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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Ureteral double-J wire stent effectiveness after endopyelotomy:an animal model study显示文摘 | Soria F Delgado MI Rioja L | 2010 | Urol Int2010，85，3： | 1 |
| 3 | Infectious complications of percutaneous central venous catheterization in pediatric patients: a Spanish multicenter study显示文摘 | Garcia M A Casado F J Delgado M A | 2007 | Intensive Care Med2007，33，3： | 1 |
| 4 | Cbnical presentation, management and outcomes inthe Acute Heart Failure Global Survey of Standard Treatment 显示文摘 | Follath F Yilmaz MB Delgado JF | 2011 | Intensive Care Med2011，374，： | 1 |
| 5 | Comparison of aortic root dimensions and geometries before and after transcatheter aortic valve implantation by 2-and 3-dimensional transesophageal echocardiography and multislice computed tomography显示文摘 | Ng AC Delgado V Van der Kley F | | 0，，01： | 1 |
| 6 | A communication model based on the 2-tuple fuzzy linguistic representation for a distributed intelligent agent system on Intemet显示文摘 | Delgado M Herrera F Herrera-Viedma E | 2002 | Soft Computing-A Fusion of Foundations Methodologies and Applications2002，6，5： | 1 |
| 7 | Effects of the river discharge management on the nursery function of the Guadalquivir river estuary (SW Spain) 显示文摘 | DELGADO C F BALDO F VILAS C | 2007 | Hydrobiologia2007，587，1： | 1 |
| 8 | Acquired haemophilia: review and meta-analysis focused on therapy and prognostic factors显示文摘 | DELGADO J JIMENEZ-YUSTE V HERNANDEZ-NAVARRO F | 2003 | Br J Haematol2003，121，1： | 1 |
| 9 | Lack of lymphoid cell apoptosis in the pathogenesis of tonsillar hypertrophy as compared to recurrent tonsillitis显示文摘 | LOPEZ-GONZALEZ M A DIAZ P DELGADO F | 1999 | Eur J Pediatr1999，158，： | 1 |
| 10 | The calpain system in three muscles of normal andcallipyge sheep显示文摘 | DELGADO E F | 2001 | Journal of Animal Science2001，79，： | 1 |
| 11 | Combining numerical and linguistic information in group decision making 显示文摘 | Delgado M Herrera F Herrera ViedmaE | 1998 | Information Sciences1998，107，2： | 1 |
| 12 | Plasma fruetosamine to evaluate metabolic control among women with gestational diabetes显示文摘 | Delgado M R Novik A V Cardemil M F | 2011 | Rev Med Chil2011，139，11： | 1 |
| 13 | , Scalable culture systems u- sing different cell lines for the production of Peste des Petits ruminantsvaccine 显示文摘 | Silva A C Delgado I Sousa M F | 2008 | Vaccine2008，26，26： | 1 |
| 14 | Chases in volatiles with the application of progressive freeze-concentration to Andes berry(Rubus glaucus Benth)显示文摘 | RAMOS F A DELGADO J L BAUTISTAE MORALES A L DUQUEC | 2005 | Journal of Food Engineering2005，，69： | 1 |
| 15 | Validation and comparison of advanced differential interferometry techniques: murcia metropolitan area case study显示文摘 | HERRERA G TOMAS R LOPEZ-SANCHEZ J M DELGADO J VICENTE F MULAS J COOKSLEY G SANCHEZ M DURO J ARNAUD A BLANCO P DUQUE S MALLORQUI J J DE la VEGA-PANIZO R MONSERRAT O | 2008 | ISPRS Journal of Photogrammetry and Remote Sensing2008，，： | 1 |
| 16 | Coevolutionary genetic fuzzy systems: A hierarchical collaborative approach 显示文摘 | Delgado M R Von Zuben F Gomide F | 2004 | Fuzzy Sets and Systems2004，141，1： | 1 |
| 17 | Parallel change in H2O2 and catalase during thermotolerance induced by salicylicacid or heat accllmalion in musturd seedings显示文摘 | Dat J F Lopez Delgado H | 1998 | Plant Physiol1998，116，： | 1 |
| 18 | Properties of myofibril-bound calpain activity in long- issimus muscle of callipyge and normal sheep显示文摘 | DELGADO E F | 2001 | Journal of Animal Science2001，79，： | 1 |
| 19 | Representation of context-dependant knowledge in ontologies: A model and an application 显示文摘 | Bobillo F Delgado M Gomez Romero J | 2008 | Expert Systems with Applications2008，35，4： | 1 |
| 20 | Acquired haemophilia:Review and meta-analysis Focused on Therapy and Prognostic Pactors显示文摘 | Jimenez-Yuste V Hernandez-Navarro F | 2003 | Br J Hematol2003，121，1： | 1 |
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