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	题名	作者	年代	出处	被引量
1	IDH1 and IDH2 mutations are prognostic but not predictive for outcome in anaplastic oligodendroglial tumors: a report of the European Organization for Research and Treat- ment of Cancer Brain Tumor Group显示文摘	van den Bent M J Dubbink HJ Marie Y Brandes AA Taphoorn MJ Wesseling P Frenay M Tijssen CC Lacombe D ldbaih A van Marion R Kros JM Dinjens WN Gorlia T. Sanson M.	2010	中国神经肿瘤杂志2010，8，1：	22
2	On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients显示文摘AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials.	Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB Engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder Dirk J de Jong	2005	World Journal of Gastroenterology2005，11，35：	4
3	Heart failure and incident late-life depression 显示文摘	Luijendijk HJ Tiemeier H van den Berg JF	2010	J Am Geriatr Soc2010，58，8：	1
4	Hyperhomocysteinemia as a risk factor for deep-vein thrombosis显示文摘	den Heijer M Koster T Blom HJ	1996	N Engl J Med1996，334，：	1
5	Hyperhomocysteinemia a risk factor for ischemic stroke in children显示文摘	van Beynum IM Smeitink JA den Heijer M te Poele Pothoff MT Blom HJ	1999	Circulation1999，99，16：	1
6	Adenosine triphosphate: established and potential clinical applications显示文摘	Agteresch HJ Dagnelie PC van den Berg JW	1999	Drugs1999，58，2：	1
7	Adenosine triphosphate: established and potential clinical applications显示文摘	Dagnelie PC van den Berg JW	1999	Drags1999，58，2：	1
8	The diagnosticvalue of the combinationof patient characteristics,history,and clinicalshouldertests for the diagnosisof rotatorcufftear显示文摘	van Kampen DA van den Berg T van der Woude HJ	2014	Journal of Orthopaedic Surgery and Research2014，9，：	1
9	Oral keratinocytes cultured on dermal matrices form a mucosa-like tissue显示文摘	van Rheden RE Von den HJ	2002	Biomaterials2002，23，17：	1
10	Depression and cognitive impairment in Parkinson’s disease:a role for inflammation and immunomodulation显示文摘	Pessoa Rocha NL Reis HJ van den Berghe P	2014	Neuroimmunomodulation2014，21，23：	1
11	Hyperhomocysteinemia as a risk factor for deep-vein thrombosis显示文摘	den Heijer M Koster T Blom HJ	1996	N Engl J Med1996，334，12：	1
12	Neural tube defects and folate: case for from closed显示文摘	Blom HJ Shaw GM den Heijer M	2006	Nat Rev Neurosci2006，7，9：	1
13	MGMT promoter methylation is prognostic but not predictive for outcome to adjuvant PCV chemotherapy in anaplastic oligodendroglial tumors: a report from EORTC Brain Tumor Group Study 26951 显示文摘	van den Bent MJ Dubbink HJ Sanson M	2009	J Clin Oncol2009，27，35：	1
14	Genetic and in vivo determinants of glucocorticoid sensitivity in relation to clinical outcome of childhood nephrotic syndrome显示文摘	TEENINGA N KIST-VAN HJ VAN DEN AKKER EL	2014	Kidney Int2014，85，6：	1
15	Hyperhomocysteinemia as a risk factor for deep vein thrombosis显示文摘	Den Heijer M Koster T Blom HJ	1996	N Engl J Med1996，334，：	1
16	Adenosine triphosphate:established and potential clinical applications显示文摘	Agteresch HJ Dagnelie PC van den Berg JW	1999	Drugs1999，58，2：	1
17	Hyperhomocysteinemia as a risk factor for deep-vein thrombosis显示文摘	Den Heijer M Koster T Blom HJ	1996	N EnglJMed1996，334，：	1
18	Value of gene polymorphisms as markers of 5-FU therapy response in stage III colon carcinoma: A pilot study 显示文摘	Farifia-Sarasqueta A van Lijnschoten G Rutten HJ van den Brule AJ	2010	Cancer Chemother Pharmacol2010，，：	1
19	Interaction of biffdobacterial lipoteichoic acid with human intestinal epithelial cells 显示文摘	Op den Camp HJ Oosterhof A Veerkamp JH	1985	Infect Immun1985，47，1：	1
20	Effect of peroneal electrical stimulation versus an ankle-foot orthosis on obstacle avoidance ability in people with stroke-related foot drop显示文摘	van Swigchem R van Duijnhoven HJ den Boer J	2012	Phys Ther2012，92，3：	1

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