|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 子宫内膜异位症妇女月经期腹膜及子宫内膜生物学相关细胞因子和生长因子的基因表达增加显示文摘Objective: To examine differential messenger RNA(mRNA)-expression of relevant cytokines, metalloproteases, growth and adhesion factors in endometrium and peritoneum from women with endometriosis when compared with women without the disease duringmenstrual and luteal phases of the cycle. Design: Patients with endometriosis were compared with control patients. Setting: University hospital. Patient(s): A total of 35 patients(20 patients during the luteal phase and 15 patients during the menstrual phase)were selected for this study on the basis of cycle phase and presence or absence of endometriosis. Intervention( s): In this study, endometriosis was laparoscopically and histologically confirmed in 24 women with endometriosis of revised American Society for Reproductive Medicine(ASRM) stage I-II(n=12) and revised ASRM stage III-IV(n=12), and the presence of a normal pelvis was documented by laparoscopy in 11 control patients. The macroscopically normal peritoneum tissues were collected from lateral wall left or right, near the colon ascendens or descendens. Main Outcome Measure(s): The expression levels were determined as ratios between the target molecules and β-actin as housekeeping gene. Result(s): In women with endometriosis, peritoneal mRNA levels of matrix metalloproteinase(MMP)-3, transforming growth factor-β, interleukin(IL)-6, and intercellular adhesion molecule-1 and endometrial mRNA levels of MMP-3, tumor necrosis factor(TNF)-α, and IL-8 were significantly higher during the menstrual phase when compared with luteal phase. During the menstrual phase of the cycle, both endometrial expression of TNF-α, IL-8, and MMP-3 mRNA levels and peritoneal expression of transforming growth factor-β, IL-6, and intercellular adhesion molecule-1 mRNA levels were significantly higher in women with endometriosis when compared with controls. Immunohistochemical staining confirmed the presence of TNF-αin peritoneum and endometrium in both women with endometriosis and controls. Conclusion(s): Increased endometrial and peritoneal cytokine mRNA expression during menstruation may contribute to a pelvic inflammatory microenvironment favoring the development of endometriosis. | Kyama C.M. Overbergh L. Debrock S. T.M. D'Hghe 党慧敏 | 2006 | 世界核心医学期刊文摘(妇产科学分册)2006，0，10： | 2 |
| 2 | A phase trial rosiglitazone in liposarcoma patients显示文摘 | Debrock G Vanhentenrijk V Sciot R | 2003 | Br J Cancer2003，89，8： | 1 |
| 3 | Potential involvement of the immune system in the development of endometriosis 显示文摘 | Cleophas M Kyama Sophie Debrock Jason M Mwenda | 2003 | Reprod Biol Endocrin2003，1，： | 1 |
| 4 | Tumour necrosis factor-alpha, interleukin-6 and interleukin-8 do not promote adhesion of human endometrial epithelial cells to mesothelial cells in a quantitative in vitro model显示文摘 | Debrock S De Strooper B Vander Perre S | 2006 | Hum Reprod2006，21，3： | 1 |
| 5 | The type of catheter has no impact on the pregnancy rate after intrauterine insemination: a randomized study 显示文摘 | Vermeylen AM D'Hooghe T Debrock S Meeuwis L Meuleman C Spiessens C | 2006 | Hum Reprod2006，16，： | 1 |
| 6 | Increased peritoneal and endometrial gene expression of biologically relevant cytokines and growth factors during the menstrual phase in women with endometriosis显示文摘 | KYAMA C M OVERBERGH L DEBROCK S | 2006 | Fertil Steril2006，85，6： | 1 |
| 7 | Endometriosis andsubfertility :is the relationship resolved? 显示文摘 | D Hooghe TM Debrock S Hill JA | 2003 | Semin Reprod Med2003，21，2： | 1 |
| 8 | Increased peritoneal and endometrial gene expression of biologically relevant cytokines and growth factors during the menstrual phase in women with endometriosis显示文摘 | Kyama CM Overbergh L Debrock S | 2006 | Fertil Steril2006，85，6： | 1 |
| 9 | A survey of current developments in surface tension devices for propellant acquisition显示文摘 | S C DeBrock etal | 1971 | spacecraft1971，18，2： | 1 |
| 10 | Endometriosis and subfertility:is the relationship resolved显示文摘 | D'Hooghe TM Debrock S Hill JA | 2003 | Semin Reprod Med2003，21，： | 1 |
| 11 | In-vitro adhesion of endometrimn to autologous peritoneal membranes : effect of the cycle phase and the stage of endometriosis 显示文摘 | Debrock S Vander Perre S Meuleman C | 2002 | Hum Reprod2002，17，： | 1 |
| 12 | Early embryo development in a sequential versus single medium:a randomized study 显示文摘 | Paternot G Debrock S D'Hooghe TM | 2010 | Reprod Biol Endocrinol2010，8，： | 1 |
| 13 | The effect of modified quarter laser-assisted zona thinning on the implantation rate per embryo in frozen/vitrified- thawed/warmed embryo transfer cycles : a prospective randomized controlled trial 显示文摘 | DEBROCK S | 2011 | Hum Reprod2011，26，8： | 1 |
| 14 | En- dometriosis and subfertility: is the relationship re- solved?显示文摘 | D'Hooghe TM Debrock S Hill JA | 2003 | Semin Reprod Med2003，21，2： | 1 |
| 15 | A pro- spective randomized study: day 2 versus day 5 embryo transfer显示文摘 | Van der Auwera I Debrock S Spiessens C | 2002 | Hum Reprod2002，17，6： | 1 |
| 16 | In-vitro adhesion of endometrium to autologous peritoneal membranes : effect of the cycle phase and the stage of endometriosis 显示文摘 | Debrock S Vander PS Meuleman C | 2002 | Hum Reprod2002，17，： | 1 |
| 17 | Future directions inendometriosis research显示文摘 | Df Hooghe TM Kyama C Debrock S | 2004 | Ann N Y Acad Sci2004，1034，： | 1 |
| 18 | Future directions in endometriosis research显示文摘 | D′Hooghe T M Kvama C Debrock S | 2004 | Ann NYAcad Sci2004，1034，： | 1 |
| 19 | Potential involvement of the immune system in the development of endometriosis显示文摘 | Kyama CM Debrock S Mwenda JM | 2003 | Reprod Biol Endocrinol2003，2，1： | 1 |
| 20 | Endometriosis and subfertility: is the relationship resolved显示文摘 | D' Hooghe TM Debrock S Hill JA | 2003 | Semin Re-prod Med2003，21，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员