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| 1 | MicroRNAs and immunity in periodontal health and disease显示文摘MicroRNAs(miRNAs) are critical regulators of the host immune and inflammatory response against bacterial pathogens. In the present review, we discuss target genes, target gene functions, the potential regulatory role of miRNAs in periodontal tissues, and the potential role of miRNAs as biomarkers and therapeutics. In periodontal disease, miRNAs exert control over all aspects of innate and adaptive immunity, including the functions of neutrophils, macrophages, dendritic cells and T and B cells. Previous human studies have highlighted some key miRNAs that are dysregulated in periodontitis patients. In the present study, we mapped the major miRNAs that were altered in our reproducible periodontitis mouse model relative to control animals. The miRNAs that were upregulated as a result of periodontal disease in both human and mouse studies included miR-15 a, miR-29 b, miR-125 a, miR-146 a,miR-148/148 a and miR-223, whereas miR-92 was downregulated. The association of individual miRNAs with unique aspects of periodontal disease and their stability in gingival crevicular fluid underscores their potential as markers for periodontal disease progression or healthy restitution. Moreover, miRNA therapeutics hold great promise for the future of periodontal therapy because of their ability to modulate the immune response to infection when applied in conjunction with synthetic antagomirs and/or relatively straightforward delivery strategies. | Xianghong Luan Xiaofeng Zhou Afsar Naqvi Marybeth Francis Deborah Foyle Salvador Nares Thomas G.H.Diekwisch | 2018 | International Journal of Oral Science2018，10，3： | 10 |
| 2 | The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase显示文摘 | Thomas F Franke Sung-Il Yang Tung O Chan Ketaki Datta Andrius Kazlauskas Deborah K Morrison David R Kaplan Philip N Tsichlis | 1995 | Cell1995，，5： | 2 |
| 3 | A Controlled Trial of Gluten-Free Diet in Patients With Irritable Bowel Syndrome-Diarrhea: Effects on Bowel Frequency and Intestinal Function显示文摘 | Maria I. Vazquez–Roque Michael Camilleri Thomas Smyrk Joseph A. Murray Eric Marietta Jessica O’Neill Paula Carlson Jesse Lamsam Denise Janzow Deborah Eckert Duane Burton Alan R. Zinsmeister | 2013 | Gastroenterology2013，，5： | 2 |
| 4 | Assessment of Value and Applications of In Vitro Testing of Topical Dermatological Drug Products显示文摘 | Gordon L. Flynn Vinod P. Shah Srinivas N. Tenjarla Michael Corbo David DeMagistris Terry G. Feldman Thomas J. Franz Deborah R. Miran David M. Pearce Joel A. Sequeira James Swarbrick Jonas C. T. Wang Avaraham Yacobi Joel L. Zatz | 1999 | Pharmaceutical Research1999，，9： | 2 |
| 5 | Sterile Filtration of a Parenteral Emulsion显示文摘 | Deborah M. Lidgate Thomas Trattner Richard M. Shultz Richard Maskiewicz | 1992 | Pharmaceutical Research1992，，7： | 1 |
| 6 | Nitrogen fixationand leaching of biological soil crust communities in mesictemperate soils显示文摘 | Roberta MV Deborah AN Thomas RW | 2006 | Microbial Ecology2006，51，2： | 1 |
| 7 | Crash and Occupant Predictors of Pulmonary Contusion显示文摘 | James V. O’Connor Joseph A. Kufera Timothy J. Kerns Deborah M. Stein Shiu Ho Patricia C. Dischinger Thomas M. Scalea | 2009 | The Journal of Trauma: Injury, Infection, and Critical Care2009，，4： | 1 |
| 8 | Post - traumatic stress symptoms in an elite unit of Brazilian police of- ricers: Prevalence and impact on psychosocial functioning and on physical and mental health 显示文摘 | Deborah B Maia Charles R Marmar Thomas Metzler | 2007 | Journal of Affective Disorders2007，97，13： | 1 |
| 9 | Entecavir is superior to lamivudine in reducing hepatitis B virus DNA in patients with chronic hepatitis B infection显示文摘 | Ching–Lung Lai Mohamed Rosmawati Judy Lao Hans Van Vlierberghe Frank H. Anderson Neal Thomas Deborah Dehertogh | 2002 | Gastroenterology2002，，6： | 1 |
| 10 | Aliskiren-based therapy lowers blood pressure more effectively than hydrochlorothiazide-based therapy in obese patients with hypertension: sub-analysis of a 52-week, randomized, double-blind trial显示文摘 | Roland E Schmieder Thomas Philipp Javier Guerediaga Manuel Gorostidi Christopher Bush Deborah L Keefe | 2009 | Journal of Hypertension2009，，7： | 1 |
| 11 | Epigenetics of Acute Lymphocytic Leukemia显示文摘 | Guillermo Garcia-Manero Hui Yang Shao-Qing Kuang Susan O’Brien Deborah Thomas Hagop Kantarjian | 2009 | Seminars in Hematology2009，，1： | 1 |
| 12 | Post - traumatic stress symptoms in an elite unit of Brazilian policeofficers : Prevalence and impact on psychosocial functioning and onphysical and mental health 显示文摘 | Deborah B MaiayCharles R Marmar Thomas Metzler | 2007 | Journal of Affective Disorders2007，97，13： | 1 |
| 13 | Double Unrelated Reduced-Intensity Umbilical Cord Blood Transplantation in Adults显示文摘 | Karen K. Ballen Thomas R. Spitzer Beow Y. Yeap Steven McAfee Bimalangshu R. Dey Eyal Attar Richard Haspel Grace Kao Deborah Liney Edwin Alyea Stephanie Lee Corey Cutler Vincent Ho Robert Soiffer Joseph H. Antin | 2007 | Biology of Blood and Marrow Transplantation2007，，1： | 1 |
| 14 | Tandem mass spectrometric analysis for amino, organic, and fatty acid disorders in newborn dried blood spots, a two - year summary, from the New England Newborn Screening Program 显示文摘 | Thomas HZ Eileen FF Deborah M | 2001 | Clin Chem2001，47，11： | 1 |
| 15 | Stroke Prevention in Atrial Fibrillation:Current Strategies and Recommendations显示文摘Stroke is the most common complication of atrial fibrillation(AF).Guidelines recommend anticoagulant treatment in patients with CHA2DS2VASc scores of>2.Registry data suggests that almost half of patients who should be on therapeutic anticoagulation for stroke prevention in AF(SPAF)are not.Warfarin and more recently developed agents,the'novel anticoagulants'(NOACs)reduce the risk of embolic strokes.In addition,the NOACs also reduce intracranial hemorrhage(ICH)by over 50% compared to warfarin.Anticoagulation and bridging strategies involving cardioversion,catheter ablation,and invasive/surgical procedures are reviewed.The development of reversal agents for NOACs and the introduction of left atrial appendage occluding devices will evolve the use of newer strategies for preventing stroke in high risk AF patients. | Gerald V.Naccarelli,MD Gregory Caputo,MD Thomas Abendroth,MD Samuel Faber,MD Mauricio Sendra-Ferrer,MD Deborah Wolbrette,MD Soraya Samii,MD,PhD Sarah Hussain,MD Mario Gonzalez,MD | 2016 | Cardiovascular Innovations and Applications2016，，B02： | 1 |
| 16 | Chemoimmunotherapy with a modified hyper-CVAD and rituximab regimen improves outcome in de novo Philadelphia chromosome-negative precursor B-Lineage acutelymphoblastic leukemia显示文摘 | Deborah A Thomas Susan O'Brien Stefan Faderl | 2010 | J Clin Oncol2010，28，24： | 1 |
| 17 | Patient Genotypes Impact Survival After Surgery for Isolated Congenital Heart Disease显示文摘 | Daniel Seung Kim Jerry H. Kim Amber A. Burt David R. Crosslin Nancy Burnham Donna M. McDonald-McGinn Elaine H. Zackai Susan C. Nicolson Thomas L. Spray Ian B. Stanaway Deborah A. Nickerson Mark W. Russell Hakon Hakonarson J. William Gaynor Gail P. Jarvik | 2014 | The Annals of Thoracic Surgery2014，，： | 1 |
| 18 | Photographer preference or image purpose? An investigation of posing bias in mammalian and non-mammalian species显示文摘 | Nicole A. Thomas Jennifer A. Burkitt Deborah M. Saucier | 2006 | Laterality: Asymmetries of Body Brain and Cognition2006，，4： | 1 |
| 19 | Vertebroplasty comparing injectable calcium phosphate cement compared with polymethylmethacrylate in a unique canine vertebral body large defect model显示文摘 | Thomas M. Turner Robert M. Urban Kern Singh Deborah J. Hall Susan M. Renner Tae-Hong Lim Michael J. Tomlinson Howard S. An | 2008 | The Spine Journal2008，，3： | 1 |
| 20 | Glycemic control after 6 days of insulin pump reservoir use in type 1 diabetes: Results of double‐blind and open‐label cross‐over trials of insulin lispro and insulin aspart 1型糖尿病患者连续使用胰岛素泵6天后的血糖控制情况:赖脯胰岛素与门冬胰岛素的双盲、开放标签、交叉试验显示文摘 | William V. Tamborlane Eric Renard R. Paul Wadwa Thomas Blevins Scott J. Jacober Rong Liu Deborah N. D’Souza Tina M. Rees | 2015 | Journal of Diabetes2015，，： | 1 |
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