTL-responses could be demonstrated in 5 patients of this group. And the level of IgA/VCA antibody decreased in 8 of 9 patients, thus accounting for a better prognosis for these patients. All patients will be followed up for another one year. At least, the present work shows that intradermal vaccination with autologous DCs infected with recombinant Ad-LMP2 adenovirus is a safe procedure in NPC patients, in which this procedure can enhance the LMP2-specific CTL responses in patients. These data are encouraging to develop more effective vaccine strategies for the treatment of nasopharyngeal carcinoma. | JIAN MIN ZUO LING ZHOU ZHI JIAN CHEN DE RUI LI QI WANG JIONG YU CHEN ZHAN WANG SI-IU QING WE YI ZENG | 2006 | Journal of Microbiology and Immunology2006，4，1： | 7 |
| 3 | Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy显示文摘 | Cooper ME De Zeeuw D Keane WF Mitch WE Parving H-H | 2001 | N Engl J Med2001，345，12： | 1 |
| 4 | Performance characterisitics of an automated high-sensitivity C-reactive protein assay on the dimension RXL analyzer显示文摘 | De BK Smith LG Owen WE | 2002 | Clin Chem Acta2002，323，： | 1 |
| 5 | Intrapatient comparion of restenosis between carotid artery angioplasty with stenting and carotid endarterectomy显示文摘 | De Borst GJ Hellings WE Ackerstaff RG | 2006 | J Cardiovasc Surg2006，47，1： | 1 |
| 6 | Treatment for extend- ed-mid and distal ureteral stones:SWL or ureteroscopy? Results o显示文摘 | Hendrikx AJ Strijbos WE de Knijff DW | 1999 | J Endourol1999，13，10： | 1 |
| 7 | Flexion and rota- tion of the trunk and lifting at work are risk factors for low back pain resuhs of a prospective cohort study 显示文摘 | Hoogendoorn WE Bongers PM de Vet HC | 2000 | Spine2000，25，23： | 1 |
| 8 | Dysphagia and lung aspi-ration secondary to anterior cervical osteophytes:a case reportand review of the literature显示文摘 | De Jesus-Monge WE Cruz-Cuevas EI | | 0，，2： | 1 |
| 9 | Anatomical basis of autonomic nerve-preserving total nesorectal excision for rectal cancer 显示文摘 | Havenga K De Ruiter MC Enker WE | 1996 | Br J Surg1996，83，4： | 1 |
| 10 | Modern chromatographic analysis of the vitamins显示文摘 | Bui-Nguym MH Leenheer De Lambert WE | 1985 | New York:Marcel Dekker1985，48，： | 1 |
| 11 | Report of 190 consecutive case of large acoustic tumors (vestibular schwannoma) removed via the translabyrinthine approach 显示文摘 | Lanman TH Brackmann DE Hitselberger WE | 1999 | J Neurosurg1999，90，4： | 1 |
| 12 | A human mono- clonal antibody cocktail as a novel component of rabies pos- texposure prophylaxis显示文摘 | de Kruif J Bakker AB Marissen WE | 2007 | Annu Rev Med2007，58，： | 1 |
| 13 | Changes in L-selection expression on CD34-positive cells upon cryopreservation of peripheral blood stem cell transplants显示文摘 | Drager AM van der WE | 1998 | Bone Marrow Transplant1998，22，： | 1 |
| 14 | Anatomical basis of autonomic nerve preserving-total mesorectal excision for rectal cancer显示文摘 | Havenga K de Ruitter MC Enker WE | 1996 | Br J Surg1996，83，3： | 1 |
| 15 | Anatomical basis of autonomic nerve-preserving total mesorectal excision for rectal cancer显示文摘 | HAVENGA K DE RUITER MC ENKER WE | 1996 | Br J Surg1996，83，4： | 1 |
| 16 | Thoracopy talc poudrage:a 15-year experience显示文摘 | Vargas FS De Campos WE | 2001 | Chest2001，119，3： | 1 |
| 17 | Liquidchromatographic measurement of riboflavin in serum and urine with isoriboflavin as internal standard显示文摘 | Lambert WE Cammaert PM De Leenheer AP | | Clin Chem0，31，： | 1 |
| 18 | Carotid atherosclerotic plaques stabilize after stroke:insights into the natural process of atherosclerotic plaque stabilization显示文摘 | Peeters W Hellings WE de Kleijn DP | 2009 | Arterioscler Thromb Vasc Biol2009，29，1： | 1 |
| 19 | Xeroderma pigmento- sum group F caused by a defect in a structure-specific DNA re- pair endonuclease显示文摘 | Sijbers AM de Laat WE Ariza RR | 1996 | Cell1996，86，5： | 1 |
| 20 | Opportunities and challenges for mesenchymal stem cell-mediated heart repair 显示文摘 | Atsma DE Fibbe WE Rabelink TJ | 2007 | Curr Opin Lipidol2007，18，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员