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| 1 | Methylation of TIMP3 in esophageal squamous cell carcinoma显示文摘AIM: To measure the frequency of DNA methylation of the tissue inhibitor of metalloproteinase 3 (TIMP3) promoter and relate this to any change of gene expression in esophageal squamous cell carcinoma in patients from a region of high incidence in China.METHODS: Cancer cell lines were treated with or without the demethylating reagent 5-aza-2’-deoxycytidine. Methylation of the TIMP3 promoter was assessed in three regions by melt curve analysis and its expression was assessed by real-time RT-PCR. Tumors and proximal resection margins were obtained from 64 patients with esophageal squamous cell carcinoma from a region of high incidence in China. Methylation was assessed by melt curve analysis and expression by immunohistochemistry.RESULTS: Methylation in one of the three promoter regions assessed correlated with gene silencing in esophageal cell lines. A degree of methylation of TIMP3 was found in only four esophageal squamous cell carcinomas, and partial loss of TIMP3 protein expression in just one.CONCLUSION: Methylation and loss of expression of TIMP3 occurs infrequently in esophageal squamous cell carcinoma in a region of high incidence in China. | Eric Smith Neville J De Young Zi-Qiang Tian Maria Caruso Andrew R Ruszkiewicz Jun-Feng Liu Glyn G Jamieson Paul A Drew | 2008 | World Journal of Gastroenterology2008，14，2： | 2 |
| 2 | Intraoperative stimulation of pedicle sctews:A new method for verification of screw placement显示文摘 | Young WF Morledge DE Martin W | 1995 | Surg Neurol1995，44，： | 1 |
| 3 | Hyperglycemia cerebrospinal fluid lactic acidosis, and cerebral blood flow in severely head injured patients 显示文摘 | De Salles AA Muizelaar JP Young HF | 1987 | Neurosurg1987，21，1： | 1 |
| 4 | Methylation of CLDN6,FBN2,RBP1,RBP4,TFPI2,and TMEFF2 in esophageal squamous cell carcinoma显示文摘 | Tsunoda S Smith E De Young NJ | 2009 | Oncol Rep2009，21，4： | 1 |
| 5 | Telomerase activity in normal and malignant hematopoietic cells 显示文摘 | Broccoli D Young JW de Lange T | 1995 | Proc Natl Acad Sci USA1995，92，20： | 1 |
| 6 | p21 expression predicts outcome in p53-null ovarian carcinoma显示文摘 | Rose SL Goodheart MJ De Young BR | 2003 | Clin Cancer Res2003，9，3： | 1 |
| 7 | Beta defensin-1, parvalbumin, and vimentin: a panel of diagnostic immunohisto- chemical markers for renal tumors derived from gene expression profiling studies using cDNA mieroarrays 显示文摘 | Young AN de Oliveira Salles PG Lim SD | 2003 | Am J Surg Pathol2003，27，2： | 1 |
| 8 | Edema and cell infiltration in the phorbol ester-treated mouse ear are temporally separate and can be differentially modulated by pharmacologic agents显示文摘 | De Young LM Kheifets JB BaUaron SJ | 1989 | Agents Actions1989，26，34： | 1 |
| 9 | Associations between changes in physical activity and risk factors for coronary heart disease in a community based sample of men and women:The Stanford Five-city project显示文摘 | YOUNG DR HASKELL WL JATULIS DE | 1993 | Am J Epidemic1993，13，8： | 1 |
| 10 | Exploring the Differences Between Recyclers and Non-Recyclers:The Role of Information显示文摘 | | 1989 | Journal of Environmental Systems1989，18，4： | 1 |
| 11 | A new potassium channel toxin from the sea anemone Heteractis magnificaz isolation, eDNA cloning, and functional expression显示文摘 | GENDEH G S YOUNG L C DE MEDEIROS L C | 1997 | Biochemistry1997，36，11： | 1 |
| 12 | Lineage choice and differentiation in mouse embryos and embryonic stem cells显示文摘 | Loebel DA Watson CM de Young RA | 2003 | Dev Biol2003，264，1： | 1 |
| 13 | Recipient T cells mediate reperfusion injury after lung transplantation in the rat显示文摘 | de Perrot M Young K Imai Y | | 0，，10： | 1 |
| 14 | Body composition and protein and fat accretion in various body components in growing gilts fed diets with different protein levels but estimated to contain similar levels of ideal protein显示文摘 | TUITOEK J K YOUNG L G de LANGE C F M | 1997 | J Anim Sci1997，75，： | 1 |
| 15 | Methylation of CLDN6, FBN2, RBP1, RBPd, TFPI2, and TMEFF2 in esophageal squa- mous cell carcinoma显示文摘 | Tsunoda S Smith E De Young NJ | 2009 | Oncol Rep2009，21，4： | 1 |
| 16 | Agonists of proteinase-activated receptor 1 induce plasma extravasation by a neurogenic mechanism显示文摘 | De Garavilla L Vergnolle N Young SH | 2001 | Br J Pharmacol2001，133，7： | 1 |
| 17 | Sorafenib in radioactive iodine-refractory, locally advanced or metastatic differentiated thyroid cancer: a randomised, double-blind, phase 3 trial显示文摘 | Marcia S Brose Christopher M Nutting Barbara Jarzab Rossella Elisei Salvatore Siena Lars Bastholt Christelle de la Fouchardiere Furio Pacini Ralf Paschke Young Kee Shong Steven I Sherman Johannes W A Smit John Chung Christian Kappeler Carol Pe?a István Mo | 2014 | The Lancet2014，，： | 1 |
| 18 | Large - scale double - staining of rat fetal skeletons using Alizarin Red S and Alcian Blue显示文摘 | Young AD Phipps DE Astroff AB | 2000 | Teratology2000，61，4： | 1 |
| 19 | Recipient T cells mediate reperfusion injury after lung transplantion in the rat显示文摘 | de Perrot M Young K Imai Y | 2003 | J Immuno12003，171，10： | 1 |
| 20 | Placental characteristics of selective birth weight discordance in diamniotic-monochorionic twin gestations显示文摘 | De Paepe ME Shapiro S Young L | 2010 | Placenta2010，31，5： | 1 |
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